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The Megaloblastic Anemias

The Megaloblastic Anemias By D. L. MOLLI N M D , . . Department of Hemarvlogy, Postgraduate Medical School of London, London, England Megaloblastic anemia most frequently occurs in patients who are unable to absorb normal amounts of B12 or folic acid but it is also found in a variety of other conditions in which the pathogenesis of the anemia is more obscure. For example, although MA may occur in patients whose diet is deficient in animal protein, the inadequate diet is rarely the sole precipitating factor. Inadequate dietary intake is usually associated with pregnancy (1) , chronic increased hemolysis (2, 3) , chronic iron deficiency anemia (4) , latent intestinal malabsorption (5, 6), scurvy (7, 8), with liver damage caused by cirrhosis (9,10), or with kwashiorkor (11) . The importance of these associated conditions is emphasized by the fact that MA may occur in some of them even in the absence of dietary deficiency or of intestinal malabsorption. Megalo blastic anemia of pregnancy in the temperate zone, for example, frequently occurs in patients who maintain a good diet and whose intestinal function is normal (1, 12). A similar state is described in patients with MA associated with hemolytic anemia (3, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

The Megaloblastic Anemias

Mollin, D L
Annual Review of Medicine , Volume 11 (1) – Feb 1, 1960
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Publisher
Annual Reviews
Copyright
Copyright 1960 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.11.020160.002001
pmid
14423429
Publisher site
See Article on Publisher Site

Abstract

By D. L. MOLLI N M D , . . Department of Hemarvlogy, Postgraduate Medical School of London, London, England Megaloblastic anemia most frequently occurs in patients who are unable to absorb normal amounts of B12 or folic acid but it is also found in a variety of other conditions in which the pathogenesis of the anemia is more obscure. For example, although MA may occur in patients whose diet is deficient in animal protein, the inadequate diet is rarely the sole precipitating factor. Inadequate dietary intake is usually associated with pregnancy (1) , chronic increased hemolysis (2, 3) , chronic iron deficiency anemia (4) , latent intestinal malabsorption (5, 6), scurvy (7, 8), with liver damage caused by cirrhosis (9,10), or with kwashiorkor (11) . The importance of these associated conditions is emphasized by the fact that MA may occur in some of them even in the absence of dietary deficiency or of intestinal malabsorption. Megalo blastic anemia of pregnancy in the temperate zone, for example, frequently occurs in patients who maintain a good diet and whose intestinal function is normal (1, 12). A similar state is described in patients with MA associated with hemolytic anemia (3,

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1960

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