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Mechanisms by which mitochondria transport calcium

Mechanisms by which mitochondria transport calcium calcium THOMAS E. GUNTER AND DOUGLAS R. PFEIFFER Department Biophysics, University Rochester, Rochester, New York 14642; and The Hormel Institute, University Minnesota, Austin, Minnesota 55912 GUNTER, THOMAS E., AND DOUGLAS R. PFEIFFER. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258 (Cell Physiol. 27): C755-C786,1990.-It has been firmly established that the rapid uptake Ca2’ by mitochondria from a wide range sources is mediated by a uniporter which permits transport the ion down its electrochemical gradient. Several mechanisms Ca2’ efflux from mitochondria have also been extensively discussed in the literature. Energized mitochondria must expend a significant amount energy to transport Ca2’ against its electrochemical gradient from the matrix space to the external space. Two separate mechanisms have been found to mediate this outward transport: a Ca”‘/ nNa+ exchanger and a Na’-independent efflux mechanism. These efflux mechanisms are considered from the perspective available energy. In addition, a reversible Ca2+-induced increase in inner membrane permeability can also occur. The induction this permeability transition is characterized by swelling the mitochondria, leakiness to small ions such as K+, membrane potential. It has Mg2+, and Ca”‘, and loss the mitochondrial been suggested that the permeability transition and its reversal may also function as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Mechanisms by which mitochondria transport calcium

AJP - Cell Physiology , Volume 258: C755 – May 1, 1990

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Publisher
The American Physiological Society
Copyright
Copyright © 1990 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
See Article on Publisher Site

Abstract

calcium THOMAS E. GUNTER AND DOUGLAS R. PFEIFFER Department Biophysics, University Rochester, Rochester, New York 14642; and The Hormel Institute, University Minnesota, Austin, Minnesota 55912 GUNTER, THOMAS E., AND DOUGLAS R. PFEIFFER. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258 (Cell Physiol. 27): C755-C786,1990.-It has been firmly established that the rapid uptake Ca2’ by mitochondria from a wide range sources is mediated by a uniporter which permits transport the ion down its electrochemical gradient. Several mechanisms Ca2’ efflux from mitochondria have also been extensively discussed in the literature. Energized mitochondria must expend a significant amount energy to transport Ca2’ against its electrochemical gradient from the matrix space to the external space. Two separate mechanisms have been found to mediate this outward transport: a Ca”‘/ nNa+ exchanger and a Na’-independent efflux mechanism. These efflux mechanisms are considered from the perspective available energy. In addition, a reversible Ca2+-induced increase in inner membrane permeability can also occur. The induction this permeability transition is characterized by swelling the mitochondria, leakiness to small ions such as K+, membrane potential. It has Mg2+, and Ca”‘, and loss the mitochondrial been suggested that the permeability transition and its reversal may also function as

Journal

AJP - Cell PhysiologyThe American Physiological Society

Published: May 1, 1990

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