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Cyclin-dependent kinases: a family portrait

Cyclin-dependent kinases: a family portrait CORRESPONDENCE 1,10 2 3 4 5 6 Marcos Malumbres , Edward Harlow , Tim Hunt , Tony Hunter , Jill M. Lahti , Gerard Manning , 7 8 9 David O. Morgan , Li-Huei Tsai and Debra J. Wolgemuth To the Editor, tion with some cyclin-like regulatory subunit. (CrkRS) and Ched (Cdc2L5), were recently Cyclin-dependent kinases (CDKs) are protein Known family members were then renamed renamed CDK12 and CDK13, as they were kinases involved in critical cellular processes, CDK1–6, and further members (CDK7– reported to interact with cyclin L1 and cyclin such as cell cycle or transcription, whose activ- CDK10) were cloned and characterized in the L2 (refs 3, 4). ity requires association with specific cyclin sub- following years . CDK11 has been used to refer Additional members of the family, such units. Based on sequence similarity, the human to the protein encoded by three different human as PCTAIRE and PFTAIRE proteins, CCRK genome contains 21 genes encoding CDKs and loci (CDC2L1, CDC2L2 and CDC2L6) in differ- and CDC2L6, although being very similar to five additional genes encoding a more distant ent publications. CDC2L1 and CDC2L2 are two other CDKs in their primary sequence (Fig. 1) group of proteins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Cell Biology Springer Journals

Cyclin-dependent kinases: a family portrait

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References (12)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Nature Publishing Group
Subject
Life Sciences; Life Sciences, general; Cell Biology; Cancer Research; Developmental Biology; Stem Cells
ISSN
1465-7392
eISSN
1476-4679
DOI
10.1038/ncb1109-1275
Publisher site
See Article on Publisher Site

Abstract

CORRESPONDENCE 1,10 2 3 4 5 6 Marcos Malumbres , Edward Harlow , Tim Hunt , Tony Hunter , Jill M. Lahti , Gerard Manning , 7 8 9 David O. Morgan , Li-Huei Tsai and Debra J. Wolgemuth To the Editor, tion with some cyclin-like regulatory subunit. (CrkRS) and Ched (Cdc2L5), were recently Cyclin-dependent kinases (CDKs) are protein Known family members were then renamed renamed CDK12 and CDK13, as they were kinases involved in critical cellular processes, CDK1–6, and further members (CDK7– reported to interact with cyclin L1 and cyclin such as cell cycle or transcription, whose activ- CDK10) were cloned and characterized in the L2 (refs 3, 4). ity requires association with specific cyclin sub- following years . CDK11 has been used to refer Additional members of the family, such units. Based on sequence similarity, the human to the protein encoded by three different human as PCTAIRE and PFTAIRE proteins, CCRK genome contains 21 genes encoding CDKs and loci (CDC2L1, CDC2L2 and CDC2L6) in differ- and CDC2L6, although being very similar to five additional genes encoding a more distant ent publications. CDC2L1 and CDC2L2 are two other CDKs in their primary sequence (Fig. 1) group of proteins

Journal

Nature Cell Biology – Springer Journals

Published: Nov 1, 2009

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