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Differential effects of dopamine receptor antagonists on the sexual behavior of male rats

Differential effects of dopamine receptor antagonists on the sexual behavior of male rats 213 98 98 3 3 James G. Pfaus Anthony G. Phillips Department of Psychology The University of British Columbia 2136 West Mall V6T 1Y7 Vancouver B.C. Canada Abstract In the present experiments, the dose-response effects of the dopamine (DA) receptor antagonists haloperidol, pimozide, clozapine, sulpiride, and metoclopramide, were assessed on patterns of copulatory behavior in intact, sexually active male rats with a high level of sexual experience and performance. The typical neuroleptics haloperidol (0.01–0.5 mg/kg) and pimozide (0.1–5.0 mg/kg) dose-dependently delayed the initiation of copulation and reduced the number of intromissions that preceded ejaculation. The atypical neuroletpics clozapine (0.1–5.0 mg/kg), and sulpiride (0.1–5.0 mg/kg) dose-dependently delayed the initiation of copulation but had no effect on copulatory behavior once it was initiated. In contrast, metoclopramide dose-dependently reduced the number of intromissions that preceded ejaculation but had no effect on the ability of rats to initiate copulation. These experiments suggest that aspects of copulatory behavior in male rats are affected differently by DA antagonists depending upon their site of action in the brain. Blockade of mesolimbic DA receptors by typical and atypical neuroleptics may delay the initiation of copulation, whereas blockade of mesostriatal DA receptors by typical neuroleptics and metoclopramide may decrease the ejaculation threshold. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Differential effects of dopamine receptor antagonists on the sexual behavior of male rats

Psychopharmacology , Volume 98 (3) – Jul 1, 1989

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References (38)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00451688
Publisher site
See Article on Publisher Site

Abstract

213 98 98 3 3 James G. Pfaus Anthony G. Phillips Department of Psychology The University of British Columbia 2136 West Mall V6T 1Y7 Vancouver B.C. Canada Abstract In the present experiments, the dose-response effects of the dopamine (DA) receptor antagonists haloperidol, pimozide, clozapine, sulpiride, and metoclopramide, were assessed on patterns of copulatory behavior in intact, sexually active male rats with a high level of sexual experience and performance. The typical neuroleptics haloperidol (0.01–0.5 mg/kg) and pimozide (0.1–5.0 mg/kg) dose-dependently delayed the initiation of copulation and reduced the number of intromissions that preceded ejaculation. The atypical neuroletpics clozapine (0.1–5.0 mg/kg), and sulpiride (0.1–5.0 mg/kg) dose-dependently delayed the initiation of copulation but had no effect on copulatory behavior once it was initiated. In contrast, metoclopramide dose-dependently reduced the number of intromissions that preceded ejaculation but had no effect on the ability of rats to initiate copulation. These experiments suggest that aspects of copulatory behavior in male rats are affected differently by DA antagonists depending upon their site of action in the brain. Blockade of mesolimbic DA receptors by typical and atypical neuroleptics may delay the initiation of copulation, whereas blockade of mesostriatal DA receptors by typical neuroleptics and metoclopramide may decrease the ejaculation threshold.

Journal

PsychopharmacologySpringer Journals

Published: Jul 1, 1989

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