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Abstract Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (S I ) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for ∼45 min at 65–80% peak O 2 consumption) with no loss of body mass (PRE, 91.9 ± 3.8 kg vs. POST, 91.6 ± 3.9 kg) or fat mass (PRE, 26.5 ± 1.8 kg vs. POST, 26.7 ± 2.2 kg). Insulin action significantly ( P < 0.05) improved with exercise training (S I +98%); however, plasma adiponectin concentration did not change (PRE, 6.3 ± 1.5 μg/ml vs. POST, 6.6 ± 1.8 μg/ml). In contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adiponectin (+281%), which was accompanied by enhanced insulin action (S I , +432%). These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity. weight loss Footnotes Address for reprint requests and other correspondence: M. W. Hulver, Dept. of Physiology, The Brody School of Medicine, 7W-44 Brody Medical Sciences Bldg., East Carolina University, Greenville, NC 27858 (E-mail: hulverm@mail.ecu.edu ). The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 10.1152/ajpendo.00150.2002 Copyright © 2002 the American Physiological Society
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Oct 1, 2002
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