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- Publisher
- Annual Reviews
- Copyright
- Copyright © 2007 by Annual Reviews. All rights reserved
- ISSN
- 0066-4219
- eISSN
- 1545-326X
- DOI
- 10.1146/annurev.med.58.061705.145053
- pmid
- 16886905
- Publisher site
- See Article on Publisher Site
Abstract
Abstract The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed.
Journal
Annual Review of Medicine – Annual Reviews
Published: Feb 18, 2007