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Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus 213 101 101 1 1 P. Whitton G. Curzon Department of Neurochemistry Institute of Neurology Queen Square WC1N 3BG London UK School of Pharmacy Brunswick Square WC1N 1AX London UK Abstract 1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT 1C receptors with an ED 50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

Whitton, P.; Curzon, G.
Psychopharmacology , Volume 101 (1) – Mar 1, 1990
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References (19)

Publisher
Springer Journals
Copyright
Copyright © 1990 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245806
Publisher site
See Article on Publisher Site

Abstract

213 101 101 1 1 P. Whitton G. Curzon Department of Neurochemistry Institute of Neurology Queen Square WC1N 3BG London UK School of Pharmacy Brunswick Square WC1N 1AX London UK Abstract 1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT 1C receptors with an ED 50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety.

Journal

Psychopharmacology – Springer Journals

Published: Mar 1, 1990

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