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M. Nieto‐Sampedro, E. Lewis, C. Cotman, M. Manthorpe, S. Skaper, G. Barbin, F. Longo, S. Varon (1982)
Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site.Science, 217 4562
R. Schnaar, A. Schaffner (1981)
Separation of cell types from embryonic chicken and rat spinal cord: characterization of motoneuron-enriched fractions, 1
K. Landa, R. Adler, M. Manthorpe, S. Varon (1980)
Cholinergic neuronotrophic factors. III. Developmental increase of trophic activity for chick embryo ciliary ganglion neurons in their intraocular target tissues.Developmental biology, 74 2
D. Kligman (1982)
Neurite outgrowth from cerebral cortical neurons is promoted by medium conditioned over heart cellsJournal of Neuroscience Research, 8
J. Slack, S. Pockett (1982)
Motor neurotrophic factor in denervated adult skeletal muscleBrain Research, 247
M. Manthorpe, S. Skaper, R. Adler, K. Landa, S. Varon (1980)
Cholinergic Neuronotrophic Factors: Fractionation Properties of an Extract from Selected Chick Embryonic Eye TissuesJournal of Neurochemistry, 34
P. O'lague, K. Obata, P. Claude, E. Furshpan, D. Potter (1974)
Evidence for cholinergic synapses between dissociated rat sympathetic neurons in cell culture.Proceedings of the National Academy of Sciences of the United States of America, 71 9
M. Manthorpe, G. Barbin, S. Varon (1982)
Isoelectric focusing of the chick eye ciliary neuronotrophic factorJournal of Neuroscience Research, 8
R. Adler, M. Manthorpe, S. Varon (1982)
Lectin reactivity of PNPF, a polyornithine-binding neurite-promoting factor.Brain research, 282 1
R. Nishi, D. Berg (1979)
Survival and development of ciliary ganglion neurones grown alone in cell cultureNature, 277
E. Furshpan, P. MacLeish, P. O'lague, D. Potter (1976)
Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures: evidence for cholinergic, adrenergic, and dual-function neurons.Proceedings of the National Academy of Sciences of the United States of America, 73 11
M. Bothwell (1982)
Insulin and somatemedin MSA promote nerve growth factor‐independent neurite formation by cultured chick dorsal root ganglionic sensory neuronsJournal of Neuroscience Research, 8
L. Dribin, J. Barrett (1982)
Characterization of neuritic outgrowth-promoting activity of conditioned medium on spinal cord explants.Brain research, 256 4
L. Landmesser, G. Pilar (1974)
Synaptic transmission and cell death during normal ganglionic developmentThe Journal of Physiology, 241
K. Crutcher, F. Collins (1982)
In vitro Evidence for two distinct hippocampal growth factors: basis of neuronal plasticity?Science, 217 4554
L. Dribin, J. Barrett (1980)
Conditioned medium enhances neuritic outgrowth from rat spinal cord explants.Developmental biology, 74 1
Y. Barde, D. Edgar, H. Thoenen (1980)
Sensory neurons in culture: changing requirements for survival factors during embryonic development.Proceedings of the National Academy of Sciences of the United States of America, 77 2
S. Varon, R. Adler (1981)
Trophic and Specifying Factors Directed to Neuronal CellsAdvances in Cell Biology, 2
Frank Collins (1980)
Neurite outgrowth induced by the substrate associated material from nonneuronal cells.Developmental biology, 79 1
A. Lander, D. Fujii, D. Gospodarowicz, L. Reichardt (1982)
Characterization of a factor that promotes neurite outgrowth: evidence linking activity to a heparan sulfate proteoglycanThe Journal of Cell Biology, 94
R. Campenot, R. Campenot (1982)
Development of sympathetic neurons in compartmentalized cultures. II. Local control of neurite survival by nerve growth factor.Developmental biology, 93 1
N. Carri, Ted Ebendal (1983)
Organotypic cultures of neural retina: neurite outgrowth stimulated by brain extracts.Brain research, 282 3
D. Edgar, Y. Barde, H. Thoenen (1981)
Subpopulations of cultured chick sympathetic neurones differ in their requirements for survival factorsNature, 289
H. Müller, W. Seifert (1982)
A neurotrophic factor (NTF) released from primary glial cultures supports survival and fiber outgrowth of cultured hippocampal neuronsJournal of Neuroscience Research, 8
M. Manthorpe, S. Varon, R. Adler (1982)
Neurite‐Promoting Factor in Conditioned Medium from RN22 Schwannoma Cultures: Bioassay, Fractionation, and PropertiesJournal of Neurochemistry, 37
C. Ko, H. Burton, Mary Johnson, R. Bunge (1976)
Synaptic transmission between rat superior cervical ganglion neurons in dissociated cell culturesBrain Research, 117
T. Ebendal, K. Hedlund, G. Norrgren (1982)
Nerve growth factors in chick tissuesJournal of Neuroscience Research, 8
Frank Collins (1978)
Axon initiation by ciliary neurons in culture.Developmental biology, 65 1
C. Henderson, M. Huchet, J. Changeux (1981)
Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells.Proceedings of the National Academy of Sciences of the United States of America, 78 4
R. Adler, S. Varon (1980)
Cholinergic neuronotrophic factors: V. Segregation of survival- and neurite-promoting activities in heart-conditioned mediaBrain Research, 188
J. Turner, R. Delaney, James Johnson (1981)
Retinal ganglion cell response to axotomy and nerve growth factor antiserum treatment in the regenerating visual system of the goldfish (Carassius auratus): An in vivo and in vitro analysisBrain Research, 204
P. Patterson, L. Chun (1977)
The induction of acetylcholine synthesis in primary cultures of dissociated rat sympathetic neurons. I. Effects of conditioned medium.Developmental biology, 56 2
R. Adler, S. Varon (1982)
Neuronal survival in intact ciliary ganglia in vivo and in vitro: ciliary neuronotrophic factor as a target surrogate.Developmental biology, 92 2
Yves Barde, Ronald Lindsay, D. Monard, Hans Thoenen (1978)
New factor released by cultured glioma cells supporting survival and growth of sensory neuronesNature, 274
H. Thoenen, Y. Barde (1980)
Physiology of nerve growth factor.Physiological reviews, 60 4
Earl Godfrey, B. Schrier, Phillip Nelson (1980)
Source and target cell specificities of a conditioned medium factor that increases choline acetyltransferase activity in cultured spinal cord cells.Developmental biology, 77 2
R. Bonyhady, I. Hendry, C. Hill (1982)
Reversible dissociation of a bovine cardiac factor that supports survival of avian ciliary ganglionic neuronesJournal of Neuroscience Research, 7
V. Nurcombe, M. Bennett (1982)
Evidence for neuron-survival and neurite-promoting factors from skeletal muscle: Their effects on embryonic spinal cordNeuroscience Letters, 34
R. Levi‐montalcini (1982)
Developmental neurobiology and the natural history of nerve growth factor.Annual review of neuroscience, 5
J. Tuttle, J. Suszkiw, M. Ard (1980)
Long-term survival and development of dissociated parasympathetic neurons in cultureBrain Research, 183
T. Ebendal (1981)
Control of neurite extension by embryonic heart explants.Journal of embryology and experimental morphology, 61
David Edgar, Hans Thoenen (1982)
Modulation of NGF-induced survival of chick sympathetic neurons by contact with a conditioned medium factor bound to the culture substrate.Brain research, 281 1
R. Adler, M. Manthorpe, S. Skaper, S. Varon (1981)
Polyornithine-attached neurite-promoting factors (PNPFs). Culture sources and responsive neuronsBrain Research, 206
Michael Coughlin, E. Bloom, Ira Black (1981)
Characterization of a neuronal growth factor from mouse heart-cell-conditioned medium.Developmental biology, 82 1
H. Tanaka, M. Sakai, K. Obata (1982)
Effects of serum, tissue extract, conditioned medium, and culture substrata on neurite appearance from spinal cord explants of chick embryo.Brain research, 256 3
P. Walicke, P. Patterson (1981)
On the role of Ca2+ in the transmitter choice made by cultured sympathetic neurons, 1
Ted Ebendal (1979)
Stage-dependent stimulation of neurite outgrowth exerted by nerve growth factor and chick heart in cultured embryonic ganglia.Developmental biology, 72 2
N. Douarin, J. Smith, C. Lièvre (1981)
From the neural crest to the ganglia of the peripheral nervous system.Annual review of physiology, 43
R. Lindsay, Janice Tarbit (1979)
Developmentally regulated induction of neurite outgrowth from immature chick sensory neurons (DRG) by homogenates of avian or mammalian heart, liver and brainNeuroscience Letters, 12
K. Obata, Hideaki Tanaka (1980)
Conditioned medium promotes neurite growth from both central and peripheral neuronsNeuroscience Letters, 16
M. Manthorpe, F. Longo, S. Varon (1982)
Comparative features of spinal neuronotrophic factors in fluids collected in vitro and in vivoJournal of Neuroscience Research, 8
C. Hill, I. Hendry, R. Bonyhady (1981)
Avian parasympathetic neurotrophic factors: age-related increases and lack of regional specificity.Developmental biology, 85 1
E. Giller, J. Neale, P. Bullock, B. Schrier, P. Nelson (1977)
Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned mediumThe Journal of Cell Biology, 74
R. Adler, K. Landa, M. Manthorpe, S. Varon (1979)
Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons.Science, 204 4400
S. Varon, M. Manthorpe (1982)
Schwann Cells: An in Vitro PerspectiveAdvances in Cell Biology, 3
M. Bennett, K. Lai, V. Nurcombe (1980)
Identification of embryonic motoneurons in vitro: their survival is dependent on skeletal muscleBrain Research, 190
The complexity and remarkable specificity found in the nervous system chal lenge the investigator to identify molecular mechanisms guiding neuronal development. Cell-cell interactions mediated by diffusible substances have frequently been suggested to play an important role. Studies on naturally occurring cell death in the nervous system provided early evidence for such interactions by demonstrating that neuronal survival beyond a critical period in development requires interaction between the neurons and the postsynaptic target tissue (for a review see Oppenheim 1981). The discovery of Nerve Growth Factor (NGF) raised the possibility that neuronal development, includ ing target-dependent neuronal survival, might be mediated by diffusible mole cules. NGF can be isolated as a 140,000 dalton protein complex ( 7S NGF) of heterologous subunits or as a 26,500 dalton component (beta-NGF) containing two identical polypeptide chains. Experiments in vivo indicate that NGF can reverse naturally occurring as well as experimentally induced cell death in sympathetic and sensory neurons; moreover, anti-NGF antibodies in vivo can block the development of the s ympatheti c nervous system (for reviews see Thoenen & Barde 1980, Hamburger et al 1981, Levi-Monta1cini 1982). That NGF might also influence the choice of targets contacted by neurons is suggested by
Annual Review of Neuroscience – Annual Reviews
Published: Mar 1, 1984
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