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K. Brunner, J. Cerottini (1971)
Cytotoxic Lymphocytes as Effector Cells of Cell-Mediated Immunity*
L. Cohen, M. Howe (1973)
Synergism between subpopulations of thymus-derived cells mediating the proliferative and effector phases of the mixed lymphocyte reaction.Proceedings of the National Academy of Sciences of the United States of America, 70 9
S. Cullen, B. Schwartz, S. Nathenson, M. Cherry (1972)
The molecular basis of codominant expression of the histocompatibility-2 genetic region.Proceedings of the National Academy of Sciences of the United States of America, 69 6
C. Henney, J. Bubbers (1973)
Antigen-T lymphocyte interactions: inhibition by cytochalasin B.Journal of immunology, 111 1
H. Folch, M. Yoshinaga, B. Waksman (1973)
Regulation of lymphocyte responses in vitro. 3. Inhibition by adherent cells of the T-lymphocyte response to phytohemagglutinin.Journal of immunology, 110 3
P. Gorer, Z. Mikulska (1959)
Some further data on the H-2 system of antigensProceedings of the Royal Society of London. Series B. Biological Sciences, 151
F. Bach, M. Segall, K. Zier, P. Sondel, B. Alter, M. Bach (1973)
Cell Mediated Immunity: Separation of Cells Involved in Recognitive and Destructive PhasesScience, 180
K. Abbasi, H. Festenstein (1973)
Antigenic strength investigated by cell‐mediated lympholysis in miceEuropean Journal of Immunology, 3
F. Bach, M. Widmer, M. Segall, M. Bach, J. Klein (1972)
Genetic and Immunological Complexity of Major Histocompatibility RegionsScience, 176
M. Widmer, B. Alter, Fritz Bach, M. Bach, D. Bailey (1973)
Lymphocyte reactivity to serologically undetected components of the major histocompatibility complex.Nature: New biology, 242 121
C. Néauport‐Sautès, D. Silvestre, F. Lilly, F. Kourilsky (1973)
Molecular independence of H-2K and H-2D antigens on the cell surface.Transplantation proceedings, 5 1
Chella David, Donald Shreffler, Jeffrey Frelinger (1973)
New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.Proceedings of the National Academy of Sciences of the United States of America, 70 9
Van Jj, Koch Ct, Van Jp, A. vanLeeuwen, van Jg, E. Frederiks, Schippers Hm, Hendriks Gf, van Gj (1973)
Graft survival in unrelated donor--recipient pairs matched for MLC and HL-A.Transplantation proceedings, 5 1
M. Plaut, L. Lichtenstein, C. Henney (1973)
Studies on the mechanism of lymphocyte-mediated cytolysis. 3. The role of microfilaments and microtubules.Journal of immunology, 110 3
R. Hodes, E. Svedmyr (1970)
SPECIFIC CYTOTOXICITY OF H-2-INCOMPATIBLE MOUSE LYMPHOCYTES FOLLOWING MIXED CULTURE IN VITROTransplantation, 9
J. Kennedy, J. Ekpaha-Mensah (1973)
Genetics of Stimulation of in Vitro Hemolytic Plaque-Forming Cell Responses by Irradiated Allogeneic Spleen CellsThe Journal of Immunology
H. Wekerle, P. Lonai, M. Feldman (1972)
Fractionation of antigen reactive cells on a cellular immunoadsorbent: factors determining recognition of antigens by T-lymphocytes.Proceedings of the National Academy of Sciences of the United States of America, 69 6
J. Klein, J. Park (1973)
GRAFT-VERSUS-HOST REACTION ACROSS DIFFERENT REGIONS OF THE H-2 COMPLEX OF THE MOUSEThe Journal of Experimental Medicine, 137
E. Yunis, Amos Db (1971)
Three closely linked genetic systems relevant to transplantation.Proceedings of the National Academy of Sciences of the United States of America, 68 12
S. Cohen (1971)
Histocompatibility Testing 1970Immunology, 21
Trans-43 van Rood
Pekka H�yry, V. Defendi (1970)
Mixed Lymphocyte Cultures Produce Effector Cells: Model in vitro for Allograft RejectionScience, 168
V. Hauptfeld, D. Klein, J. Klein (1973)
Serological Identification of an Ir-Region ProductScience, 181
H. Wagner, M. Röllinghoff (1973)
IN VITRO INDUCTION OF TUMOR-SPECIFIC IMMUNITYThe Journal of Experimental Medicine, 138
P. Golstein, H. Wigzell, H. Blomgren, E. Svedmyr (1972)
Autonomy of thymus‐processed lymphocytes (T cells) for their education into cytotoxic cellsEuropean Journal of Immunology, 2
B. Alter, D. Schendel, M. Bach, F. Bach, J. Klein, J. Stimpfling (1973)
CELL-MEDIATED LYMPHOLYSISThe Journal of Experimental Medicine, 137
E. Yunis, H. Seigler, R. Simmons, D. Amos (1973)
HL‐A TYPING, MIXED LEUKOCYTE REACTIVITY, AND SKIN GRAFT SURVIVAL IN A FAMILY WITH A RECOMBINANT AT THE HL‐1 CHROMOSOMAL REGION (MAJOR TRANSPLANTATION REGION)1Transplantation, 15
H. Wagner, M. Feldmann (1972)
Cell-mediated immune response in vitro: I. A new in vitro system for the generation of cell-mediated cytotoxic activityCellular Immunology, 3
M. Mandel, R. Asofsky (1969)
THE EFFECTS OF HETEROLOGOUS ANTI-THYMOCYTE SERA IN MICEThe Journal of Experimental Medicine, 129
The requirements for killer cell production in the course of a mixed leukocyte reaction and the specificity of target cell (PHA‐blasts) lysis in the mouse were investigated using inbred strains carrying intra‐H‐2 recombinant chromosomes. Strong lytic activity was generated in all, and only those, responder‐stimulator combinations which differed at either the H‐2D or the H‐2K, or both regions, even if the MLR incompatibility between responder and stimulator was very weak. Killing activity was specific and directed against determinants controlled by genes in the H‐2K and H‐2D regions. The slope of the killer dose‐response curves is the same for either type of specificity. Quantitative comparison of the lytic activity of a given killer cell population on different targets demonstrated a dose effect of the number of specificities recognized. No significant killing against the Ir or the Ss‐Slp regions of the H‐2 complex could be detected. AntiH2 sera, if directed against the killer cells, do not inhibit their activity, while they can block killing, if directed against the target. This inhibition is specific in that a serum that blocks killing against the H‐2K specificity of a given target does not inhibit the lytic activity directed against the H‐2D determinants on the same target.
European Journal of Immunology – Wiley
Published: May 1, 1974
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