Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Chou, P. Talalay (1983)
Analysis of combined drug effects: a new look at a very old problemTrends in Pharmacological Sciences, 4
M. Masu, Y. Tanabe, K. Tsuchida, R. Shigemoto, S. Nakanishi (1991)
Sequence and expression of a metabotropic glutamate receptorNature, 349
D. Schoepp, Bryan Johnson, C. Salhoff, J. Mcdonald, M. Johnston (1991)
In Vitro and In Vivo Pharmacology of trans‐ and cis‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylic Acid: Dissociation of Metabotropic and Ionotropic Excitatory Amino Acid Receptor EffectsJournal of Neurochemistry, 56
F. Gusovsky, J. Gutkind (1991)
Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation.Molecular pharmacology, 39 2
E. Layne (1957)
SPECTROPHOTOMETRIC AND TURBIDIMETRIC METHODS FOR MEASURING PROTEINSMethods in Enzymology, 3
M. Desai, P. Conn (1991)
Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition.Journal of neurophysiology, 66 1
K. Curry, M. Peet, D. Magnuson, H. Mclennan (1988)
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid.Journal of medicinal chemistry, 31 4
Smart Smart (1989)
Excitatory amino acids: involvement of second messengers in the signal transduction processCell. Mol. Neurobiol., 9
D. Schoepp, B. Johnson, R. True, J. Monn (1991)
Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis.European journal of pharmacology, 207 4
(1990)
IS,3R-ACPD stimulates and L-AP~
R. Stein, R. Pinkas-Kramarski, M. Sokolovsky (1988)
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.The EMBO Journal, 7
D. Schoepp, Joël Bockaert, Fritz Sladeczek (1990)
Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors.Trends in pharmacological sciences, 11 12
A. Irving, J. Schofield, J. Watkins, D. Sunter, G. Collingridge (1990)
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons.European journal of pharmacology, 186 2-3
E. Palmer, D. Monaghan, C. Cotman (1989)
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.European journal of pharmacology, 166 3
N. Schaad, M. Schorderet, P. Magistretti (1990)
Modulation of VIP‐Stimulated cAMP Formation by Excitatory Amino Acids in Mouse Cerebral CortexEuropean Journal of Neuroscience, 2
Abstract: It is well documented that the effects of excitatory ammo acid (EAA) agonists on phosphoinositide hydrolysis involve a GTP‐binding protein‐linked or “metabotropic’ receptor mechanism. The mechanisms by which EAAs alter cyclic AMP levels in brain slices, however, are not yet clear. In this study, the selective metabotropic EAA agonist trans‐(±)‐l‐aminocyclopentane‐l,3‐dicarboxylic acid and its isomers were examined for effects on basal and forskolin‐stimulated cyclic AMP formation in slices of the rat hippocampus. Trans‐(±)‐l‐Aminocyclopentane‐l,3‐dicarboxylic acid had little effect on basal cyclic AMP but inhibited forskolin‐stimulated cyclic AMP formation in a biphasic manner. The 1S,3R isomer of 1‐aminocy‐clopentane‐l,3‐dicarboxylic acid produced potent but only partial (~50%) inhibition of forskolin‐stimulated cyclic AMP formation. 1R,3S–l‐Aminocyclopentane‐l,3‐dicarboxylic acid fully inhibited forskolin‐stimulated cyclic AMP but with lower potency than the IS,3R isomer. These results show that in addition to the formation of phosphoinositide‐derived second messengers, the cellular consequences of selectively activating hippocampal metabotropic EAA receptors include an alteration of cellular cyclic AMP levels.
Journal of Neurochemistry – Wiley
Published: Mar 1, 1992
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.