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J. Blendy, Klaus Kaestner, Wolfgang Schmid, Peter Gass, Günther Schütz (1996)
Targeting of the CREB gene leads to up‐regulation of a novel CREB mRNA isoform.The EMBO Journal, 15
P. Gass, D. Wolfer, D. Balschun, D. Rudolph, U. Frey, H. Lipp, G. Schütz (1998)
Deficits in memory tasks of mice with CREB mutations depend on gene dosage.Learning & memory, 5 4-5
Dagerlind (1992)
Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistryHistochem., 98
Stephen Maren (1996)
Synaptic transmission and plasticity in the amygdala. An emerging physiology of fear conditioning circuits.Molecular neurobiology, 13 1
J. Wagner, B. Alger (1995)
GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus, 15
M. Mayford, M. Bach, Yan-You Huang, Lei Wang, R. Hawkins, E. Kandel (1996)
Control of Memory Formation Through Regulated Expression of a CaMKII TransgeneScience, 274
P. Ornstein (1989)
An enantioselective synthesis of D-(-)-2-amino-5-phosphonopentanoic acidJournal of Organic Chemistry, 54
S. Schreiber, Stephen Maren, G. Tocco, T. Shors, R. Thompson (1991)
A negative correlation between the induction of long-term potentiation and activation of immediate early genes.Brain research. Molecular brain research, 11 1
M. Rogan, U. Stäubli, Joseph LeDoux (1997)
Fear conditioning induces associative long-term potentiation in the amygdalaNature, 390
AMPA, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate
Joseph LeDoux (1995)
Emotion: clues from the brain.Annual review of psychology, 46
C. Norris, S. Halpain, T. Foster (1998)
Reversal of Age-Related Alterations in Synaptic Plasticity by Blockade of L-Type Ca2+ ChannelsThe Journal of Neuroscience, 18
M. Loriaux, R. Brennan, R. Goodman (1994)
Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation.The Journal of biological chemistry, 269 46
cAMP response element; CREB, cAMP response element-binding protein; CREM, cAMP response element modulator
K. Barton, N. Muthusamy, M. Chanyangam, C. Fischer, C. Clendenin, J. Leiden (1996)
Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREBNature, 379
R. Lamprecht, S. Hazvi, Y. Dudai (1997)
cAMP Response Element-Binding Protein in the Amygdala Is Required for Long- but not Short-Term Conditioned Taste Aversion MemoryThe Journal of Neuroscience, 17
T. Meyer, G. Waeber, J. Lin, W. Beckmann, J. Habener (1993)
The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription.Endocrinology, 132 2
S. Killcross, T. Robbins, B. Everitt (1997)
Different types of fear-conditioned behaviour mediated by separate nuclei within amygdalaNature, 388
Inhibitory synaptic transmission modulates the induction of long-term depression in CA1 region of hippocampus
R. Fentzke, C. Korcarz, R. Lang, Hua-Heng Lin, J. Leiden (1998)
Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart.The Journal of clinical investigation, 101 11
R. Bourtchuladze, B. Frenguelli, J. Blendy, Diana Cioffi, G. Schutz, Alcino Silva (1994)
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding proteinCell, 79
Stephen Maren, M. Fanselow (1996)
The Amygdala and Fear Conditioning: Has the Nut Been Cracked?Neuron, 16
ATF-1, activating transcription factor-1
G. Gonzalez, M. Montminy (1989)
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Cell, 59
M. Bear, W. Abraham (1996)
Long-term depression in hippocampus.Annual review of neuroscience, 19
T. Sunyer, N. Sahyoun (1990)
Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene.Proceedings of the National Academy of Sciences of the United States of America, 87 1
He Li, S. Weiss, D. Chuang, R. Post, M. Rogawski (1998)
Bidirectional Synaptic Plasticity in the Rat Basolateral Amygdala: Characterization of an Activity-Dependent Switch Sensitive to the Presynaptic Metabotropic Glutamate Receptor Antagonist 2S-α-Ethylglutamic AcidThe Journal of Neuroscience, 18
A. Pitkänen, V. Savander, Joseph LeDoux (1997)
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdalaTrends in Neurosciences, 20
Yasumasa Watanabe, Y. Ikegaya, H. Saito, K. Abe (1995)
Roles of GABAA, NMDA and muscarinic receptors in induction of long-term potentiation in the medial and lateral amygdala in vitroNeuroscience Research, 21
M. Davis, C. Shi (2000)
The amygdalaCurrent Biology, 10
J. Kogan, P. Frankland, J. Blendy, J. Coblentz, Z. Marowitz, G. Schütz, Alcino Silva (1997)
Spaced training induces normal long-term memory in CREB mutant miceCurrent Biology, 7
T. Hatfield, Jung-Soo Han, M. Conley, M. Gallagher, P. Holland (1996)
Neurotoxic Lesions of Basolateral, But Not Central, Amygdala Interfere with Pavlovian Second-Order Conditioning and Reinforcer Devaluation EffectsThe Journal of Neuroscience, 16
Su-Jane Wang, P. Gean (1999)
Long-Term Depression of Excitatory Synaptic Transmission in the Rat AmygdalaThe Journal of Neuroscience, 19
Joseph LeDoux (1996)
Emotional networks and motor control: a fearful view.Progress in brain research, 107
D. Rainnie, E. Asprodini, P. Shinnick‐Gallagher (1991)
Excitatory transmission in the basolateral amygdala.Journal of neurophysiology, 66 3
F. Crestani, M. Lorez, K. Baer, C. Essrich, D. Benke, J. Laurent, C. Belzung, J. Fritschy, B. Lüscher, H. Mohler (1999)
Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cuesNature Neuroscience, 2
M. McEchron, H. Bouwmeester, Wilbur Tseng, C. Weiss, J. Disterhoft (1999)
Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the ratHippocampus, 8
J. Eccles (1980)
The emotional brain.Bulletin et memoires de l'Academie royale de medecine de Belgique, 135 11
PTP, post-tetanic potentiation
M. Davis, D. Rainnie, M. Cassell (1994)
Neurotransmission in the rat amygdala related to fear and anxietyTrends in Neurosciences, 17
Yue Wang, M. Rowan, R. Anwyl (1997)
Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores.Journal of neurophysiology, 77 2
M. Rogan, Joseph LeDoux (1996)
Emotion: Systems, Cells, Synaptic PlasticityCell, 85
Yan-You Huang, E. Kandel (1998)
Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral AmygdalaNeuron, 21
LTD, long-term depression
E. Coven, Yan Ni, K. Widnell, Jingshan Chen, W. Walker, J. Habener, Eric Nestler (1998)
Cell Type‐Specific Regulation of CREB Gene Expression: Mutational Analysis of CREB Promoter ActivityJournal of Neurochemistry, 71
Stephen Maren, M. Fanselow (1995)
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo, 15
M. Mayford, Jian Wang, E. Kandel, T. O’Dell (1995)
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTPCell, 81
T. Bliss, G. Collingridge (1993)
A synaptic model of memory: long-term potentiation in the hippocampusNature, 361
LFS, low-frequency stimulation
D. Rudolph, A. Tafuri, P. Gass, G. Hämmerling, B. Arnold, G. Schütz (1998)
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein.Proceedings of the National Academy of Sciences of the United States of America, 95 8
Ca 2+ /calmodulin-dependent kinase IIa
LTP, long-term potentiation; NBQX, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]-quinoxaline-7-sulphonamide disodium
Choi (1991)
A generic intron increases gene expression in transgenic miceMol. Cell. Biol., 11
M. Bouton, R. Bolles (1980)
Conditioned fear assessed by freezing and by the suppression of three different baselinesAnimal Learning & Behavior, 8
J. Gewirtz, Michael Davis (1997)
Second-order fear conditioning prevented by blocking NMDA receptors in amygdalaNature, 388
R. Struthers, Wylie Vale, C. Arias, P. Sawchenko, M. Montminy (1991)
Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutantNature, 350
Alcino Silva, J. Kogan, P. Frankland, S. Kida (1998)
CREB and memory.Annual review of neuroscience, 21
J. Krettek, J. Price (1978)
A description of the amygdaloid complex in the rat and cat with observations on intra‐amygdaloid axonal connectionsJournal of Comparative Neurology, 178
Swanson Swanson, Petrovich Petrovich (1998)
What is the amygdala?Trends Neurosci., 21
J. Radulovic, J. Kammermeier, J. Spiess (1998)
Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioningBehavioural Brain Research, 95
P. Chapman, L. Bellavance (1992)
Induction of long‐term potentiation in the basolateral amygdala does not depend on NMDA receptor activationSynapse, 11
STP, short-term potentiation; UCS, unconditioned stimulus
T. Choi, M. Huang, C. Gorman, R. Jaenisch (1991)
A generic intron increases gene expression in transgenic miceMolecular and Cellular Biology, 11
Electrophysiological and behavioural experiments were performed in transgenic mice expressing a dominant‐negative form of cAMP response element‐binding protein (CREBA133) in the limbic system. In control littermate in vitro slice preparation, tetanizing the lateral amygdala–basolateral amygdala (BLA) pathway with a single train (100 Hz for 1 s) produced short‐term potentiation (STP) in the BLA. Five trains (10‐s interstimulus interval) induced long‐term potentiation (LTP), which was completely blocked by the N‐methyl‐ d‐aspartate (NMDA) receptor antagonist d(–)‐2‐amino‐5‐phosphonopentanoic acid (AP5; 50 μm). When GABAergic (γ‐aminobutyric acid) inhibition was blocked by picrotoxin (10 μm), LTP became more pronounced. Low‐frequency stimulation (1 Hz for 15 min) induced either long‐term depression (LTD) or depotentiation. LTD remained unaffected by AP5 (50 μm) or by the L‐ and T‐type Ca2+‐channel blockers nifedipine (20 μm) and Ni2+ (50 μm), but was prevented by picrotoxin (10 μm), indicating a GABAergic link in the expression of LTD in the BLA. When conditioned fear was tested, a mild impairment was seen in one of three transgenic lines only. Although high levels of mRNA encoding CREBA133 lead to downregulation of endogenous CREB, expression of LTP and depotentiation were unaltered in BLA of these transgenic animals. These results could suggest that residual CREB activity was still present or that CREB per se is dispensable. Alternatively, other CREB‐like proteins were able to compensate for impaired CREB function.
European Journal of Neuroscience – Wiley
Published: Jul 1, 2000
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