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Eva Link (1988)
The mechanism of pH-dependent hydrogen peroxide cytotoxicity in vitro.Archives of biochemistry and biophysics, 265 2
B. Halliwell, M. Grootveld (1987)
The measurement of free radical reactions in humansFEBS Letters, 213
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Mechanisms of lipid peroxidation potentiated by ischemia in the brain . In : Halliwell B , ed . Oxygen Radicals and Tissue Injury
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Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.Free radical research communications, 2 1-2
T. Singer, A. Trevor, N. Castagnoli (1987)
Biochemistry of the neurotoxic action of MPTP: or how a faulty batch of ‘designer drug’ led to parkinsonism in drug abusersTrends in Biochemical Sciences, 12
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Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity.Biochemical and biophysical research communications, 147 3
B. Halliwell (1987)
Oxidants and human disease: some new concepts 1The FASEB Journal, 1
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Superoxide inactivates creatine phosphokinase during reperfusion of ischemic heart
Donald NatvigS, Karin Imlayq, Daniele Touatill, Robert Hallewe (1987)
Human copper-zinc superoxide dismutase complements superoxide dismutase-deficient Escherichia coli mutants.The Journal of biological chemistry, 262 30
A. Puppo, B. Halliwell (1989)
Oxidation of dimethylsulphoxide to formaldehyde by oxyhaemoglobin and oxyleghaemoglobin in the presence of hydrogen peroxide is not mediated by "free" hydroxyl radicals.Free radical research communications, 5 4-5
J. Liccione, M. Maines (1988)
Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese.The Journal of pharmacology and experimental therapeutics, 247 1
A. Puppo, Barry HalliwellT (1988)
Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?The Biochemical journal, 249 1
Arthur Rosen, N. Frumin (1979)
Focal epileptogenesis after intracortical hemoglobin injectionExperimental Neurology, 66
D. Dexter, F. Wells, A. Lees, F. Agid, Y. Agid, P. Jenner, C. Marsden (1989)
Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's DiseaseJournal of Neurochemistry, 52
P. Chan, S. Longar, R. Fishman (1987)
Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edemaAnnals of Neurology, 21
T. Singer, R. Ramsay, K. McKeown (1988)
Biochemistry Of The Neurotoxic Action Of MPTP And What It May Teach Us About The Etiology Of Idiopathic Parkinsonism
G. Quinlan, B. Halliwell, C. Moorhouse, J. Gutteridge (1988)
Action of lead(II) and aluminium (III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions.Biochimica et biophysica acta, 962 2
J. Braughler, J. Pregenzer, R. Chase, L. Duncan, E. Jacobsen, J. Mccall (1987)
Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.The Journal of biological chemistry, 262 22
B. Halliwell (1989)
Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury, 5
J. Imlay, J. Imlay, S. Linn (1988)
DNA damage and oxygen radical toxicity.Science, 240 4857
M. Laughton, B. Halliwell, P. Evans, J. Hoult (1989)
Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA.Biochemical pharmacology, 38 17
D. McConkey, P. Hartzell, P. Nicotera, A. Wyllie, S. Orrenius (1988)
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Singer Singer, Trevor Trevor, Castagnoli Castagnoli (1987)
Biochemistry of the neurotoxic action of MPTPTrends Biochem Sci, 12
B. Halliwell, O. Aruoma, G. Mufti, A. Bomford (1988)
Bleomycin‐detectable iron in serum from leukaemic patients before and after chemotherapy Therapeutic implications for treatment with oxidant‐generating drugsFEBS Letters, 241
B. Halliwell (1989)
Superoxide, iron, vascular endothelium and reperfusion injury.Free radical research communications, 5 6
I. Fridovich (1978)
The biology of oxygen radicals.Science, 201 4359
R. Menghini (1988)
Genotoxicity of active oxygen species in mammalian cells.Mutation research, 195 3
B. Halliwell, J. Gutteridge (1986)
Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts.Archives of biochemistry and biophysics, 246 2
J. Langston, I. Irwin, G. Ricaurte (1987)
Neurotoxins, parkinsonism and Parkinson's disease.Pharmacology & therapeutics, 32 1
Oxygen free radicals in central nervous system ischemia and trauma
J. Birchall, J. Chappell (1988)
ALUMINIUM, CHEMICAL PHYSIOLOGY, AND ALZHEIMER'S DISEASEThe Lancet, 332
Edward Hall, P. Yonkers, John McCall, J. Braughler (1988)
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Guanyl nucleotide interactions with dopaminergic binding sites labeled by [3H]spiroperidol in human caudate and putamen: guanyl nucleotides enhance ascorbate-induced lipid peroxidation and cause an apparent loss of high affinity binding sites.Molecular pharmacology, 33 2
J. Dykens, A. Stern, E. Trenkner (1987)
Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue InjuryJournal of Neurochemistry, 49
J. Stocks, J. Gutteridge, Rosemary Sharp, T. Dormandy (1974)
The inhibition of lipid autoxidation by human serum and its relation to serum proteins and alpha-tocopherol.Clinical science and molecular medicine, 47 3
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Pathology of Oxygen ToxicityJournal of Clinical Pathology, 36
Edward Hall (1988)
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B. Halliwell (1989)
Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action?Free radical biology & medicine, 7 6
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M. Youdim (1988)
Brain iron : neurochemical and behavioural aspects
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B. Halliwell, J. Hoult, D. Blake (1988)
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A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).Biochemical pharmacology, 33 20
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The role of iron-induced hippocampal peroxidation in acute epileptogenesisBrain Research, 382
Blake Blake, Winyard Winyard, Lunec Lunec, Williams Williams, Good Good, Gutteridge Gutteridge, Rowley Rowley, Halliwell Halliwell, Hider Hider (1985)
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J. Gutteridge, G. Quinlan, I. Clark, B. Halliwell (1985)
Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts.Biochimica et biophysica acta, 835 3
C. Stevens (1988)
A relaxing factor in the brainNature, 336
B. Halliwell (1984)
Manganese ions, oxidation reactions and the superoxide radical.Neurotoxicology, 5 1
Kanner Kanner, German German, Kinsella Kinsella (1987)
Initiation of lipid peroxidation in biological systemsCRC Crit Rev Food Sci Nutr, 25
B. Halliwell, O. Aruoma, M. Wasil, J. Gutteridge (1988)
The resistance of transferrin, lactoferrin and caeruloplasmin to oxidative damage.The Biochemical journal, 256 1
A. Loon, B. Pesold-Hurt, G. Schatz (1986)
A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen.Proceedings of the National Academy of Sciences of the United States of America, 83 11
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M. Kyle, D. Nakae, I. Sakaida, S. Miccadei, J. Farber (1988)
Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide.The Journal of biological chemistry, 263 8
M. Youdim (1988)
Iron in the brain: implications for Parkinson's and Alzheimer's diseases.The Mount Sinai journal of medicine, New York, 55 1
A. Betz (1985)
Identification of Hypoxanthine Transport and Xanthine Oxidase Activity in Brain CapillariesJournal of Neurochemistry, 44
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Lipid peroxidation products : formation , chemical properties and biological activities
F. Archibald, C. Tyree (1987)
Manganese poisoning and the attack of trivalent manganese upon catecholamines.Archives of biochemistry and biophysics, 256 2
G. Martinovits, E. Melamed, O. Cohen, J. Rosenthal, A. Uzzan (1986)
Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)Neuroscience Letters, 69
B. Siesjö, G. Béndek, T. Koide, E. Westerberg, T. Wieloch (1985)
Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitroJournal of Cerebral Blood Flow & Metabolism, 5
Aromatic hydroxylation and uric acid degradation as methods for detecting and measuring oxygen radicals in vivo and in vitro
H. Mickel, Y. Vaishnav, O. Kempski, D. Lubitz, J. Weiss, Giora Feuerstein (1987)
Breathing 100% oxygen after global brain ischemia in Mongolian Gerbils results in increased lipid peroxidation and increased mortality.Stroke, 18 2
H. Pall, D. Blake, J. Gutteridge, AdrianC. Williams, J. Lunec, Michael Hall, Andrew Taylor (1987)
RAISED CEREBROSPINAL-FLUID COPPER CONCENTRATION IN PARKINSON'S DISEASEThe Lancet, 330
(1988)
Cellular and biochemical events in oxidant injury
Curnutte Curnutte, Babior Babior (1987)
Chronic granulomatous diseaseAdv Hum Genet, 16
M. Hayashi, T. Slater (1986)
Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes.Free radical research communications, 2 3
B. Halliwell, J. Gutteridge (1984)
LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPYThe Lancet, 323
Kok Lim, Mark Connolly, Daniel Rose, Felix Siegman, Jacobowitz Ij, A. Acinapura, Joseph Cunningham (1986)
Prevention of reperfusion injury of the ischemic spinal cord: use of recombinant superoxide dismutase.The Annals of thoracic surgery, 42 3
J. Turrens, J. Crapo, B. Freeman (1984)
Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.The Journal of clinical investigation, 73 1
Halliwell Halliwell, Aruoma Aruoma, Mufti Mufti, Bomford Bomford (1988)
Bleomycindetectable iron in serum from leukaemic patients before and after chemotherapyFEBS Lett, 241
(1977)
Effect of chlorpromazine on central nervous system concentrations of manganese , iron and copper
A. Patt, A. Harken, L. Burton, T. Rodell, D. Piermattei, Wagner Schorr, Natalie, B. Parker, Elaine Berger, Irene Horesh, L. Terada, Stuart Linas, John Cheronis, J. Repine (1988)
Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.The Journal of clinical investigation, 81 5
Edward Hall, P. Yonkers, John McCall (1988)
Attenuation of hemorrhagic shock by the non-glucocorticoid 21-aminosteroid U74006F.European journal of pharmacology, 147 2
E. Hall, P. Yonkers (1988)
Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F.Stroke, 19 3
B. Halliwell, J. Gutteridge (1985)
Free radicals in biology and medicine
Abstract– Radicals are species containing one or more unpaired electrons. The oxygen radical superoxide (O2‐) and the non‐radical oxidant hydrogen peroxide (H2O2) are produced during normal metabolism and perform several useful functions. Excessive production of O2‐ and H2O2 can result in tissue damage, which often involves generation of highly‐reactive hydroxyl radical (·OH) and other oxidants in the presence of “catalytic'’iron ions. A major form of antioxidant defence is the storage and transport of iron ions in forms that will not catalyze formation of reactive radicals. Tissue injury, eg. by ischaemia or trauma, can cause increased iron availability and accelerate free radical reactions. This may be especially important in the brain, since areas of this organ are rich in iron and cerebrospinal fluid cannot bind released iron ions. Oxidant stress upon nervous tissue can produce damage by several interacting mechanisms, including rises in intracellular free Ca2‐ and, possibly, release of excitatory amino acids. Recent suggestions that iron‐dependent free radical reactions are involved in the neurotoxicity of aluminium and in damage to the substantia nigra in Parkinson's disease are reviewed. Finally, the nature of antioxidants is discussed, it being suggested that antioxidant enzymes and chelators of iron ions may be more generally‐useful protective agents than chain‐breaking antioxidants.
Acta Neurologica Scandinavica – Wiley
Published: Nov 1, 1989
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