Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Petersen, L. Jensen, T. Honoré, C. Braestrup (1983)
Differential pharmacological effects of benzodiazepine receptor inverse agonists.Advances in biochemical psychopharmacology, 38
(1983)
Where in the brain do benzodiazepines act? In: Trimble MR (ed) Benzodiazepincs divided
J. Sepinwall, L. Cook (1978)
Behavioral Pharmacology of Antianxiety Drugs
S. Quintero, S. Henney, P. Lawson, J. Mellanby, J. Gray (2004)
The effects of compounds related to γ-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: Punished barpressingPsychopharmacology, 85
S. File, R. Lister, D. Nutt (1982)
The anxiogenic action of benzodiazepine antagonistsNeuropharmacology, 21
P. Bovier, C. Broekkamp, K. Lloyd (1982)
Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey regionBrain Research, 248
H. Hodges, S. Baum, P. Taylor, S. Green (2004)
Behavioural and pharmacological dissociation of chlordiazepoxide effects on discrimination and punished respondingPsychopharmacology, 89
E. Petersen, L. Jensen (1984)
Proconflict effect of benzodiazepine receptor inverse agonists and other inhibitors of GABA function.European journal of pharmacology, 103 1-2
J. Gray (1985)
The neuropsychology of anxiety.Issues in mental health nursing, 7 1-4
C. Dourish, P. Hutson, G. Curzon (2004)
Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the ratPsychopharmacology, 86
(1984)
Anticonflict effects of 5-HT antagonists by intraamygdaloid injection
L. Jensen, E. Petersen, C. Braestrup, T. Honoré, W. Kehr, D. Stephens, H. Schneider, D. Seidelmann, R. Schmiechen (2004)
Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonistPsychopharmacology, 83
C. Buckland, J. Mellanby, J. Gray (2004)
The effects of compounds related to γ-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: Extinction and successive discriminationPsychopharmacology, 88
E. Bonetti, L. Pieri, R. Cumin, R. Schaffner, M. Pieri, E. Gamzu, R. Müller, W. Haefely (2004)
Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effectsPsychopharmacology, 78
J. Engel, S. Hjorth, K. Svensson, A. Carlsson, S. Liljequist (1984)
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).European journal of pharmacology, 105 3-4
M. Brandão, J. Aguiar, F. Graeff (1982)
GABA mediation of the anti-aversive action of minor tranquilizersPharmacology Biochemistry and Behavior, 16
W. Hunkeler, H. Möhler, L. Pieri, P. Polc, E. Bonetti, R. Cumin, R. Schaffner, W. Haefely (1981)
Selective antagonists of benzodiazepinesNature, 290
J. Feldon,, T. Lerner, D. Levin, M. Myslobodsky (1983)
A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788Pharmacology Biochemistry and Behavior, 19
(1984)
Anti-conflict effect of the putative serotonin agonist
S. Green, H. Hodges (1986)
Differential effects of dorsal raphe lesions and intraraphe GABA and benzodiazepines on conflict behavior in rats.Behavioral and neural biology, 46 1
S. Pellow, S. File (2004)
Multiple sites of action for anxiogenic drugs: Behavioural, electrophysiological and biochemical correlationsPsychopharmacology, 83
M. Schütz, J. Aguiar, F. Graeff (2004)
Anti-aversive role of serotonin in the dorsal periaqueductal grey matterPsychopharmacology, 85
M. Thiébot, M. Hamon, P. Soubrié (1982)
Attenuation of induced-anxiety in rats by chlordiazepoxide: Role of raphe dorsalis benzodiazepine binding sites and serotoninergic neuronsNeuroscience, 7
N. Tye, S. Iversen, A. Green (1979)
The effects of benzodiazepines and serotonergic manipulations on punished respondingNeuropharmacology, 18
L. Pellegrino, A. Cushman (1967)
stereotaxic atlas of the rat brain
P. Polc, E. Bonetti, R. Schaffner, W. Haefely (1982)
A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, β-carbolines, and phenobarbitoneNaunyn-Schmiedeberg's Archives of Pharmacology, 321
F. Graeff, J. Rawlins (1980)
Dorsal periaqueductal gray punishment, septal lesions and the mode of action of minor tranquilizersPharmacology Biochemistry and Behavior, 12
Ro
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788
M. Thiébot, P. Soubrié, M. Hamon, P. Simon (2004)
Evidence against the involvement of serotonergic neurons in the anti-punishment activity of diazepam in the ratPsychopharmacology, 82
J. Scheel‐Krüger, E. Petersen (1982)
Anticonflict effect of the benzodiazepines mediated by a GABAergic mechanism in the amygdala.European journal of pharmacology, 82 1-2
M. Thiébot, A. Jobert, P. Soubrié (1980)
Chlordiazepoxide and GABA injected into raphé dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive componentNeuropharmacology, 19
H. Gozlan, S. Mestikawy, L. Pichat, J. Glowinski, M. Hamon (1983)
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PATNature, 305
H. Hodges, S. Green (1984)
Evidence for the involvement of brain GABA and serotonin systems in the anticonflict effects of chlordiazepoxide in rats.Behavioral and neural biology, 40 2
Stephen Thomas, M. Lewis, S. Iversen (1985)
Correlation of [3H]diazepam binding density with anxiolytic locus in the amygdaloid complex of the ratBrain Research, 342
D. Middlemiss (1984)
8-Hydroxy-2-(di-n-propylamino) tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H] 5-HT recognition siteNaunyn-Schmiedeberg's Archives of Pharmacology, 327
S. File, S. Pellow (2004)
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788Psychopharmacology, 88
(1973)
Antianxiety action of benzodiazepines: decreases in activity of serotonin neurons in punishment systems
R. Kirk (1970)
Experimental Design: Procedures for the Behavioral Sciences
213 92 92 4 4 H. Hodges S. Green B. Glenn Department of Psychology Institute of Psychiatry De Crespigny Park SE5 8AF London UK Department of Psychology Birkbeck College Malet Street WC1E 7HX London UK Abstract Interactions between the benzodiazepines (BZs) chlordiazepoxide (CDP) and midazolam (MDZ), the BZ antagonist R0 15-1788, the inverse BZ receptor agonists CGS 8216 and FG 7142, γ-aminobutyrate (GABA), serotonin (5-HT), the 5-HT 2 antagonist methysergide and the putative 5-HT agonist 8-hydroxy-2-(di- n -propylamino) tetralin (8-OH-DPAT) were investigated using peripheral and intra-amygdaloid treatments. A multiple schedule consisting of rewarded, nonrewarded (Time out: TO) and conflict periods was used to compare in parallel effects on successive discrimination between rewarded and nonrewarded periods and punished responding. The three components were presented in both a fixed order (Experiment 1) and a random order (Experiments 2 and 3). Intra-amygdaloid treatments with GABA and the BZs selectively increased rates of punished responding. CDP given systemically, on the other hand, increased both TO and conflict rates, suggesting an additional impairment of discrimination, which was more marked in the random than the fixed order condition. R0 15-1788, CGS 8216 and FG 7142 given by both routes counteracted the anti-conflict effects of CDP given centrally or systemically. However increases in TO rates induced by IP CDP were antagonized only by IP treatments with these compounds. The two inverse agonists, but not R0 15-1788, also counteracted increases in punished responding which were found after intra-amygdaloid GABA infusions. In Experiments 2 and 3 where baseline rates of pressing in Conflict periods were sufficiently high to detect decreases, CGS 8216 and FG 7142 reduced responding below control level, suggesting a specific anxiogenic activity. Evidence for effects of R0 15-1788 by itself was inconclusive. 5-HT injected into the amygdala also reduced punished responding below control level, whereas methysergide increased it with both central and peripheral treatment. Effects of 8-OH-DPAT varied according to route of administration. With IP treatment Conflict rates were increased, but after amygdaloid infusion both TO and Conflict rates were marginally reduced below control level, with a more consistent depression of punished responding. These results provide evidence that effects of BZs on punished responding are mediated by a GABAergic system which includes the lateral/basolateral amygdala, but which does not participate in BZ-induced disruption of discrimination. They also indicate that the antagonistic effects of CGS 8216 and FG 7142 involve a decrease in GABA transmission, and that these compounds may also be anxiogenic. Finally, the results suggest that 5-HT utilizes the same system for regulating resistance to punishment, but plays no significant part in reward-nonreward successive discrimination, which is impaired after systemic BZs.
Psychopharmacology – Springer Journals
Published: Aug 1, 1987
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.