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Intrastriatal injection of dl -2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine

Intrastriatal injection of dl -2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy... 213 90 90 1 1 W. J. Schmidt Biologisches Institut der Universität Stuttgart Ulmer Straße 227 D-7000 Stuttgart 60 Federal Republic of Germany Abstract dl -2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing. In both behavioural situations it was shown that AP-5 (10 μg/0.5 μl) induced continuous intensive sniffing similar to that induced by small doses of systemically administered amphetamine or apomorphine. However, oral stereotypies were not induced by AP-5. Systemically injected clozapine (5 and 10 mg/kg SC) as well as haloperidol (0.1 mg/kg IP) antagonized AP-5-induced sniffing. These results show that besides dopamine receptors, NMDA receptors are involved in the control of sniffing. In behavioural terms, the effect of glutamate mediated by the NMDA receptor in the striatum is opposite to that of dopamine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Intrastriatal injection of dl -2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine

Psychopharmacology , Volume 90 (1) – Aug 1, 1986

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References (32)

Publisher
Springer Journals
Copyright
Copyright © 1986 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00172883
Publisher site
See Article on Publisher Site

Abstract

213 90 90 1 1 W. J. Schmidt Biologisches Institut der Universität Stuttgart Ulmer Straße 227 D-7000 Stuttgart 60 Federal Republic of Germany Abstract dl -2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing. In both behavioural situations it was shown that AP-5 (10 μg/0.5 μl) induced continuous intensive sniffing similar to that induced by small doses of systemically administered amphetamine or apomorphine. However, oral stereotypies were not induced by AP-5. Systemically injected clozapine (5 and 10 mg/kg SC) as well as haloperidol (0.1 mg/kg IP) antagonized AP-5-induced sniffing. These results show that besides dopamine receptors, NMDA receptors are involved in the control of sniffing. In behavioural terms, the effect of glutamate mediated by the NMDA receptor in the striatum is opposite to that of dopamine.

Journal

PsychopharmacologySpringer Journals

Published: Aug 1, 1986

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