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The role of randomization in clinical trials

The role of randomization in clinical trials Random assignment of treatments is an essential feature of experimental design in general and clinical trials in particular. It provides broad comparability of treatment groups and validates the use of statistical methods for the analysis of results. Various devices are available for improving the balance of prognostic factors across treatment groups. Several recentt initiatives to diminish the role of randomization are seen as being potentially misleading. Randomization is entirely compatible with medical ethics in circumstances when the treatment of choice is not clearly identified. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Statistics in Medicine Wiley

The role of randomization in clinical trials

Statistics in Medicine , Volume 1 (4) – Jan 1, 1982

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References (31)

Publisher
Wiley
Copyright
Copyright © 1982 John Wiley & Sons, Ltd.
ISSN
0277-6715
eISSN
1097-0258
DOI
10.1002/sim.4780010412
Publisher site
See Article on Publisher Site

Abstract

Random assignment of treatments is an essential feature of experimental design in general and clinical trials in particular. It provides broad comparability of treatment groups and validates the use of statistical methods for the analysis of results. Various devices are available for improving the balance of prognostic factors across treatment groups. Several recentt initiatives to diminish the role of randomization are seen as being potentially misleading. Randomization is entirely compatible with medical ethics in circumstances when the treatment of choice is not clearly identified.

Journal

Statistics in MedicineWiley

Published: Jan 1, 1982

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