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Purpose. Drug targeting to activated endothelial cells is now being explored as a new approach to interfere with chronic inflammation. This study compares a dexamethasone-anti-E-selectin immunoconjugate (dexa-AbEsel) with anti-E-selectin immunoliposomes (AbEsel-immunoliposomes) that contain dexamethasone, regarding in vitro binding and internalization as well as in vivo accumulation in activated endothelial cells.
Pharmaceutical Research – Springer Journals
Published: Oct 7, 2004
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