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DIFFERENTIAL EFFECTS OF PENTOBARBITAL AND COCAINE ON PUNISHED AND NONPUNISHED RESPONDING

DIFFERENTIAL EFFECTS OF PENTOBARBITAL AND COCAINE ON PUNISHED AND NONPUNISHED RESPONDING Similar rates of punished and nonpunished responding, maintained with equated rates of reinforcement, were established in pairs of rats. One subject of each pair was exposed to a random‐ratio schedule of food presentation. The interreinforcement intervals for this subject comprised the intervals of a random‐interval schedule of reinforcement for the other (yoked) rat. The random‐ratio schedule maintained rates of responding higher than those maintained by the same rate of reinforcement schedule according to the yoked random‐interval contingency. A random‐ratio schedule of electric foot shock added to the random‐ratio schedule of food presentation suppressed rates of responding such that similar rates of responding were observed in rats of both groups. Pentobarbital (3.0 to 17.0 mg/kg) increased punished responding at doses that had little effect on or decreased nonpunished responding, whereas cocaine (5.6 to 30 mg/kg) increased nonpunished responding at doses that decreased or did not alter punished responding. Qualitatively different effects of pharmacological agents on punished and nonpunished responding can be obtained using procedures that generate similar rates and temporal patterns of punished and nonpunished responding. The effects of pentobarbital and cocaine on responding can be determined by factors other than simply the baseline rate of responding. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the Experimental Analysis of Behavior Wiley

DIFFERENTIAL EFFECTS OF PENTOBARBITAL AND COCAINE ON PUNISHED AND NONPUNISHED RESPONDING

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References (27)

Publisher
Wiley
Copyright
1989 Society for the Experimental Analysis of Behavior
ISSN
0022-5002
eISSN
1938-3711
DOI
10.1901/jeab.1989.51-173
pmid
2708936
Publisher site
See Article on Publisher Site

Abstract

Similar rates of punished and nonpunished responding, maintained with equated rates of reinforcement, were established in pairs of rats. One subject of each pair was exposed to a random‐ratio schedule of food presentation. The interreinforcement intervals for this subject comprised the intervals of a random‐interval schedule of reinforcement for the other (yoked) rat. The random‐ratio schedule maintained rates of responding higher than those maintained by the same rate of reinforcement schedule according to the yoked random‐interval contingency. A random‐ratio schedule of electric foot shock added to the random‐ratio schedule of food presentation suppressed rates of responding such that similar rates of responding were observed in rats of both groups. Pentobarbital (3.0 to 17.0 mg/kg) increased punished responding at doses that had little effect on or decreased nonpunished responding, whereas cocaine (5.6 to 30 mg/kg) increased nonpunished responding at doses that decreased or did not alter punished responding. Qualitatively different effects of pharmacological agents on punished and nonpunished responding can be obtained using procedures that generate similar rates and temporal patterns of punished and nonpunished responding. The effects of pentobarbital and cocaine on responding can be determined by factors other than simply the baseline rate of responding.

Journal

Journal of the Experimental Analysis of BehaviorWiley

Published: Mar 1, 1989

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