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J. Klein, M. Fasshauer, Moriko Ito, B. Lowell, M. Benito, C. Kahn (1999)
β3-Adrenergic Stimulation Differentially Inhibits Insulin Signaling and Decreases Insulin-induced Glucose Uptake in Brown Adipocytes*The Journal of Biological Chemistry, 274
N. Kubota, Y. Terauchi, T. Yamauchi, Tetsuya Kubota, M. Moroi, J. Matsui, K. Eto, Tokuyuki Yamashita, J. Kamon, H. Satoh, Wataru Yano, P. Froguel, R. Nagai, S. Kimura, T. Kadowaki, T. Noda (2002)
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation*The Journal of Biological Chemistry, 277
Kee-Hong Kim, Kichoon Lee, Y. Moon, H. Sul (2001)
A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation*The Journal of Biological Chemistry, 276
C. Kallen, M. Lazar (1996)
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.Proceedings of the National Academy of Sciences of the United States of America, 93 12
Juerg Rentsch, M. Chiesi (1996)
Regulation of ob gene mRNA levels in cultured adipocytesFEBS Letters, 379
F. Ofei, S. Hurel, J. Newkirk, M. Sopwith, Roy Taylor (1996)
Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDMDiabetes, 45
Z. Orban, A. Remaley, M. Sampson, Z. Trajanoski, G. Chrousos (1999)
The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man.The Journal of clinical endocrinology and metabolism, 84 6
V. Zilberfarb, K. Siquier, A. Strosberg, T. Issad (2001)
Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-α expression in human PAZ6 cellsDiabetologia, 44
G. Hotamisligil, P. Peraldi, A. Budavari, Ramsey Ellis, M. White, B. Spiegelman (1996)
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin ResistanceScience, 271
A. Kappes, G. Löffler (2000)
Influences of Ionomycin, Dibutyryl-cycloAMP and Tumour Necrosis Factor-alpha on Intracellular Amount and Secretion of apM1 in Differentiating Primary Human PreadipocytesHormone and Metabolic Research, 32
R. Rizza, L. Mandarino, J. Gerich (1982)
Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose UtilizationDiabetes, 31
R. Andrews, B. Walker (1999)
Glucocorticoids and insulin resistance: old hormones, new targets.Clinical science, 96 5
L. Slieker, K. Sloop, P. Surface, A. Kriauciunas, F. LaQuier, J. Manetta, J. Bue-Valleskey, T. Stephens (1996)
Regulation of Expression of ob mRNA and Protein by Glucocorticoids and cAMP (*)The Journal of Biological Chemistry, 271
H. Staiger, O. Tschritter, C. Kausch, R. Lammers, M. Stumvoll, Hans Häring (2002)
Human Serum Adiponectin Levels are not Under Short-Term Negative Control by Free Fatty Acids in VivoHormone and Metabolic Research, 34
N. Maeda, Masahiko Takahashi, T. Funahashi, S. Kihara, H. Nishizawa, K. Kishida, H. Nagaretani, M. Matsuda, R. Komuro, N. Ouchi, H. Kuriyama, K. Hotta, Tadashi Nakamura, I. Shimomura, Y. Matsuzawa (2001)
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.Diabetes, 50 9
D. Moller (2000)
Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes.Trends in endocrinology and metabolism: TEM, 11 6
A. Saltiel (2000)
Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases.The Journal of clinical investigation, 106 2
C. Steppan, Elizabeth Brown, C. Wright, Savitha Bhat, Ronadip Banerjee, C. Dai, Gregory Enders, D. Silberg, X. Wen, Gary Wu, M. Lazar (2001)
A family of tissue-specific resistin-like molecules.Proceedings of the National Academy of Sciences of the United States of America, 98 2
K. Hotta, T. Funahashi, Y. Arita, Masahiko Takahashi, M. Matsuda, Y. Okamoto, H. Iwahashi, H. Kuriyama, N. Ouchi, K. Maeda, M. Nishida, S. Kihara, N. Sakai, T. Nakajima, K. Hasegawa, M. Muraguchi, Y. Ohmoto, Tadashi Nakamura, S. Yamashita, T. Hanafusa, Y. Matsuzawa (2000)
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.Arteriosclerosis, thrombosis, and vascular biology, 20 6
E. Tomás, T. Tsao, A. Saha, H. Murrey, C. Zhang, Samar Itani, H. Lodish, N. Ruderman (2002)
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activationProceedings of the National Academy of Sciences of the United States of America, 99
Haiyan Xu, J. Hirosumi, K. Uysal, A. Guler, G. Hotamisligil (2002)
Exclusive Action of Transmembrane TNFα in Adipose Tissue Leads to Reduced Adipose Mass and Local But Not Systemic Insulin Resistance.Endocrinology, 143 4
P. Delhanty, D. Mesotten, Fiona Mcdougall, R. Baxter (2002)
Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats.Endocrinology, 143 6
S. Matthaei, M. Stumvoll, M. Kellerer, Hans Häring (2000)
Pathophysiology and pharmacological treatment of insulin resistance.Endocrine reviews, 21 6
S. Willi, A. Kennedy, P. Wallace, E. Ganaway, N. Rogers, W. Garvey (2002)
Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin.Diabetes, 51 10
G. Päth, S. Bornstein, M. Gurniak, G. Chrousos, W. Scherbaum, H. Hauner (2001)
Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function.The Journal of clinical endocrinology and metabolism, 86 5
M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke (2001)
Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes.Biochemical and biophysical research communications, 288 4
C. Sewter, Je Digby, Fiona Blows, Johannes Prins, Stephen O'Rahilly (1999)
Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro.The Journal of endocrinology, 163 1
S. Haffner, A. Greenberg, W. Weston, Hongzi Chen, K. Williams, M. Freed (2002)
Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes MellitusCirculation: Journal of the American Heart Association, 106
D. Papanicolaou, J. Petrides, C. Tsigos, S. Bina, K. Kalogeras, R. Wilder, P. Gold, P. Deuster, G. Chrousos (1996)
Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines.The American journal of physiology, 271 3 Pt 1
K. Nonogaki, G. Fuller, Nelson Fuentes, A. Moser, I. Staprans, C. Grunfeld, K. Feingold (1995)
Interleukin-6 stimulates hepatic triglyceride secretion in rats.Endocrinology, 136 5
Wei-Shiung Yang, Wei-Jei Lee, Tohru Funahashi, Sachiyo Tanaka, Yuji Matsuzawa, Chia-Ling Chao, Chi-Ling Chen, Tong-Yuan Tai, Lee-Ming Chuang (2001)
Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin.The Journal of clinical endocrinology and metabolism, 86 8
R. Xu, Qinling Wang, Ming Yan, M. Hernández, C. Gong, W. Boon, Y. Murata, Y. Ueta, Chen Chen (2002)
Orexin-A augments voltage-gated Ca2+ currents and synergistically increases growth hormone (GH) secretion with GH-releasing hormone in primary cultured ovine somatotropes.Endocrinology, 143 12
M. Fasshauer, M. Fasshauer, J. Klein, J. Klein, K. Kriauciunas, K. Ueki, M. Benito, C. Kahn (2001)
Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown AdipocytesMolecular and Cellular Biology, 21
A. Okuno, H. Tamemoto, K. Tobe, K. Ueki, Y. Mori, K. Iwamoto, K. Umesono, Y. Akanuma, T. Fujiwara, H. Horikoshi, Y. Yazaki, T. Kadowaki (1998)
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.The Journal of clinical investigation, 101 6
Terry Combs, J. Wagner, J. Berger, T. Doebber, Wen-jun Wang, Bei Zhang, M. Tanen, A. Berg, S. O’Rahilly, D. Savage, K. Chatterjee, S. Weiss, P. Larson, K. Gottesdiener, B. Gertz, M. Charron, P. Scherer, D. Moller (2002)
Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization.Endocrinology, 143 3
Sophie Haliakon, L. Doaré, F. Foufelle, M. Kergoat, M. Guerre-Millo, M. Berthault, I. Dugail, J. Morin, J. Auwerx, P. Ferré (1997)
Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa RatDiabetes, 46
M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke (2002)
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.Biochemical and biophysical research communications, 290 3
X. Chen, K. Lee, D. Hartzell, R. Dean, G. Hausman, R. McGraw, M. Della-Fera, C. Baile (2001)
Adipocyte insensitivity to insulin in growth hormone-transgenic mice.Biochemical and biophysical research communications, 283 4
J. Gerich (1998)
The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity.Endocrine reviews, 19 4
A. Ward, C. Fall, C. Stein, K. Kumaran, S. Veena, P. Wood, H. Syddall, D. Phillips (2003)
Cortisol and the metabolic syndrome in South AsiansClinical Endocrinology, 58
K. Ma, A. Cabrero, P. Saha, Hideto Kojima, Lan Li, B. Chang, A. Paul, L. Chan (2002)
Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin*The Journal of Biological Chemistry, 277
N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, H. Nagaretani, N. Furuyama, H. Kondo, Masahiko Takahashi, Y. Arita, R. Komuro, N. Ouchi, S. Kihara, Y. Tochino, K. Okutomi, M. Horie, S. Takeda, T. Aoyama, T. Funahashi, Y. Matsuzawa (2002)
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Nature Medicine, 8
C. Steppan, S. Bailey, Savitha Bhat, Elizabeth Brown, Ronadip Banerjee, C. Wright, H. Patel, R. Ahima, M. Lazar (2001)
The hormone resistin links obesity to diabetesNature, 409
H. Hauner (2002)
The mode of action of thiazolidinedionesDiabetes/Metabolism Research and Reviews, 18
C. Mantzoros, R. Frederich, J. Flier, D. Qu, V. Susulic, B. Lowell, E. Maratos-Flier (1996)
Activation of β3 Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in MiceDiabetes, 45
G. Hotamışlıgil, R. Johnson, R. Distel, Ramsey Ellis, V. Papaioannou, B. Spiegelman (1996)
Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding ProteinScience, 274
M. Fasshauer, S. Kralisch, M. Klier, U. Lossner, M. Bluher, J. Klein, R. Paschke (2003)
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes.Biochemical and biophysical research communications, 301 4
C. Weyer, T. Funahashi, Sachiyo Tanaka, K. Hotta, Y. Matsuzawa, R. Pratley, P. Tataranni (2001)
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.The Journal of clinical endocrinology and metabolism, 86 5
H. Makimura, T. Mizuno, H. Bergen, C. Mobbs (2002)
Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA.American journal of physiology. Endocrinology and metabolism, 283 6
Y. Nakano, T. Tobe, N. Choi-Miura, T. Mazda, Motowo Tomita (1996)
Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma.Journal of biochemistry, 120 4
M. Blüher, J. Kratzsch, R. Paschke (2001)
Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance.Diabetes care, 24 2
Stith Rd, J. Luo (1994)
Endocrine and carbohydrate responses to interleukin-6 in vivo.Circulatory shock, 44 4
S. Lay, Jeremie Boucher, Astrid Rey, I. Castan-Laurell, S. Krief, Pascal Ferré, Philippe Valet, Isabelle Dugail (2001)
Decreased resistin expression in mice with different sensitivities to a high-fat diet.Biochemical and biophysical research communications, 289 2
C. Fernández-Galaz, T. Fernández‐Agulló, C. Pérez, S. Peralta, C. Arribas, A. Andrés, J. Carrascosa, M. Ros (2002)
Long-term food restriction prevents ageing-associated central leptin resistance in wistar ratsDiabetologia, 45
G. Sesmilo, B. Biller, J. Llevadot, D. Hayden, G. Hanson, N. Rifai, A. Klibanski (2000)
Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial.Annals of internal medicine, 133 2
B. Bülow, B. Ahrén, E. Erfurth (2001)
Increased leptin and tumour necrosis factor alpha per unit fat mass in hypopituitary women without growth hormone treatment.European journal of endocrinology, 145 6
G. Hotamisligil, N. Shargill, B. Spiegelman (1993)
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.Science, 259 5091
G. Reaven, H. Lithell, L. Landsberg (1996)
Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system.The New England journal of medicine, 334 6
Piet Vos, R. Saladin, J. Auwerx, B. Staels (1995)
Induction of ob Gene Expression by Corticosteroids Is Accompanied by Body Weight Loss and Reduced Food Intake (*)The Journal of Biological Chemistry, 270
A. Thirone, C. Carvalho, S. Brenelli, L. Velloso, M. Saad (1997)
Effect of chronic growth hormone treatment on insulin signal transduction in rat tissuesMolecular and Cellular Endocrinology, 130
H. Nishizawa, I. Shimomura, K. Kishida, N. Maeda, H. Kuriyama, H. Nagaretani, M. Matsuda, H. Kondo, N. Furuyama, S. Kihara, Tadashi Nakamura, Y. Tochino, T. Funahashi, Y. Matsuzawa (2002)
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.Diabetes, 51 9
M. Blüher, M. Michael, O. Peroni, K. Ueki, Nathan Carter, B. Kahn, C. Kahn (2002)
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.Developmental cell, 3 1
S. Fried, D. Bunkin, A. Greenberg (1998)
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid.The Journal of clinical endocrinology and metabolism, 83 3
I. Hansen, E. Tsalikian, B. Beaufrère, J. Gerich, M. Haymond, R. Rizza (1986)
Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action.The American journal of physiology, 250 3 Pt 1
C. Grunfeld, K. Feingold (1991)
The metabolic effects of tumor necrosis factor and other cytokinesBiotherapy, 3
M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke (2001)
Tumor Necrosis Factor α Is a Negative Regulator of Resistin Gene Expression and Secretion in 3T3-L1 AdipocytesBiochemical and Biophysical Research Communications, 288
A. Pradhan, J. Manson, N. Rifai, Julie Buring, P. Ridker (2001)
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.JAMA, 286 3
Bei Zhang, M. Graziano, T. Doebber, M. Leibowitz, Sylvia White-Carrington, D. Szalkowski, P. Hey, Margaret Wu, C. Cullinan, Philip Bailey, Bettina Lollmann, R. Frederich, J. Flier, C. Strader, Roy Smith (1996)
Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (*)The Journal of Biological Chemistry, 271
Wei-Shiung Yang, C. Jeng, Ta‐Jen Wu, Sachiyo Tanaka, T. Funahashi, Y. Matsuzawa, Jao-Ping Wang, Chi-Ling Chen, T. Tai, L. Chuang (2002)
Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients.Diabetes care, 25 2
P. Kern, M. Saghizadeh, J. Ong, R. Bosch, R. Deem, R. Simsolo (1995)
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.The Journal of clinical investigation, 95 5
N. Shojima, H. Sakoda, T. Ogihara, M. Fujishiro, H. Katagiri, M. Anai, Y. Onishi, Hiraku Ono, K. Inukai, Miho Abe, Y. Fukushima, M. Kikuchi, Y. Oka, T. Asano (2002)
Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.Diabetes, 51 6
Joseph Yu, S. Javorschi, A. Hevener, Y. Kruszynska, R. Norman, M. Sinha, J. Olefsky (2002)
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.Diabetes, 51 10
J. Stephens, J. Lee, P. Pilch (1997)
Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.The Journal of biological chemistry, 272 2
Brennan, Rahim, Blum, Adams, Eden, Shalet (1999)
Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity?Clinical Endocrinology, 50
M. Delporte, T. Funahashi, Masahiko Takahashi, Y. Matsuzawa, S. Brichard (2002)
Pre- and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion: in vitro and in vivo studies.The Biochemical journal, 367 Pt 3
I. Nagaev, U. Smith (2001)
Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.Biochemical and biophysical research communications, 285 2
B. Vozarova, C. Weyer, Kristin Hanson, P. Tataranni, C. Bogardus, R. Pratley (2001)
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion.Obesity research, 9 7
T. Yamauchi, J. Kamon, H. Waki, Y. Imai, N. Shimozawa, K. Hioki, Shoko Uchida, Yusuke Ito, Keisuke Takakuwa, J. Matsui, M. Takata, K. Eto, Y. Terauchi, K. Komeda, M. Tsunoda, K. Murakami, Y. Ohnishi, T. Naitoh, K. Yamamura, Y. Ueyama, P. Froguel, S. Kimura, R. Nagai, T. Kadowaki (2003)
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis*The Journal of Biological Chemistry, 278
V. Rotter, I. Nagaev, U. Smith (2002)
Interleukin-6 (IL-6) Reduces Gene and Protein Expression of IRS-1 and GLUT4 and Is Overexpressed in Human Fat Cells from Insulin-Resistant SubjectsDiabetes, 51
Haiyan Xu, K. Uysal, J. Becherer, P. Arner, G. Hotamisligil (2002)
Altered Tumor Necrosis Factor-α (TNF-α) Processing in Adipocytes and Increased Expression of Transmembrane TNF-α in ObesityDiabetes, 51
A. Berg, Terry Combs, Xueliang Du, M. Brownlee, P. Scherer (2001)
The adipocyte-secreted protein Acrp30 enhances hepatic insulin actionNature Medicine, 7
Régis Saladin, P. Vos, Michele Guerre-Millot, A. Leturque, J. Girard, B. Staels, J. Auwerx (1995)
Transient increase in obese gene expression after food intake or insulin administrationNature, 377
M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke (2001)
Adiponectin gene expression is inhibited by β‐adrenergic stimulation via protein kinase A in 3T3‐L1 adipocytesFEBS Letters, 507
C. Halleux, Masahiko Takahashi, M. Delporte, R. Detry, T. Funahashi, Y. Matsuzawa, S. Brichard (2001)
Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue.Biochemical and biophysical research communications, 288 5
H. Masuzaki, J. Paterson, H. Shinyama, N. Morton, J. Mullins, J. Seckl, J. Flier (2001)
A Transgenic Model of Visceral Obesity and the Metabolic SyndromeScience, 294
M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke (2001)
Isoproterenol inhibits resistin gene expression through a GS‐protein‐coupled pathway in 3T3‐L1 adipocytesFEBS Letters, 500
J. Fruebis, T. Tsao, S. Javorschi, D. Ebbets-reed, M. Erickson, F. Yen, B. Bihain, H. Lodish (2001)
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.Proceedings of the National Academy of Sciences of the United States of America, 98 4
J. Senn, P. Klover, I. Nowak, R. Mooney (2002)
Interleukin-6 induces cellular insulin resistance in hepatocytes.Diabetes, 51 12
C. Tsigos, D. Papanicolaou, I. Kyrou, Ruby Defensor, C. Mitsiadis, G. Chrousos (1997)
Dose-dependent effects of recombinant human interleukin-6 on glucose regulation.The Journal of clinical endocrinology and metabolism, 82 12
P. Scherer, Suzanne Williams, M. Fogliano, G. Baldini, H. Lodish (1995)
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)The Journal of Biological Chemistry, 270
F. Haugen, Audun Jørgensen, C. Drevon, P. Trayhurn (2001)
Inhibition by insulin of resistin gene expression in 3T3‐L1 adipocytesFEBS Letters, 507
Haiyan Xu, J. Hirosumi, K. Uysal, A. Guler, G. Hotamisligil (2002)
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.Endocrinology, 143 4
T. Yamauchi, J. Kamon, Y. Minokoshi, Yoichi Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, Shunbun Kita, K. Ueki, Koji Eto, Y. Akanuma, P. Froguel, F. Foufelle, P. Ferré, D. Carling, Shigeko Kimura, R. Nagai, B. Kahn, T. Kadowaki (2002)
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseNature Medicine, 8
M. Kellerer, R. Lammers, A. Fritsche, V. Strack, F. Machicao, P. Borboni, A. Ullrich, H. Häring (2001)
Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistanceDiabetologia, 44
G. Sesmilo, B. Biller, J. Llevadot, D. Hayden, G. Hanson, N. Rifai, A. Klibanski (2000)
Effects of Growth Hormone Administration on Inflammatory and Other Cardiovascular Risk Markers in Men with Growth Hormone DeficiencyAnnals of Internal Medicine, 133
J. Janke, S. Engeli, K. Gorzelniak, F. Luft, Arya Sharma (2002)
Resistin gene expression in human adipocytes is not related to insulin resistance.Obesity research, 10 1
H. Nørrelund, C. Gravholt, P. Englaro, W. Blum, W. Rascher, J. Chistiansen, J. Jørgensen (1998)
Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients: lack of impact of different modes of GH administration.European journal of endocrinology, 138 6
Terry Smith, J. Elmendorf, Tonya David, Jiri Turinsky (1997)
Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4.The American journal of physiology, 272 6 Pt 1
Terry Combs, J. Wagner, J. Berger, T. Doebber, Wen-jun Wang, Bei Zhang, M. Tanen, A. Berg, S. O’Rahilly, D. Savage, K. Chatterjee, S. Weiss, P. Larson, K. Gottesdiener, B. Gertz, M. Charron, P. Scherer, D. Moller (2002)
Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization.Endocrinology, 143 3
T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, Shigeko Kimura, Motowo Tomita, P. Froguel, T. Kadowaki (2001)
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityNature Medicine, 7
T. Yamauchi, J. Kamon, Yusuke Ito, A. Tsuchida, T. Yokomizo, Shunbun Kita, T. Sugiyama, M. Miyagishi, K. Hara, M. Tsunoda, K. Murakami, T. Ohteki, Shoko Uchida, Sato Takekawa, H. Waki, N. Tsuno, Y. Shibata, Y. Terauchi, P. Froguel, K. Tobe, S. Koyasu, K. Taira, T. Kitamura, Takao Shimizu, R. Nagai, T. Kadowaki (2003)
Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 423
P. Kern, S. Ranganathan, Chunling Li, Linda Wood, G. Ranganathan (2001)
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.American journal of physiology. Endocrinology and metabolism, 280 5
C. Juan, Lo-Chun Au, Victor Fang, Shuo-Fen Kang, Ya-Hui Ko, Shu-Fang Kuo, Y. Hsu, C. Kwok, L. Ho (2001)
Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids.Biochemical and biophysical research communications, 289 5
Q. Zhong, Chia-yu Lin, K. Clarke, R. Kemppainen, D. Schwartz, R. Judd (2002)
Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes.Biochemical and biophysical research communications, 296 2
A. Ikeda, K. Chang, Y. Matsumoto, Y. Furuhata, M. Nishihara, F. Sasaki, Michio Takahashi (1998)
Obesity and insulin resistance in human growth hormone transgenic rats.Endocrinology, 139 7
S. Viengchareun, M. Zennaro, L. Tallec, M. Lombès (2002)
Brown adipocytes are novel sites of expression and regulation of adiponectin and resistinFEBS Letters, 532
M. Patti (1999)
Nutrient Modulation of Cellular Insulin ActionAnnals of the New York Academy of Sciences, 892
V. Vicennati, A. Vottero, C. Friedman, DA Papanicolaou (2002)
Hormonal regulation of interleukin-6 production in human adipocytesInternational Journal of Obesity, 26
E. Hu, P. Liang, B. Spiegelman (1996)
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (*)The Journal of Biological Chemistry, 271
K. Maeda, K. Okubo, I. Shimomura, T. Funahashi, Y. Matsuzawa, K. Matsubara (1996)
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).Biochemical and biophysical research communications, 221 2
M. Stumvoll, H. Häring (2002)
Glitazones: clinical effects and molecular mechanismsAnnals of Medicine, 34
G. Moore, H. Chapman, J. Holder, C. Lister, V. Piercy, S. Smith, J. Clapham (2001)
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.Biochemical and biophysical research communications, 286 4
H. Motoshima, Xiangdong Wu, M. Sinha, V. Hardy, E. Rosato, D. Barbot, F. Rosato, B. Goldstein (2002)
Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone.The Journal of clinical endocrinology and metabolism, 87 12
V. Mohamed-ali, L. Flower, Jaswinder Sethi, G. Hotamisligil, R. Gray, S. Humphries, D. York, J. Pinkney (2001)
β-Adrenergic regulation of IL-6 release from adipose tissue: In vivo and in vitro studiesThe Journal of Clinical Endocrinology and Metabolism, 86
J. Way, Cem Görgün, Q. Tong, K. Uysal, K. Brown, W. Harrington, W. Oliver, T. Willson, S. Kliewer, G. Hotamisligil (2001)
Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists*The Journal of Biological Chemistry, 276
M. Hulver, J. Houmard, W. Kraus, W. Pories, K. Macdonald, And Dohm, D. Zheng, C. Tanner, C. Slentz, M. Sinha, G. Lynis, Dohm, W. Hulver (2002)
Adiponectin is not altered with exercise training despite enhanced insulin action.American journal of physiology. Endocrinology and metabolism, 283 4
G. Milan, M. Granzotto, A. Scarda, A. Calcagno, C. Pagano, G. Federspil, R. Vettor (2002)
Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss.Obesity research, 10 11
Haiyan Xu, K. Uysal, J. Becherer, P. Arner, G. Hotamisligil (2002)
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.Diabetes, 51 6
N. Asada, Y. Takahashi, M. Honjo (2001)
Effects of 22K or 20K Human Growth Hormone on Lipolysis, Leptin Production in Adipocytes in the Presence and Absence of Human Growth Hormone Binding ProteinHormone Research in Paediatrics, 54
D. Moller (2000)
Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 DiabetesTrends in Endocrinology & Metabolism, 11
A. Cheung, D. Ree, J. Kolls, J. Fuselier, D. Coy, M. Bryer‐Ash (1998)
An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha.Endocrinology, 139 12
Y. Fukui, K. Motojima (2002)
Expression of resistin in the adipose tissue is modulatedby various factors including peroxisome proliferator‐activated receptor αDiabetes, 4
P. Vos, A. Lefebvre, Stephen Miller, M. Guerre-Millo, K. Wong, R. Saladin, L. Hamann, B. Staels, M. Briggs, J. Auwerx (1996)
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.The Journal of clinical investigation, 98 4
M. Fasshauer, J. Klein, U. Lossner, R. Paschke (2003)
Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 35 3
J. Spranger, A. Kroke, M. Möhlig, M. Bergmann, M. Ristow, H. Boeing, A. Pfeiffer (2003)
Adiponectin and protection against type 2 diabetes mellitusThe Lancet, 361
Michael Rajala, S. Obici, P. Scherer, L. Rossetti (2003)
Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production.The Journal of clinical investigation, 111 2
Megumi Miyakawa, Toshio Tsushima, H. Murakami, Osamu Isozaki, Hiroshi Demura, Toshiaki Tanaka (1998)
Effect of growth hormone (GH) on serum concentrations of leptin: study in patients with acromegaly and GH deficiency.The Journal of clinical endocrinology and metabolism, 83 10
V. Mohamed-ali, S. Goodrick, A. Rawesh, D. Katz, J. Miles, J. Yudkin, S. Klein, S. Coppack (1997)
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.The Journal of clinical endocrinology and metabolism, 82 12
J. Stephens, Jongsoon Lee, P. Pilch (1997)
Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction*The Journal of Biological Chemistry, 272
S. Damjanovic, M. Petakov, S. Raicevic, D. Micić, J. Marinković, C. Diéguez, F. Casanueva, V. Popović (2000)
Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by trans-sphenoidal surgery.The Journal of clinical endocrinology and metabolism, 85 1
L. Hardie, D. Rayner, Stephen Holmes, P. Trayhurn (1996)
Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA.Biochemical and biophysical research communications, 223 3
M. Fasshauer, J. Klein, K. Ueki, K. Kriauciunas, M. Benito, M. White, C. Kahn (2000)
Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes*The Journal of Biological Chemistry, 275
It has long been known that obesity and insulin resistance are linked. Recently, it has been shown that adipocytes secrete several proteins including tumour necrosis factor-α, interleukin-6, resistin, and adiponectin. Since several of these so-called adipocytokines influence insulin sensitivity and glucose metabolism profoundly, they might provide a molecular link between increased adiposity and impaired insulin sensitivity. Thiazolidinediones which decrease insulin resistance and are used in the treatment of Type 2 diabetes seem to mediate part of their insulin-sensitising effects via modulation of adipocytokine expression. Furthermore, hormones such as β-adrenergic agonists, insulin, glucocorticoids, and growth hormone might impair insulin sensitivity at least in part via up-regulation or down-regulation of adipocytokine synthesis. We summarise the current knowledge on how major adipocyte-secreted proteins are regulated by hormones and drugs influencing insulin sensitivity and discuss its implications for insulin resistance and obesity.
Diabetologia – Springer Journals
Published: Dec 1, 2003
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