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Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation

Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic... rodents in response to experimental models of inflammation (13, 14, 16,22). Prostaglandins are thought to mediate the actions of many cytokines. Perhaps the best studied and documented is prostaglandin Ez (PGEB), which is a key mediator of fever (29). Studies of the involvement of PGE2 in the generation of anorexia and cachexia have thus far resulted in inconclusive data. For example, peripheral and central administration of prostaglandins produced anorexia in the rat (25). However, when cyclooxygenase inhibitors are used to test the prostaglandin dependence of the anorexigenic and cachectic effects of inflammatory agents, data suggest that anorexia and weight loss may (27, 37) or may not (30) be mediated by PGEz. Because the endogenous metabolism of prostaglandins and other eicosanoids can be modulated by dietary supplementation with polyunsaturated such as those present in fish oil (24), during infection/inflammation constitutes a potential site of interaction for these . Eicosapentaenoic [20:5 (>] and docosahexaenoic [22:6 (>] are abundant in marine oils and, when present in the diet, are preferentially incorporated into membrane phospholipids, reducing the content of arachidonic acid (24). Arachidonic acid is a member of the n-6 family and a precursor of the two series of prostaglandins. There is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation

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Publisher
The American Physiological Society
Copyright
Copyright © 1997 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

rodents in response to experimental models of inflammation (13, 14, 16,22). Prostaglandins are thought to mediate the actions of many cytokines. Perhaps the best studied and documented is prostaglandin Ez (PGEB), which is a key mediator of fever (29). Studies of the involvement of PGE2 in the generation of anorexia and cachexia have thus far resulted in inconclusive data. For example, peripheral and central administration of prostaglandins produced anorexia in the rat (25). However, when cyclooxygenase inhibitors are used to test the prostaglandin dependence of the anorexigenic and cachectic effects of inflammatory agents, data suggest that anorexia and weight loss may (27, 37) or may not (30) be mediated by PGEz. Because the endogenous metabolism of prostaglandins and other eicosanoids can be modulated by dietary supplementation with polyunsaturated such as those present in fish oil (24), during infection/inflammation constitutes a potential site of interaction for these . Eicosapentaenoic [20:5 (>] and docosahexaenoic [22:6 (>] are abundant in marine oils and, when present in the diet, are preferentially incorporated into membrane phospholipids, reducing the content of arachidonic acid (24). Arachidonic acid is a member of the n-6 family and a precursor of the two series of prostaglandins. There is

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Apr 1, 1997

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