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A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS PLATXSXLVII-LII. A transmissible sarcoma of the chicken has been under observation in this laboratory for the past fourteen months, 1 and it has assumed of late a special interest because of its extreme malignancy and a tendency to wide-spread metastasis3 In a careful study of the growth, tests have been made to determine whether it can be transmitted by a filtrate free of the tumor cells. Attempts to so transmit rat, mouse, and dog tumors have never succeeded; and it was supposed that the sarcoma of the fowl would not differ from them in this regard, since it is a typical neoplasm. On the contrary, small quantities of a cell-free filtrate have sufficed to transmit the growth to susceptible fowls. EXPERIMENTS. For the first experiments on this point', ordinary filter paper was used, and the ground tumor was suspended in Ringer's solution. It was supposed that the slight paper barrier, which allows the passage of a few red blood cells and lymphocytes, would suffice to hold back the tumor and render the filtrate innocuous. Such has been the experience of other workers, with rat, mouse, and dog tumors. But in the present instance characteristic growths followed the inoculation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

The Journal of Experimental Medicine , Volume 13 (4): 397 – Apr 1, 1911

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Publisher
Rockefeller University Press
Copyright
Copyright © 1911 by The Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.13.4.397
Publisher site
See Article on Publisher Site

Abstract

PLATXSXLVII-LII. A transmissible sarcoma of the chicken has been under observation in this laboratory for the past fourteen months, 1 and it has assumed of late a special interest because of its extreme malignancy and a tendency to wide-spread metastasis3 In a careful study of the growth, tests have been made to determine whether it can be transmitted by a filtrate free of the tumor cells. Attempts to so transmit rat, mouse, and dog tumors have never succeeded; and it was supposed that the sarcoma of the fowl would not differ from them in this regard, since it is a typical neoplasm. On the contrary, small quantities of a cell-free filtrate have sufficed to transmit the growth to susceptible fowls. EXPERIMENTS. For the first experiments on this point', ordinary filter paper was used, and the ground tumor was suspended in Ringer's solution. It was supposed that the slight paper barrier, which allows the passage of a few red blood cells and lymphocytes, would suffice to hold back the tumor and render the filtrate innocuous. Such has been the experience of other workers, with rat, mouse, and dog tumors. But in the present instance characteristic growths followed the inoculation

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Apr 1, 1911

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