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J Hutchison, C. Beyer, R. Hutchison, A. Wozniak (1997)
Sex differences in the regulation of embryonic brain aromataseThe Journal of Steroid Biochemistry and Molecular Biology, 61
Barrett-Connor (1991)
Estrogen and coronary heart disease in women [see comments]JAMA, 265
A. Vockel, E. Pröve, J. Balthazart (1990)
Sex- and age-related differences in the activity of testosterone-metabolizing enzymes in microdissected nuclei of the zebra finch brainBrain Research, 511
Y. Goodman, A. Bruce, B. Cheng, M. Mattson (1996)
Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal NeuronsJournal of Neurochemistry, 66
Renata Rusa, N. Alkayed, Barbara Crain, R. Traystman, A. Kimes, E. London, Judith Klaus, P. Hurn (1999)
17beta-estradiol reduces stroke injury in estrogen-deficient female animals.Stroke, 30 8
E. Barrett-Connor, T. Bush (1991)
Estrogen and coronary heart disease in womenInternational Journal of Gynecology & Obstetrics, 37
G. Callard, B. Schlinger, M. Pasmanik (1990)
Nonmammalian vertebrate models in studies of brain-steroid interactions.The Journal of experimental zoology. Supplement : published under auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry, 4
J. Bishop, J. Simpkins (1994)
Estradiol Treatment Increases Viability of Glioma and Neuroblastoma Cells in VitroMolecular and Cellular Neuroscience, 5
B. Schlinger, A. Arnold (1991)
Brain is the major site of estrogen synthesis in a male songbird.Proceedings of the National Academy of Sciences of the United States of America, 88
A. Foidart, B. Silverin, M. Baillien, N. Harada, J. Balthazart (1998)
Neuroanatomical Distribution and Variations across the Reproductive Cycle of Aromatase Activity and Aromatase-Immunoreactive Cells in the Pied Flycatcher (Ficedula hypoleuca)Hormones and Behavior, 33
E. Lephart (1996)
A review of brain aromatase cytochrome P450Brain Research Reviews, 22
T. Nguyen, E. Frank, D. Trunkey (1996)
Steroids in central nervous system injury.Advances in surgery, 30
H. Díaz, A. Lorenzo, H. Carrer, A. Cáceres (1992)
Time lapse study of neurite growth in hypothalamic dissociated neurons in culture: Sex differences and estrogen effectsJournal of Neuroscience Research, 33
C. Woolley, B. Mcewen (1992)
Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992 Oct;12(10):following table of contents], 12
B. Schlinger, G. Callard (1989)
Aromatase activity in quail brain: correlation with aggressiveness.Endocrinology, 124 1
M. Contreras, J. Wade (1999)
Interactions between nerve growth factor binding and estradiol in early development of the zebra finch telencephalon.Journal of neurobiology, 40 2
E. Jacobs, A. Arnold, A. Campagnoni (1996)
Zebra finch estrogen receptor cDNA: Cloning and mRNA expressionThe Journal of Steroid Biochemistry and Molecular Biology, 59
T. Whittingham, W. Lust, J. Passonneau (1984)
An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice, 4
J. Balthazart, P. Absil, A. Foidart, M. Houbart, N. Harada, Gregory Ball (1996)
Distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): implications for the neural action of steroids and nuclear definition in the avian hypothalamus.Journal of neurobiology, 31 2
K. Suyama, K. Saito, Guang Chen, B. Pan, H. Manji, W. Potter (1995)
Alterations in Cyclic AMP Generation and G Protein Subunits following Transient Ischemia in Gerbil HippocampusJournal of Cerebral Blood Flow & Metabolism, 15
Colin Saldanha, Nicola Clayton, B. Schlinger (1999)
Androgen metabolism in the juvenile oscine forebrain: a cross-species analysis at neural sites implicated in memory function.Journal of neurobiology, 40 3
C. Singer, K. Rogers, T. Strickland, D. Dorsa (1996)
Estrogen protects primary cortical neurons from glutamate toxicityNeuroscience Letters, 212
B. McEwen (1999)
Clinical review 108: The molecular and neuroanatomical basis for estrogen effects in the central nervous system.The Journal of clinical endocrinology and metabolism, 84 6
Christian Behl, T. Skutella, Frank Lezoualc’h, A. Post, M. Widmann, Christopher Newton, Florian Holsboer (1997)
Neuroprotection against oxidative stress by estrogens: structure-activity relationship.Molecular pharmacology, 51 4
Thomas Toung, R. Traystman, P. Hurn (1998)
Estrogen-mediated neuroprotection after experimental stroke in male rats.Stroke, 29 8
T. Devoogd, F. Nottebohm (1981)
Sex differences in dendritic morphology of a song control nucleus in the canary: A quantitative Golgi studyJournal of Comparative Neurology, 196
J. Canick, D. Vaccaro, Elizabeth Livingston, S. Leeman, K. Ryan, T. Fox (1986)
Localization of aromatase and 5α-reductase to neuronal and non-neuronal cells in the fetal rat hypothalamusBrain Research, 372
Tegner Stokes, C. Leonard, F. Nottebohm (1974)
The telencephalon, diencephalon, and mesencephalon of the canary, Serinus canaria, in stereotaxic coordinatesJournal of Comparative Neurology, 156
A. Poletti, P. Negri‐Cesi, R. Melcangi, A. Colciago, L. Martini, F. Celotti (1997)
Expression of Androgen‐Activating Enzymes in Cultured Cells of Developing Rat BrainJournal of Neurochemistry, 68
C. Beyer, J Hutchison (1997)
Androgens stimulate the morphological maturation of embryonic hypothalamic aromatase-immunoreactive neurons in the mouse.Brain research. Developmental brain research, 98 1
M. Burek, K. Nordeen, E. Nordeen (1995)
Estrogen promotes neuron addition to an avian song-control nucleus by regulating post-mitotic events.Brain research. Developmental brain research, 85 2
F. Naftolin, T. Horvath, R. Jakab, C. Léránth, N. Harada, J. Balthazart (1996)
Aromatase immunoreactivity in axon terminals of the vertebrate brain. An immunocytochemical study on quail, rat, monkey and human tissues.Neuroendocrinology, 63 2
P. Green, K. Gridley, J. Simpkins (1996)
Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cellsNeuroscience Letters, 218
C. Toran-Allerand (1996)
The estrogen/neurotrophin connection during neural development: is co-localization of estrogen receptors with the neurotrophins and their receptors biologically relevant?Developmental neuroscience, 18 1-2
Alonso (1998)
Gonadal steroids and neuronal functionNeurochem Res, 23
C. Saldanha, M. Tuerk, Yong‐Hwan Kim, A. Fernandes, A. Arnold, B. Schlinger (2000)
Distribution and regulation of telencephalic aromatase expression in the zebra finch revealed with a specific antibodyJournal of Comparative Neurology, 423
A. Arnold, R. Gorski (1984)
Gonadal steroid induction of structural sex differences in the central nervous system.Annual review of neuroscience, 7
L. Garcia-Segura, A. Wozniak, Í. Azcoitia, J. Rodríguez, R. Hutchison, J. Hutchison (1999)
Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repairNeuroscience, 89
T. Devoogd, F. Nottebohm (1981)
Gonadal hormones induce dendritic growth in the adult avian brain.Science, 214 4517
R. Jakab, T. Horvath, C. Léránth, N. Harada, F. Naftolin (1993)
Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive “limbic ring” of the lateral septum-bed nucleus-amygdala complexThe Journal of Steroid Biochemistry and Molecular Biology, 44
B. McEwen (1999)
The Molecular and Neuroanatomical Basis for Estrogen Effects in the Central Nervous SystemThe Journal of Clinical Endocrinology and Metabolism, 84
B. Morrison, J. Eberwine, D. Meaney, T. Mcintosh (2000)
Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridizationNeuroscience, 96
N. Alkayed, I. Harukuni, A. Kimes, E. London, R. Traystman, P. Hurn (1998)
Gender-linked brain injury in experimental stroke.Stroke, 29 1
A. Álvarez-Buylla, C. Ling, Wen Yu (1994)
Contribution of neurons born during embryonic and adult life to the brain of adult canaries: Regional specificity and delayed birth of neurons in the song‐control nucleiJournal of Comparative Neurology, 347
C. Saldanha, P. Popper, P. Micevych, B. Schlinger (1998)
The Passerine Hippocampus is a Site of High Aromatase: Inter- and Intraspecies ComparisonsHormones and Behavior, 34
I. Zwain, S. Yen, C. Cheng (1997)
Astrocytes cultured in vitro produce estradiol-17beta and express aromatase cytochrome P-450 (P-450 AROM) mRNA.Biochimica et biophysica acta, 1334 2-3
J. Balthazart, O. Tlemçani, G. Ball (1996)
Do Sex Differences in the Brain Explain Sex Differences in the Hormonal Induction of Reproductive Behavior? What 25 Years of Research on the Japanese Quail Tells UsHormones and Behavior, 30
F. Freking, B. Ramachandran, B. Schlinger (1998)
Regulation of aromatase, 5?- and 5?-reductase in primary cell cultures of developing zebra finch telencephalonJournal of Neurobiology, 36
Peter Shen, B. Schlinger, A. Campagnoni, A. Arnold (1995)
An atlas of aromatase mRNA expression in the zebra finch brainJournal of Comparative Neurology, 360
Andrea Hidalgo, K. Barami, K. Iversen, Steven Goldman (1995)
Estrogens and non-estrogenic ovarian influences combine to promote the recruitment and decrease the turnover of new neurons in the adult female canary brain.Journal of neurobiology, 27 4
J. Simpkins, P. Green, K. Gridley, Meharvan Singh, N. Fiebre, Gopal Rajakumar (1997)
Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease.The American journal of medicine, 103 3A
N. MacLusky, F. Naftolin (1981)
Sexual differentiation of the central nervous system.Science, 211 4488
B. Schlinger, S. Amur‐Umarjee, P. Shen, A. Campagnoni, A. Arnold (1994)
Neuronal and non-neuronal aromatase in primary cultures of developing zebra finch telencephalon, 14
D. Hovda, S. Lee, M. Smith, S. Stuck, M. Bergsneider, D. Kelly, E. Shalmon, N. Martin, M. Caron, J. Mazziotta (1995)
The neurochemical and metabolic cascade following brain injury: moving from animal models to man.Journal of neurotrauma, 12 5
C. Toran-Allerand, K. Hashimoto, William Greenough, Mario Saltarelli (1983)
Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro: III. Effects of estrogen on dendritic differentiation.Brain research, 283 1
K. Shinoda, H. Yagi, H. Fujita, Y. Osawa, Y. Shiotani (1989)
Screening of aromatase‐containing neurons in rat forebrain: An immunohistochemical study with antibody against human placental antigen x‐P2 (hPAX‐P2)Journal of Comparative Neurology, 290
The expression of aromatase (oestrogen synthase) within the vertebrate central nervous system (CNS) is key in the provision of local oestrogens to neural circuits. Aromatase expression appears to be exclusively neuronal under normal conditions. However, some in vitro studies suggest the presence of astrocytic aromatase in songbirds and mammals. Recently, aromatase in reactive astrocytes has been demonstrated in response to neural injury in the mammalian CNS. Since the glial aromatase expression first documented in cultures of the songbird telencephalon may reflect processes similar to those in response to mammalian neural injury, we investigated whether injury alters the pattern of aromatase‐expression in the zebra finch, a species with very high levels of forebrain aromatase expression. Adult males received a penetrating neural injury to the right hemisphere and were killed either 24 or 72 h later. Controls were anaesthetized and otherwise unmanipulated. We determined the expression of aromatase mRNA and protein using in situ hybridization and immunocytochemistry, respectively. Both the transcription and translation of aromatase is dramatically upregulated around the lesion site in response to neural injury in the zebra finch forebrain. This effect is robust and rapid, occurring within 24 h of the injury itself. Cells that upregulate aromatase appear to be reactive astrocytes based upon morphology. The hemisphere contralateral to the injury and both hemispheres in control birds showed the normal, exclusively neuronal pattern of aromatase expression. The upregulation of aromatase in astrocytes may provide high levels of oestrogen available to modulate processes such as CNS repair. Injury‐induced upregulation of astrocytic aromatase may be a general characteristic of the injured vertebrate brain.
Journal of Neuroendocrinology – Wiley
Published: Apr 1, 2001
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