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A growing number of medical research teams have begun to explore the experimental advantages of using a genetic animal model, the nematode worm Caenorhabditis elegans , with a view to enhancing our understanding of genes underlying human congenital disorders. In this study, we have compared sequences of positionally cloned human disease genes with the C.elegans database of predicted genes. Drawing on examples from spinal muscular atrophy, polycystic kidney disease, muscular dystrophy and Alzheimer’s disease, we illustrate how data from C.elegans can yield new insights into the function and interactions of human disease genes. Received 28 January 2000; Accepted 7 February 2000. « Previous | Next Article » Table of Contents This Article Hum. Mol. Genet. (2000) 9 (6): 869-877. doi: 10.1093/hmg/9.6.869 This article appears in: Review Issue 2000 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Report Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Culetto, E. Articles by Sattelle, D. B. Search for related content PubMed PubMed citation Articles by Culetto, E. Articles by Sattelle, D. B. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? 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Human Molecular Genetics – Oxford University Press
Published: Apr 1, 2000
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