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Subcellular distribution of the inositol 1,4,5‐trisphosphate receptors: functional relevance and molecular determinants

Subcellular distribution of the inositol 1,4,5‐trisphosphate receptors: functional relevance and... Abstract The inositol 1,4,5‐trisphosphate receptor (IP3R) is an intracellular Ca2+ channel that is for the largest part expressed in the endoplasmic reticulum. Its precise subcellular localization is an important factor for the correct initiation and propagation of Ca2+ signals. The relative position of the IP3Rs, and thus of the IP3‐sensitive Ca2+ stores, to mitochondria, nucleus or plasma membrane determines in many cases the physiological consequences of IP3‐induced Ca2+ release. Most cell types express more than one IP3R isoform and their subcellular distribution is cell‐type dependent. Moreover, it was recently demonstrated that depending on the physiological status of the cell redistribution of IP3Rs and/or of IP3‐sensitive Ca2+ stores could occur. This indicates that the cell must be able to regulate not only IP3R expression but also its distribution. The various proteins potentially determining IP3R localization and redistribution will therefore be discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biology of the Cell Wiley

Subcellular distribution of the inositol 1,4,5‐trisphosphate receptors: functional relevance and molecular determinants

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References (171)

Publisher
Wiley
Copyright
2004 Société Française des Microscopies and Société Biologie Cellulaire de France
ISSN
0248-4900
eISSN
1768-322X
DOI
10.1016/j.biolcel.2003.11.004
pmid
15093123
Publisher site
See Article on Publisher Site

Abstract

Abstract The inositol 1,4,5‐trisphosphate receptor (IP3R) is an intracellular Ca2+ channel that is for the largest part expressed in the endoplasmic reticulum. Its precise subcellular localization is an important factor for the correct initiation and propagation of Ca2+ signals. The relative position of the IP3Rs, and thus of the IP3‐sensitive Ca2+ stores, to mitochondria, nucleus or plasma membrane determines in many cases the physiological consequences of IP3‐induced Ca2+ release. Most cell types express more than one IP3R isoform and their subcellular distribution is cell‐type dependent. Moreover, it was recently demonstrated that depending on the physiological status of the cell redistribution of IP3Rs and/or of IP3‐sensitive Ca2+ stores could occur. This indicates that the cell must be able to regulate not only IP3R expression but also its distribution. The various proteins potentially determining IP3R localization and redistribution will therefore be discussed.

Journal

Biology of the Cell – Wiley

Published: Feb 1, 2004

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