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Evolution, Population Structure, and Phylogeography of Genetically Monomorphic Bacterial Pathogens

Evolution, Population Structure, and Phylogeography of Genetically Monomorphic Bacterial Pathogens Genetically monomorphic bacteria contain so little sequence diversity that sequencing a few gene fragments yields little or no information. As a result, our understanding of their evolutionary patterns presents greater technical challenges than exist for genetically diverse microbes. These challenges are now being met by analyses at the genomic level for diverse types of genetic variation, the most promising of which are single nucleotide polymorphisms. Many of the most virulent bacterial pathogens are genetically monomorphic, and understanding their evolutionary and phylogeographic patterns will help our understanding of the effects of infectious disease on human history. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Evolution, Population Structure, and Phylogeography of Genetically Monomorphic Bacterial Pathogens

Annual Review of Microbiology , Volume 62 – Oct 13, 2008

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Publisher
Annual Reviews
Copyright
Copyright © 2008 by Annual Reviews. All rights reserved
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.micro.62.081307.162832
pmid
18785837
Publisher site
See Article on Publisher Site

Abstract

Genetically monomorphic bacteria contain so little sequence diversity that sequencing a few gene fragments yields little or no information. As a result, our understanding of their evolutionary patterns presents greater technical challenges than exist for genetically diverse microbes. These challenges are now being met by analyses at the genomic level for diverse types of genetic variation, the most promising of which are single nucleotide polymorphisms. Many of the most virulent bacterial pathogens are genetically monomorphic, and understanding their evolutionary and phylogeographic patterns will help our understanding of the effects of infectious disease on human history.

Journal

Annual Review of MicrobiologyAnnual Reviews

Published: Oct 13, 2008

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