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Cardiovascular change and hypothalamic norepinephrine release in response to environmental stress

Cardiovascular change and hypothalamic norepinephrine release in response to environmental stress Nakata, Tetsuo, Natalie Alexander. William Berard, Ella Kogosov, and Cardiovascularchangeand hypothalamic norepinephrinerelease response environmental stress. in to Am. dependent manner. Tachycardia occurred at 150 but not 60 cycles/min. Ten minutes after 60 cycles/min and 15 min after 150cycles/min, NE efflux in PH wasstill increased,whereasin PVN it returned to control as had arterial pressureand heart rate. Ether vapor elicited a transient CV responsebut a continuing efflux of NE in PH and PVN. Urethan anesthesia raised baselinevalues of dialysate NE in PH and PVN but significantly attenuated cardiovascularand dialysate NE responses to shaker stress.We conclude that acute environmental stresssimultaneously elicits CV responses and the efflux of NE from PVN and PH but, during or after stress,CV values may return to control levels while NE efflux remains elevated in PVN and/or PH. in vivo microdialysis; paraventricular hypothalamic nucleus; posterior hypothalamic nucleus; norepinephrine; blood pressure;plasmacatecholaminesand corticosterone; urethan THE MATERIALS AND METHODS CLASSICAL DEFENSE REACTION elicited by acute stress includes elevation of arterial pressure and redistribution of blood. These changes can be reproduced by stimulation of specific areas of the hypothalamus, suggesting the latter may be a major site of central activation during stress (32). Norepinephrine (NE) turnover (7,27) and synthesis (6) increase http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Cardiovascular change and hypothalamic norepinephrine release in response to environmental stress

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Publisher
The American Physiological Society
Copyright
Copyright © 1993 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
See Article on Publisher Site

Abstract

Nakata, Tetsuo, Natalie Alexander. William Berard, Ella Kogosov, and Cardiovascularchangeand hypothalamic norepinephrinerelease response environmental stress. in to Am. dependent manner. Tachycardia occurred at 150 but not 60 cycles/min. Ten minutes after 60 cycles/min and 15 min after 150cycles/min, NE efflux in PH wasstill increased,whereasin PVN it returned to control as had arterial pressureand heart rate. Ether vapor elicited a transient CV responsebut a continuing efflux of NE in PH and PVN. Urethan anesthesia raised baselinevalues of dialysate NE in PH and PVN but significantly attenuated cardiovascularand dialysate NE responses to shaker stress.We conclude that acute environmental stresssimultaneously elicits CV responses and the efflux of NE from PVN and PH but, during or after stress,CV values may return to control levels while NE efflux remains elevated in PVN and/or PH. in vivo microdialysis; paraventricular hypothalamic nucleus; posterior hypothalamic nucleus; norepinephrine; blood pressure;plasmacatecholaminesand corticosterone; urethan THE MATERIALS AND METHODS CLASSICAL DEFENSE REACTION elicited by acute stress includes elevation of arterial pressure and redistribution of blood. These changes can be reproduced by stimulation of specific areas of the hypothalamus, suggesting the latter may be a major site of central activation during stress (32). Norepinephrine (NE) turnover (7,27) and synthesis (6) increase

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Apr 1, 1993

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