Access the full text.
Sign up today, get DeepDyve free for 14 days.
E Alvarez, IC Northwood, FA Gonzalez, DA Latour, A Seth, C Abate, T Curran, RJ Davis (1991)
Pro–Leu–Ser/Thr–Pro is a consensus primary sequence for substrate protein phosphorylationJ Biol Chem, 266
Qiuling Wang, C. Fiol, A. Depaoli-Roach, P. Roach (1994)
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.The Journal of biological chemistry, 269 20
A. Cuenda, J. Rouse, Y. Doza, R. Meier, Philip Cohen, T. Gallagher, P. Young, John Lee (1995)
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1FEBS Letters, 364
Athanasios Papavassiliou, Mathias Treier, Dirk Bohmann (1995)
Intramolecular signal transduction in c‐Jun.The EMBO Journal, 14
V. Stambolic, L. Ruel, J. Woodgett (1996)
Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cellsCurrent Biology, 6
Sy Chou, V. Baichwal, Jr Ferrell (1992)
Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.Molecular biology of the cell, 3 10
Y. Woods, Philip Cohen, W. Becker, R. Jakes, M. Goedert, Xuemin Wang, C. Proud (2001)
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.The Biochemical journal, 355 Pt 3
Y. Maki, T. Bos, C. Davis, M. Starbuck, P. Vogt (1987)
Avian sarcoma virus 17 carries the jun oncogene.Proceedings of the National Academy of Sciences of the United States of America, 84 9
S. Davies, Helen Reddy, M. Caivano, P. Cohen (2000)
Specificity and mechanism of action of some commonly used protein kinase inhibitorsBiochemical Journal, 351
M. Hibi, A. Lin, T. Smeal, A. Minden, M. Karin (1993)
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.Genes & development, 7 11
B. Pulverer, J. Kyriakis, J. Avruch, E. Nikolakaki, J. Woodgett (1991)
Phosphorylation of c-jun mediated by MAP kinasesNature, 353
P. Klein, D. Melton (1996)
A molecular mechanism for the effect of lithium on development.Proceedings of the National Academy of Sciences of the United States of America, 93 16
P. Angel, M. Karin (1991)
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.Biochimica et biophysica acta, 1072 2-3
J. Bain, H. Mclauchlan, M. Elliott, P. Cohen (2003)
The specificities of protein kinase inhibitors: an update.The Biochemical journal, 371 Pt 1
Y. Lee, J. Giraud, R. Davis, M. White (2003)
c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade*The Journal of Biological Chemistry, 278
E. Alvarez, I. Northwood, F. Gonzalez, Debra Latour, A. Seth, C. Abate, T. Curran, R. Davis (1991)
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.The Journal of biological chemistry, 266 23
E. Black, A. Catling, James Woodgett, A. Kilbey, David Gillespie (1994)
Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation.Oncogene, 9 8
R. Davis (2000)
Signal Transduction by the JNK Group of MAP KinasesCell, 103
C. Picton, J. Woodgett, B. Hemmings, P. Cohen (1982)
Multisite phosphorylation of glycogen synthase from rabbit skeletal muscleFEBS Letters, 150
T. Smeal, B. Binétruy, D. Mercola, M. Birrer, M. Karin (1991)
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73Nature, 354
M. Bradford (1976)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Analytical biochemistry, 72
S. Frame, P. Cohen (2001)
GSK3 takes centre stage more than 20 years after its discovery.The Biochemical journal, 359 Pt 1
C Picton, JR Woodgett, B Hemmings, P Cohen (1982)
Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Phosphorylation of site 5 by glycogen synthase kinase‐5 (casein kinase‐II) is a prerequisite for phosphorylation of site 3 by glycogen synthase kinase‐3FEBS Lett, 150
J. Sebolt-Leopold, D. Dudley, R. Herrera, K. Becelaere, A. Wiland, Richard Gowan, H. Tecle, S. Barrett, A. Bridges, S. Przybranowski, W. Leopold, A. Saltiel (1999)
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoNature Medicine, 5
J. Hilpert, H. Vorum, R. Burmeister, R. Spoelgen, I. Grishkovskaya, R. Misselwitz, A. Nykjaer, T. Willnow (2001)
Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.The Biochemical journal, 360 Pt 3
E. Shaulian, M. Karin (2001)
AP-1 in cell proliferation and survivalOncogene, 20
K. Hughes, E. Nikolakaki, S. Plyte, N. Totty, J. Woodgett (1993)
Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation.The EMBO Journal, 12
C. Tournier, P. Hess, Derek Yang, Jie Xu, Tod Turner, A. Nimnual, D. Bar-Sagi, S. Jones, R. Flavell, R. Davis (2000)
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.Science, 288 5467
M. Leost, C. Schultz, A. Link, Yong-zhong Wu, J. Biernat, E. Mandelkow, J. Bibb, G. Snyder, P. Greengard, D. Zaharevitz, R. Gussio, A. Senderowicz, E. Sausville, C. Kunick, L. Meijer (2000)
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.European journal of biochemistry, 267 19
W. Boyle, T. Smeal, L. Defize, P. Angel, J. Woodgett, M. Karin, T. Hunter (1991)
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activityCell, 64
A. Lin, J. Frost, T. Deng, T. Smeal, N. Al-Alawi, U. Kikkawa, T. Hunter, D. Brenner, M. Karin (1992)
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activityCell, 70
We have used phospho‐specific antibodies to re‐examine the multisite phosphorylation of c‐Jun in murine RAW macrophages and embryonic fibroblasts. Our results indicate that JNK isoforms are required and sufficient for the phosphorylation of Thr91 and Thr93, as well as the phosphorylation of Ser63 and Ser73, in response to LPS or anisomycin in macrophages and TNFα or anisomycin in fibroblasts. However, the phorbol ester (TPA) and EGF‐induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild‐type mice and by ERK1/ERK2 alone in fibroblasts from JNK‐deficient mice. The phosphorylation of Thr239 is catalysed by GSK3 and the phosphorylation of Ser243 by an as yet unidentified protein kinase. The inhibition of GSK3 is not required for the dephosphorylation of Thr239 in response to LPS, and nor is the phosphorylation of Thr91 and Thr93 required for the TPA‐ or EGF‐induced dephosphorylation of Thr239 in fibroblasts. The agonist‐induced dephosphorylation of Thr239 may involve a conformational change that exposes Thr239 to dephosphorylation and/or the activation of a Thr239 phosphatase.
The EMBO Journal – Wiley
Published: Jan 1, 2003
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.