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S. Huveneers, E. Danen (2009)
Adhesion signaling – crosstalk between integrins, Src and RhoJournal of Cell Science, 122
Chi-hung Lin, P. Forscher (1995)
Growth cone advance is inversely proportional to retrograde F-actin flowNeuron, 14
J. Iwasa, R. Mullins (2007)
Spatial and Temporal Relationships between Actin-Filament Nucleation, Capping, and DisassemblyCurrent Biology, 17
C. Mierke, D. Rösel, B. Fabry, J. Brábek (2008)
Contractile forces in tumor cell migration.European journal of cell biology, 87 8-9
Wei-hui Guo, Yu-li Wang (2007)
Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals.Molecular biology of the cell, 18 11
D. Calderwood, R. Zent, Richard Grant, D. Rees, R. Hynes, M. Ginsberg (1999)
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*The Journal of Biological Chemistry, 274
P. Vallotton, S. Gupton, C. Waterman-Storer, G. Danuser (2004)
Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy.Proceedings of the National Academy of Sciences of the United States of America, 101 26
R. Pelham, Yu-li Wang (1997)
Cell locomotion and focal adhesions are regulated by substrate flexibility.Proceedings of the National Academy of Sciences of the United States of America, 94 25
T. Amano, T. Amano, Kazuyo Tanabe, Tomonori Eto, S. Narumiya, Kensaku Mizuno, Kensaku Mizuno (2001)
LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505.The Biochemical journal, 354 Pt 1
J. Heath, B. Holifield (1993)
On the mechanisms of cortical actin flow and its role in cytoskeletal organisation of fibroblasts.Symposia of the Society for Experimental Biology, 47
A. Bershadsky, N. Balaban, B. Geiger (2003)
Adhesion-dependent cell mechanosensitivity.Annual review of cell and developmental biology, 19
R. Zaidel-Bar, C. Ballestrem, Z. Kam, B. Geiger (2003)
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cellsJournal of Cell Science, 116
Anjana Nayal, D. Webb, C. Brown, E. Schaefer, M. Vicente-Manzanares, A. Horwitz (2006)
Paxillin phosphorylation at Ser273 localizes a GIT1–PIX–PAK complex and regulates adhesion and protrusion dynamicsThe Journal of Cell Biology, 173
E. Sander, J. Klooster, Sanne Delft, R. Kammen, John Collard (1999)
Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory BehaviorJournal of Cell Biology, 147
J. Côté, K. Vuori (2002)
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activityJournal of Cell Science, 115
S. Gupton, C. Waterman-Storer (2006)
Spatiotemporal Feedback between Actomyosin and Focal-Adhesion Systems Optimizes Rapid Cell MigrationCell, 125
A. Rio, R. Perez-Jimenez, Ruchuan Liu, Pere Roca-Cusachs, Julio Fernandez, M. Sheetz (2009)
Stretching Single Talin Rod Molecules Activates Vinculin BindingScience, 323
T. Petrie, J. Capadona, C. Reyes, Andrés García (2006)
Integrin specificity and enhanced cellular activities associated with surfaces presenting a recombinant fibronectin fragment compared to RGD supports.Biomaterials, 27 31
E. Brugnera, L. Haney, Cynthia Grimsley, Mingjian Lu, S. Walk, A. Tosello-Trampont, I. Macara, H. Madhani, G. Fink, K. Ravichandran (2002)
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complexNature Cell Biology, 4
S. Tadokoro, S. Shattil, K. Eto, Vera Tai, R. Liddington, J. Pereda, M. Ginsberg, D. Calderwood (2003)
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin ActivationScience, 302
A. Caño-Delgado, Ji-Young Lee, T. Demura (2010)
Regulatory mechanisms for specification and patterning of plant vascular tissues.Annual review of cell and developmental biology, 26
E. Zamir, B. Katz, S. Aota, K. Yamada, B. Geiger, Z. Kam (1999)
Molecular diversity of cell-matrix adhesions.Journal of cell science, 112 ( Pt 11)
B. Serrels, A. Serrels, V. Brunton, M. Holt, G. Mclean, C. Gray, G. Jones, M. Frame (2007)
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complexNature Cell Biology, 9
M. Bailly, F. Macaluso, M. Cammer, Amanda Chan, J. Segall, J. Condeelis (1999)
Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor StimulationThe Journal of Cell Biology, 145
Guoying Jiang, G. Giannone, D. Critchley, E. Fukumoto, M. Sheetz (2003)
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talinNature, 424
M. Symons, T. Mitchison (1991)
Control of actin polymerization in live and permeabilized fibroblastsThe Journal of Cell Biology, 114
R. Worthylake, K. Burridge (2003)
RhoA and ROCK Promote Migration by Limiting Membrane Protrusions*The Journal of Biological Chemistry, 278
Takushi Miyoshi, T. Tsuji, C. Higashida, Maud Hertzog, A. Fujita, S. Narumiya, G. Scita, N. Watanabe (2006)
Actin turnover–dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severingThe Journal of Cell Biology, 175
C. Lo, D. Buxton, G. Chua, M. Dembo, R. Adelstein, Yu-li Wang (2003)
Nonmuscle myosin IIb is involved in the guidance of fibroblast migration.Molecular biology of the cell, 15 3
L. Sanders, F. Matsumura, G. Bokoch, P. Lanerolle (1999)
Inhibition of myosin light chain kinase by p21-activated kinase.Science, 283 5410
Ho-Sup Lee, R. Bellin, D. Walker, B. Patel, Pam Powers, Hongjun Liu, Begoña García-Álvarez, J. Pereda, R. Liddington, N. Volkmann, D. Hanein, D. Critchley, R. Robson (2004)
Characterization of an actin-binding site within the talin FERM domain.Journal of molecular biology, 343 3
Colin Johnson, Hsin-Yao Tang, Christine Carag, D. Speicher, D. Discher (2007)
Forced Unfolding of Proteins Within CellsScience, 317
A. Locascio, M. Nieto (2001)
Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration.Current opinion in genetics & development, 11 4
O. Krylyshkina, I. Kaverina, W. Kranewitter, W. Steffen, M. Alonso, R. Cross, J. Small (2002)
Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1The Journal of Cell Biology, 156
I. Ichetovkin, Wayne Grant, J. Condeelis (2002)
Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 ComplexCurrent Biology, 12
Daniel Suter, P. Forscher (2000)
Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance.Journal of neurobiology, 44 2
E. Zamir, B. Geiger (2001)
Molecular complexity and dynamics of cell-matrix adhesions.Journal of cell science, 114 Pt 20
T. Svitkina, A. Verkhovsky, Kyle McQuade, G. Borisy (1997)
Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body TranslocationThe Journal of Cell Biology, 139
J. Sanger, J. Sanger, Jockusch Bm (1983)
Differences in the stress fibers between fibroblasts and epithelial cellsThe Journal of Cell Biology, 96
C. Selhuber‐Unkel, M. López-García, H. Kessler, J. Spatz (2008)
Cooperativity in adhesion cluster formation during initial cell adhesion.Biophysical journal, 95 11
Ellen Ezratty, M. Partridge, G. Gundersen (2005)
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinaseNature Cell Biology, 7
D. Critchley (2004)
Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.Biochemical Society transactions, 32 Pt 5
Sanjay Kumar, I. Maxwell, A. Heisterkamp, Tom Polte, T. Lele, M. Salanga, E. Mazur, D. Ingber (2006)
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.Biophysical journal, 90 10
Sui Huang, D. Ingber (2005)
Cell tension, matrix mechanics, and cancer development.Cancer cell, 8 3
T. Anderson, Andrew Vaughan, L. Cramer (2008)
Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts.Molecular biology of the cell, 19 11
Vera Desmarais, I. Ichetovkin, J. Condeelis, S. Hitchcock-DeGregori (2002)
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edgeJournal of Cell Science, 115
J. Sinnett-Smith, J. Lunn, Daniela Leopoldt, E. Rozengurt (2001)
Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).Experimental cell research, 266 2
A. Harris (1973)
Cell surface movements related to cell locomotion.Ciba Foundation symposium, 14
Lynda Peterson, Z. Rajfur, A. Maddox, C. Freel, Yun Chen, M. Edlund, C. Otey, K. Burridge (2004)
Simultaneous stretching and contraction of stress fibers in vivo.Molecular biology of the cell, 15 7
S. Gupton, K. Anderson, T. Kole, R. Fischer, A. Ponti, S. Hitchcock-DeGregori, G. Danuser, V. Fowler, D. Wirtz, D. Hanein, C. Waterman-Storer (2005)
Cell migration without a lamellipodiumThe Journal of Cell Biology, 168
J. Colombelli, A. Besser, H. Kress, E. Reynaud, P. Girard, E. Caussinus, U. Haselmann, J. Small, U. Schwarz, E. Stelzer (2009)
Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localizationJournal of Cell Science, 122
D. Calderwood, M. Ginsberg (2003)
Talin forges the links between integrins and actinNature Cell Biology, 5
Ning Wang, I. Tolic-Nørrelykke, Jianxin Chen, S. Mijailovich, J. Butler, J. Fredberg, D. Stamenović (2002)
Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells.American journal of physiology. Cell physiology, 282 3
G. Wichert, B. Haimovich, G. Feng, M. Sheetz (2003)
Force‐dependent integrin–cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2The EMBO Journal, 22
A. Verkhovsky, T. Svitkina, G. Borisy (1995)
Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundlesThe Journal of Cell Biology, 131
A. Alexandrova, Katya Arnold, S. Schaub, J. Vasiliev, J. Meister, A. Bershadsky, A. Verkhovsky (2008)
Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow FlowPLoS ONE, 3
A. Ponti, M. Machacek, S. Gupton, C. Waterman-Storer, G. Danuser (2004)
Two Distinct Actin Networks Drive the Protrusion of Migrating CellsScience, 305
M. Vicente-Manzanares, Colin Choi, A. Horwitz (2009)
Integrins in cell migration – the actin connectionJournal of Cell Science, 122
Pirta Hotulainen, P. Lappalainen (2006)
Stress fibers are generated by two distinct actin assembly mechanisms in motile cellsThe Journal of Cell Biology, 173
B. Wehrle-Haller, B. Imhof (2003)
Actin, microtubules and focal adhesion dynamics during cell migration.The international journal of biochemistry & cell biology, 35 1
M. Schober, Srikala Raghavan, M. Nikolova, Lisa Polak, H. Pasolli, Hilary Beggs, L. Reichardt, E. Fuchs (2007)
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamicsThe Journal of Cell Biology, 176
C. Brown, Benedict Hébert, D. Kolin, Jessica Zareno, Leanna Whitmore, A. Horwitz, P. Wiseman (2006)
Probing the integrin-actin linkage using high-resolution protein velocity mappingJournal of Cell Science, 119
S. Palecek, J. Loftus, M. Ginsberg, D. Lauffenburger, A. Horwitz (1997)
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessNature, 385
R. Zaidel-Bar, S. Itzkovitz, Avi Ma’ayan, R. Iyengar, B. Geiger (2007)
Functional atlas of the integrin adhesomeNature Cell Biology, 9
P. Rajagopalan, W. Marganski, X. Brown, J. Wong (2004)
Direct comparison of the spread area, contractility, and migration of balb/c 3T3 fibroblasts adhered to fibronectin- and RGD-modified substrata.Biophysical journal, 87 4
W. Arthur, K. Burridge (2001)
RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity.Molecular biology of the cell, 12 9
Christina Laukaitis, D. Webb, K. Donais, A. Horwitz (2001)
Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating CellsThe Journal of Cell Biology, 153
Carlos Jurado, J. Haserick, Juliet Lee (2004)
Slipping or gripping? Fluorescent speckle microscopy in fish keratocytes reveals two different mechanisms for generating a retrograde flow of actin.Molecular biology of the cell, 16 2
P. Wiseman, C. Brown, D. Webb, Benedict Hébert, Natalie Johnson, J. Squier, Mark Ellisman, A. Horwitz (2004)
Spatial mapping of integrin interactions and dynamics during cell migration by Image Correlation MicroscopyJournal of Cell Science, 117
S. Kaufmann, T. Piekenbrock, W. Goldmann, M. Bärmann, G. Isenberg (1991)
Talin binds to actin and promotes filament nucleationFEBS Letters, 284
P. Forscher, Stephen Smith (1988)
Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth coneThe Journal of Cell Biology, 107
C. Nobes, P. Hawkins, L. Stephens, A. Hall (1995)
Activation of the small GTP-binding proteins rho and rac by growth factor receptors.Journal of cell science, 108 ( Pt 1)
Akira Katsumi, J. Milanini, W. Kiosses, M. Pozo, R. Kaunas, S. Chien, K. Hahn, M. Schwartz (2002)
Effects of cell tension on the small GTPase RacThe Journal of Cell Biology, 158
K. Michael, D. Dumbauld, Kellie Burns, S. Hanks, Andrés García (2009)
Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.Molecular biology of the cell, 20 9
J. Tan, J. Tien, Dana Pirone, D. Gray, K. Bhadriraju, Christopher Chen (2003)
Cells lying on a bed of microneedles: An approach to isolate mechanical forceProceedings of the National Academy of Sciences of the United States of America, 100
Christianne Gaudet, W. Marganski, Sooyoung Kim, C. Brown, Vaibhavi Gunderia, M. Dembo, J. Wong (2003)
Influence of type I collagen surface density on fibroblast spreading, motility, and contractility.Biophysical journal, 85 5
F. Kong, Andrés García, A. Mould, M. Humphries, C. Zhu (2009)
Demonstration of catch bonds between an integrin and its ligandThe Journal of Cell Biology, 185
D. Riveline, E. Zamir, N. Balaban, U. Schwarz, T. Ishizaki, S. Narumiya, Z. Kam, B. Geiger, A. Bershadsky (2001)
Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent MechanismJournal of Cell Biology, 153
C. Pritchard, Louise Hayes, L. Wojnowski, A. Zimmer, R. Marais, J. Norman (2004)
B-Raf Acts via the ROCKII/LIMK/Cofilin Pathway To Maintain Actin Stress Fibers in FibroblastsMolecular and Cellular Biology, 24
K. Hu, Lin Ji, Kathryn Applegate, G. Danuser, C. Waterman-Storer (2007)
Differential Transmission of Actin Motion Within Focal AdhesionsScience, 315
K. DeMali, C. Barlow, K. Burridge (2002)
Recruitment of the Arp2/3 complex to vinculinThe Journal of Cell Biology, 159
J. Faix, K. Rottner (2006)
The making of filopodia.Current opinion in cell biology, 18 1
M. Dembo, Yu-li Wang (1999)
Stresses at the cell-to-substrate interface during locomotion of fibroblasts.Biophysical journal, 76 4
Matthias Machacek, Gaudenz Danuser (2006)
Morphodynamic profiling of protrusion phenotypes.Biophysical journal, 90 4
Yunfei Cai, N. Biais, G. Giannone, M. Tanase, Guoying Jiang, J. Hofman, C. Wiggins, P. Silberzan, A. Buguin, B. Ladoux, M. Sheetz (2006)
Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow.Biophysical journal, 91 10
G. Wichert, Guoying Jiang, A. Kostić, K. Vos, J. Sap, M. Sheetz (2003)
RPTP-α acts as a transducer of mechanical force on αv/β3-integrin–cytoskeleton linkagesThe Journal of Cell Biology, 161
I. Kaverina, O. Krylyshkina, J. Small, V. Small (1999)
Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and DissociationThe Journal of Cell Biology, 146
A. Gilmore, K. Burridge (1996)
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphateNature, 381
A. Mogilner, G. Oster (1996)
The physics of lamellipodial protrusionEuropean Biophysics Journal, 25
J. Goffin, P. Pittet, G. Csucs, J. Lussi, J. Meister, B. Hinz (2006)
Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibersThe Journal of Cell Biology, 172
K. Burton, J. Park, D. Taylor (1999)
Keratocytes generate traction forces in two phases.Molecular biology of the cell, 10 11
G. Giannone, Benjamin Dubin-Thaler, O. Rossier, Yunfei Cai, O. Chaga, Guoying Jiang, William Beaver, H. Döbereiner, Y. Freund, G. Borisy, M. Sheetz (2007)
Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site FormationCell, 128
J. Couchman, D. Rees (1979)
The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.Journal of cell science, 39
D. Lauffenburger, A. Horwitz (1996)
Cell Migration: A Physically Integrated Molecular ProcessCell, 84
L. Cramer, Margaret Siebert, T. Mitchison (1997)
Identification of Novel Graded Polarity Actin Filament Bundles in Locomoting Heart Fibroblasts: Implications for the Generation of Motile ForceThe Journal of Cell Biology, 136
Shigeo Okabe, Nobutaka Hirokawa (1991)
Actin dynamics in growth cones, 11
Paola Betancur, M. Bronner‐Fraser, T. Sauka-Spengler (2010)
Assembling neural crest regulatory circuits into a gene regulatory network.Annual review of cell and developmental biology, 26
Michael Brown, L. Cary, J. Jamieson, Jonathan Cooper, C. Turner (2005)
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Molecular biology of the cell, 16 9
Juliet Lee, M. Leonard, Tun Oliver, A. Ishihara, K. Jacobson (1994)
Traction forces generated by locomoting keratocytesThe Journal of Cell Biology, 127
K. Beningo, Kozue Hamao, M. Dembo, Yu-li Wang, H. Hosoya (2006)
Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase.Archives of biochemistry and biophysics, 456 2
Y. Shiu, Song Li, W. Marganski, S. Usami, M. Schwartz, Yu-li Wang, M. Dembo, S. Chien (2004)
Rho mediates the shear-enhancement of endothelial cell migration and traction force generation.Biophysical journal, 86 4
Clarence Chan, D. Odde (2008)
Traction Dynamics of Filopodia on Compliant SubstratesScience, 322
Jianghai Zhu, B. Luo, T. Xiao, Cheng-Zhong Zhang, N. Nishida, T. Springer (2008)
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.Molecular cell, 32 6
R. Zaidel-Bar, R. Milo, Z. Kam, B. Geiger (2006)
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesionsJournal of Cell Science, 120
Tom Shemesh, B. Geiger, A. Bershadsky, M. Kozlov (2005)
Focal adhesions as mechanosensors: a physical mechanism.Proceedings of the National Academy of Sciences of the United States of America, 102 35
M. Chrzanowska-Wodnicka, K. Burridge (1996)
Rho-stimulated contractility drives the formation of stress fibers and focal adhesionsThe Journal of Cell Biology, 133
T. Yeung, Penelope Georges, L. Flanagan, B. Marg, Miguelina Ortiz, M. Funaki, Nastaran Zahir, W. Ming, V. Weaver, P. Janmey (2005)
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.Cell motility and the cytoskeleton, 60 1
G. Giannone, Guoying Jiang, Deborah Sutton, D. Critchley, M. Sheetz (2003)
Talin1 is critical for force-dependent reinforcement of initial integrin–cytoskeleton bonds but not tyrosine kinase activationThe Journal of Cell Biology, 163
A. Verkhovsky, Tatyana Svitkina, G. Borisy (1999)
Network contraction model for cell translocation and retrograde flow.Biochemical Society symposium, 65
M. Lombardi, D. Knecht, M. Dembo, Juliet Lee (2007)
Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movementJournal of Cell Science, 120
I. Schneider, Cristen Hays, Clare Waterman (2009)
Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion.Molecular biology of the cell, 20 13
C. Lo, Hong Wang, M. Dembo, Yu-li Wang (2000)
Cell movement is guided by the rigidity of the substrate.Biophysical journal, 79 1
John Henson, John Henson, Tatyana Svitkina, Andrew Burns, Heather Hughes, Kenneth MacPartland, Ronniel Nazarian, Ronniel Nazarian, G. Borisy (1999)
Two components of actin-based retrograde flow in sea urchin coelomocytes.Molecular biology of the cell, 10 12
C. Galbraith, Kenneth Yamada, J. Galbraith (2007)
Polymerizing Actin Fibers Position Integrins Primed to Probe for Adhesion SitesScience, 315
Alexandra Goldyn, B. Rioja, J. Spatz, C. Ballestrem, R. Kemkemer (2009)
Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion slidingJournal of Cell Science, 122
N. Balaban, U. Schwarz, D. Riveline, P. Goichberg, Gil Tzur, I. Sabanay, D. Mahalu, S. Safran, A. Bershadsky, L. Addadi, B. Geiger (2001)
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substratesNature Cell Biology, 3
R. Zaidel-Bar, Miriam Cohen, L. Addadi, B. Geiger (2004)
Hierarchical assembly of cell-matrix adhesion complexes.Biochemical Society transactions, 32 Pt3
C. Galbraith, Kenneth Yamada, M. Sheetz (2002)
The relationship between force and focal complex developmentThe Journal of Cell Biology, 159
M. Holinstat, N. Knezevic, M. Broman, A. Samarel, A. Malik, D. Mehta (2006)
Suppression of RhoA Activity by Focal Adhesion Kinase-induced Activation of p190RhoGAPJournal of Biological Chemistry, 281
D. Webb, K. Donais, Leanna Whitmore, Sheila Thomas, C. Turner, J. Parsons, A. Horwitz (2004)
FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassemblyNature Cell Biology, 6
A. Mallavarapu, T. Mitchison (1999)
Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and RetractionThe Journal of Cell Biology, 146
Y. Wang (1985)
Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmillingThe Journal of Cell Biology, 101
M. Abercrombie, J. Heaysman, S. Pegrum (1971)
The locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella.Experimental cell research, 67 2
S. Gupton, Kathryn Eisenmann, A. Alberts, C. Waterman-Storer (2007)
mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migrationJournal of Cell Science, 120
T. Pollard, G. Borisy (2003)
Cellular Motility Driven by Assembly and Disassembly of Actin FilamentsCell, 113
Albert Keung, Sanjay Kumar, D. Schaffer (2010)
Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues.Annual review of cell and developmental biology, 26
T. Volberg, L. Romer, E. Zamir, B. Geiger (2001)
pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions.Journal of cell science, 114 Pt 12
R. Johnston, C. Desplan (2010)
Stochastic mechanisms of cell fate specification that yield random or robust outcomes.Annual review of cell and developmental biology, 26
C. Nobes, A. Hall (1995)
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaCell, 81
W. Salmon, M. Adams, C. Waterman-Storer (2002)
Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cellsThe Journal of Cell Biology, 158
Bruce Holitield, A. Ishihara, Ken Jacobson (1990)
Comparative behavior of membrane protein-antibody complexes on motile fibroblasts: implications for a mechanism of cappingThe Journal of Cell Biology, 111
Colin Choi, M. Vicente-Manzanares, Jessica Zareno, Leanna Whitmore, A. Mogilner, A. Horwitz (2008)
Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent mannerNature Cell Biology, 10
R. Keller (2005)
Cell migration during gastrulation.Current opinion in cell biology, 17 5
Chromatin Regulatory Mechanisms in
Daniel Starr, Heidi Fridolfsson (2010)
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.Annual review of cell and developmental biology, 26
T. Mitchison, M. Kirschner (1988)
Cytoskeletal dynamics and nerve growthNeuron, 1
M. Arnaout (2002)
Integrin structure: new twists and turns in dynamic cell adhesionImmunological Reviews, 186
J. Theriot, T. Mitchison (1992)
Comparison of actin and cell surface dynamics in motile fibroblastsThe Journal of Cell Biology, 119
S. Munevar, Yu-li Wang, M. Dembo (2001)
Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts.Biophysical journal, 80 4
M. Raftopoulou, A. Hall (2004)
Cell migration: Rho GTPases lead the way.Developmental biology, 265 1
C. Klämbt (2009)
Modes and regulation of glial migration in vertebrates and invertebratesNature Reviews Neuroscience, 10
Shelly Peyton, A. Putnam (2005)
Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashionJournal of Cellular Physiology, 204
N. Watanabe, T. Mitchison (2002)
Single-Molecule Speckle Analysis of Actin Filament Turnover in LamellipodiaScience, 295
B. Zimerman, T. Volberg, B. Geiger (2004)
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading.Cell motility and the cytoskeleton, 58 3
B. Geiger, J. Spatz, A. Bershadsky (2009)
Environmental sensing through focal adhesionsNature Reviews Molecular Cell Biology, 10
M. Gardel, B. Sabass, Lin Ji, G. Danuser, U. Schwarz, Clare Waterman (2008)
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speedThe Journal of Cell Biology, 183
L. Machesky, A. Hall (1997)
Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal ReorganizationThe Journal of Cell Biology, 138
K. Musunuru, I. Domian, K. Chien (2010)
Stem cell models of cardiac development and disease.Annual review of cell and developmental biology, 26
J. Small (1988)
The actin cytoskeleton.Electron microscopy reviews, 1 1
G. Maheshwari, Gillian Brown, D. Lauffenburger, A. Wells, L. Griffith (2000)
Cell adhesion and motility depend on nanoscale RGD clustering.Journal of cell science, 113 ( Pt 10)
N. Yamana, Y. Arakawa, Tomohiro Nishino, K. Kurokawa, Masahiro Tanji, Reina Itoh, J. Monypenny, T. Ishizaki, H. Bito, K. Nozaki, N. Hashimoto, M. Matsuda, S. Narumiya (2006)
The Rho-mDia1 Pathway Regulates Cell Polarity and Focal Adhesion Turnover in Migrating Cells through Mobilizing Apc and c-SrcMolecular and Cellular Biology, 26
C. Clainche, M. Carlier (2008)
Regulation of actin assembly associated with protrusion and adhesion in cell migration.Physiological reviews, 88 2
Q. Shi, D. Boettiger (2003)
A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397.Molecular biology of the cell, 14 10
Y. Sawada, M. Tamada, Benjamin Dubin-Thaler, Oksana Cherniavskaya, R. Sakai, Sakae Tanaka, M. Sheetz (2006)
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasCell, 127
J. Heath (1983)
Behaviour and structure of the leading lamella in moving fibroblasts. I. Occurrence and centripetal movement of arc-shaped microfilament bundles beneath the dorsal cell surface.Journal of cell science, 60
Jonathan Alberts, G. Odell (2004)
In Silico Reconstitution of Listeria Propulsion Exhibits Nano-SaltationPLoS Biology, 2
J. Friedland, Mark Lee, D. Boettiger (2009)
Mechanically Activated Integrin Switch Controls α5β1 FunctionScience, 323
T. Svitkina, E. Bulanova, O. Chaga, D. Vignjevic, S. Kojima, J. Vasiliev, G. Borisy (2003)
Mechanism of filopodia initiation by reorganization of a dendritic networkThe Journal of Cell Biology, 160
N. Medeiros, D. Burnette, P. Forscher (2006)
Myosin II functions in actin-bundle turnover in neuronal growth conesNature Cell Biology, 8
Xian Zhang, Guoying Jiang, Yunfei Cai, S. Monkley, D. Critchley, M. Sheetz (2008)
Talin depletion reveals independence of initial cell spreading from integrin activation and tractionNature Cell Biology, 10
V. Vogel, M. Sheetz (2006)
Local force and geometry sensing regulate cell functionsNature Reviews Molecular Cell Biology, 7
S. Schaub, S. Bohnet, V. Laurent, J. Meister, A. Verkhovsky (2007)
Comparative maps of motion and assembly of filamentous actin and myosin II in migrating cells.Molecular biology of the cell, 18 10
Santos Franco, M. Rodgers, B. Perrin, Jaewon Han, David Bennin, D. Critchley, A. Huttenlocher (2004)
Calpain-mediated proteolysis of talin regulates adhesion dynamicsNature Cell Biology, 6
K. Beningo, M. Dembo, I. Kaverina, V. Small, Yu-li Wang (2001)
Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating FibroblastsThe Journal of Cell Biology, 153
A. Ridley, A. Hall (1992)
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsCell, 70
M. Vicente-Manzanares, Jessica Zareno, Leanna Whitmore, Colin Choi, A. Horwitz (2007)
Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cellsThe Journal of Cell Biology, 176
W. Thomas (2008)
Catch bonds in adhesion.Annual review of biomedical engineering, 10
K. Burridge, Sarita Sastry, Jennifer Sallee (2006)
Regulation of Cell Adhesion by Protein-tyrosine PhosphatasesJournal of Biological Chemistry, 281
N. Gallant, K. Michael, Andrés García (2005)
Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly.Molecular biology of the cell, 16 9
H. Yamaguchi, J. Wyckoff, J. Condeelis (2005)
Cell migration in tumors.Current opinion in cell biology, 17 5
T. Oliver, M. Dembo, K. Jacobson (1999)
Separation of Propulsive and Adhesive Traction Stresses in Locomoting KeratocytesThe Journal of Cell Biology, 145
D. Rose, R. Alon, M. Ginsberg (2007)
Integrin modulation and signaling in leukocyte adhesion and migrationImmunological Reviews, 218
C. Ballestrem, N. Erez, J. Kirchner, Z. Kam, A. Bershadsky, B. Geiger (2006)
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transferJournal of Cell Science, 119
S. Gupton, F. Gertler (2007)
Filopodia: The Fingers That Do the WalkingScience's STKE, 2007
J. Theriot, T. Mitchison (1991)
Actin microfilament dynamics in locomoting cellsNature, 352
Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement, these processes must be spatiotemporally coordinated. To a large degree, the morphological changes and physical forces that occur during migration are generated by a dynamic filamentous actin (F-actin) cytoskeleton. Adhesion is regulated by dynamic assemblies of structural and signaling proteins that couple the F-actin cytoskeleton to the extracellular matrix. Here, we review current knowledge of the dynamic organization of the F-actin cytoskeleton in cell migration and the regulation of focal adhesion assembly and disassembly with an emphasis on how mechanical and biochemical signaling between these two systems regulate the coordination of physical processes in cell migration.
Annual Review of Cell and Developmental Biology – Annual Reviews
Published: Nov 10, 2010
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