Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Saeb-Lima, D. Oca, J. Albores–Saavedra (2008)
Merkel cell carcinoma with eccrine differentiation: a clinicopathologic study of 7 cases.Annals of diagnostic pathology, 12 6
A. Quttainah, A. Thoma, S. Salama (2002)
Clinical-pathological review of 14 cases of merkel cell carcinomaPlastic Surgery, 10
R. Kidd, W. Krawczyk, G. Wilgram (2004)
The merkel cell in human epidermis: its differentiation from other dendritic cellsArchiv für dermatologische Forschung, 241
M. Agelli, L. Clegg (2003)
Epidemiology of primary Merkel cell carcinoma in the United States.Journal of the American Academy of Dermatology, 49 5
Jean Kanitakis, S. Euvrard, B. Chouvet, A. Butnaru, A. Claudy (2006)
Merkel cell carcinoma in organ‐transplant recipients: report of two cases with unusual histological features and literature reviewJournal of Cutaneous Pathology, 33
Surveillance Research Program, National Cancer Institute SEER*Stat software, seer.cancer.gov/seerstat version
R. Williams, M. Morgan, I. Mathieson, H. Rabb (1998)
Merkel cell carcinoma in a renal transplant patient: increased incidence?Transplantation, 65 10
R. Viscidi, K. Shah (2008)
A Skin Cancer Virus?Science, 319
R. Boutilier, Leon Desormeau, F. Cragg, Peter Roberts, N. Walsh (2001)
Merkel cell carcinoma: squamous and atypical fibroxanthoma-like differentiation in successive local tumor recurrences.The American Journal of dermatopathology, 23 1
R. Sibley, D. Dahl (1985)
Primary neuroendocrine (Merkel cell?) carcinoma of the skin: II. An immunocytochemical study of 21 casesThe American Journal of Surgical Pathology, 9
(2001)
eds. SEER summary staging manual-2000: codes and coding instructions, NIH Publication No. 01-4969
M. Foschini, V. Eusebi (2000)
Divergent differentiation in endocrine and nonendocrine tumors of the skin.Seminars in diagnostic pathology, 17 2
O. Carpentier, I. Carrotte-Lefebvre, P. Patenôtre, X. Mirabel, E. Delaporte, F. Piette (2002)
[Primitive cutaneous neuroendocrine carcinomas or Merkel's tumor. Clinical and therapeutic aspects in 22 patients].Presse medicale, 31 16
N. Silvestris, F. D'elia, G. Tarantino, A. Lucarelli (2000)
Merkel cell carcinoma in a renal transplant patient.Journal of experimental & clinical cancer research : CR, 19 3
T. Connelly, B. Cribier, T. Brown, I. Yanguas (2000)
Complete Spontaneous Regression of Merkel Cell Carcinoma: A Review of the 10 Reported CasesDermatologic Surgery, 26
R. Sibley, L. Dehner, J. Rosai (1985)
Primary neuroendocrine (Merkel cell?) carcinoma of the skin: I. A clinicopathologic and ultrastructural study of 43 casesThe American Journal of Surgical Pathology, 9
R. Mir, J. Sciubba, T. Bhuiya, K. Blomquist, D. Zelig, E. Friedman (1988)
Merkel cell carcinoma arising in the oral mucosa.Oral surgery, oral medicine, and oral pathology, 65 1
A. Kassem, Anja Schöpflin, Carlos Díaz, W. Weyers, E. Stickeler, M. Werner, A. Hausen (2008)
Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene.Cancer research, 68 13
M. Manganoni, C. Farisoglio, G. Tucci, M. Venturini, D. Marocolo, M. Aquilano, I. El-Hamad, V. Ferrari, P. Pinton (2007)
Merkel cell carcinoma and HIV infection: a case report and review of the literature.AIDS patient care and STDs, 21 7
C. Schmid, A. Beham, J. Feichtinger, L. Auböck, O. Dietze (1992)
Recurrent and subsequently metastasizing Merkel cell carcinoma in a 7‐year‐old girlHistopathology, 20
J. Chan, S. Suster, B. Wenig, W. Tsang, Janet Chan, Andy Lau (1997)
Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites.The American journal of surgical pathology, 21 2
N. Walsh (2001)
Primary neuroendocrine (Merkel cell) carcinoma of the skin: morphologic diversity and implications thereof.Human pathology, 32 7
Bottles K (1984)
Merkel cell carcinoma of the vulvaObstet Gynecol, 63
A. Fornelli, V. Eusebi, G. Pasquinelli, P. Quattrone, J. Rosai (2001)
Merkel cell carcinoma of the parotid gland associated with Warthin tumour: report of two casesHistopathology, 39
M. Heath, N. Jaimes, B. Lemos, A. Mostaghimi, Linda Wang, P. Peñas, P. Nghiem (2008)
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.Journal of the American Academy of Dermatology, 58 3
R. Sibley, J. Rosai, E. Foucar, L. Dehner, G. Bosl (1980)
Neuroendocrine (Merkel cell) carcinoma of the skin: A histologic and ultrastructural study of two casesThe American Journal of Surgical Pathology, 4
H. Feng, M. Shuda, Yuan Chang, P. Moore (2008)
Clonal Integration of a Polyomavirus in Human Merkel Cell CarcinomaScience, 319
V. Eusebi, C. Capella, A. Cossu, J. Rosai (1992)
Neuroendocrine Carcinoma Within Lymph Nodes in the Absence of a Primary Tumor, With Special Reference to Merkel Cell CarcinomaThe American Journal of Surgical Pathology, 16
Hwang Hwang, Alanen Alanen, Dabbs Dabbs, Danyluk Danyluk, Silverman Silverman (2008)
Merkel cell carcinoma with sarcomatous differentiationJ Cutan Pathol, 35
H. Goepfert, D. Remmler, E. Silva, B. Wheeler (1984)
Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck.Archives of otolaryngology, 110 11
A. Brucks, G. Schaeg, H. Mensing (2008)
Primäres neuroendokrines Merkel-Zell-Karzinom der HautDMW, 114
M. Iacocca, J. Abernethy, C. Stefanato, A. Allan, J. Bhawan (1998)
Mixed Merkel cell carcinoma and squamous cell carcinoma of the skin.Journal of the American Academy of Dermatology, 39 5 Pt 2
Jin Tanahashi, K. Kashima, T. Daa, N. Yada, S. Fujiwara, S. Yokoyama (2009)
Merkel cell carcinoma co‐existent with sebaceous carcinoma of the eyelidJournal of Cutaneous Pathology, 36
A. Gil-Moreno, Á. García-Jiménez, J. Gonzalez-Bosquet, M. Esteller, J. Castellví-Vives, J. Palones, J. Xercavins (1997)
Merkel cell carcinoma of the vulva.Gynecologic oncology, 64 3
A. Urbatsch, W. Sams, M. Urist, R. Sturdivant (1999)
Merkel cell carcinoma occurring in renal transplant patients.Journal of the American Academy of Dermatology, 41 2 Pt 2
M. Fernández-Figueras, L. Puig, M. Gilaberte, María Gómez‐Plaza, J. Rex, C. Ferrándiz, A. Ariza (2002)
Merkel cell (primary neuroendocrine) carcinoma of the skin with nodal metastasis showing rhabdomyosarcomatous differentiationJournal of Cutaneous Pathology, 29
K. Hohaus, E. Köstler, J. Schönlebe, E. Klemm, U. Wollina (2003)
Merkel cell carcinoma – a retrospective analysis of 17 casesJournal of the European Academy of Dermatology and Venereology, 17
G. Sidhu, H. Feiner, T. Flotte, J. Mullins, K. Schaefler, S. Schultenover (1980)
Merkel cell neoplasms: Histology, electron microscopy, biology, and histogenesisThe American Journal of Dermatopathology, 2
C. Brown (1983)
The statistical comparison of relative survival rates.Biometrics, 39 4
Lunder Lunder, Stern Stern (1998)
Merkel cell carcinomas treated with methoxsalen and ultraviolet A radiationN Engl J Med, 22
(1969)
SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence-SEER Regs Limited-Use
R. Moll, Ingrid Moll, W. Franke (1984)
Identification of Merkel cells in human skin by specific cytokeratin antibodies: changes of cell density and distribution in fetal and adult plantar epidermis.Differentiation; research in biological diversity, 28 2
Gould Gould, Albores‐Saavedra Albores‐Saavedra, Dubner Dubner, Smith Smith, Payne Payne (1988)
Eccrine and squamous differentiation in Merkel cell carcinomaAm J Surg Pathol, 12
O’Connor WJ (1996)
Merkel cell carcinomaDermatol Surg, 22
E. Gould, J. Albores–Saavedra, B. Dubner, C. Payne (1988)
Eccrine and Squamous Differentiation in Merkel Cell Carcinoma: An Immunohistochemical StudyThe American Journal of Surgical Pathology, 12
L. Gómez, Elvio Silva, S. Dimaio, B. Mackay (1983)
Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skinThe American Journal of Surgical Pathology, 7
Ning Li, G. Wolgamot, Z. Argényi (2007)
Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinomaJournal of Cutaneous Pathology, 34
M. Lehrer, D. Hershock, M. Ming (2004)
Merkel cell carcinomaCurrent Treatment Options in Oncology, 5
C. Bordea, F. Wojnarowska, P. Millard, H. Doll, K. Welsh, P. Morris (2004)
Skin cancers in renal-transplant recipients occur more frequently than previously recognized in a temperate climateTransplantation, 77
F. Lardy, C. Gautier, S. Etesse-Pichon, J. Martin, H. Demeaux, M. Géniaux, M. Delaunay (1996)
[Post-radiotherapy cutaneous neuro-endocrine carcinoma].Annales de dermatologie et de venereologie, 123 8
H. Lien, T. Tsai, Yu‐Yun Lee, C. Hsiao (1999)
Merkel cell carcinoma and chronic arsenicism.Journal of the American Academy of Dermatology, 41 4
B. Vieites, J. Suárez-Peñaranda, V. Delgado, H. Vázquez-Veiga, J. Varela, J. Forteza (2008)
Merkel cell carcinoma associated with in situ and invasive squamous cell carcinoma.Acta dermato-venereologica, 89 2
Houdna Ensaleh, P. Perney, O. Dereure, J. Guilhou, B. Guillot (2007)
Merkel Cell Carcinoma in a Liver Transplant PatientAmerican Journal of Clinical Dermatology, 8
C. Toker (1972)
Trabecular carcinoma of the skin.Archives of dermatology, 105 1
F. Lardy, C. Gautier, S. Etesse-Pichon, Martin Jc, H. Demeaux, M. Géniaux, Delaunay Mm (1996)
Carcinome neuro-endocrine cutané en zone irradiéeAnnales De Dermatologie Et De Venereologie, 123
E. Acebo, N. Vidaurrazaga, C. Varas, JJ Burgos‐Bretones, J. Díaz‐Pérez (2005)
Merkel cell carcinoma: a clinicopathological study of 11 casesJournal of the European Academy of Dermatology and Venereology, 19
E. Lunder, R. Stern (1998)
Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation.The New England journal of medicine, 339 17
X. Sastre-Garau, M. Peter, M. Avril, H. Laude, J. Couturier, F. Rozenberg, A. Almeida, F. Boitier, A. Carlotti, B. Couturaud, N. Dupin (2009)
Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesisThe Journal of Pathology, 218
June Hwang, K. Alanen, K. Dabbs, J. Danyluk, S. Silverman (2008)
Merkel cell carcinoma with squamous and sarcomatous differentiationJournal of Cutaneous Pathology, 35
Background: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun‐exposed skin of older and usually immunosuppressed individuals. Methods: Using data from NCI's SEER (Surveillance, Epidemiology, and End Results) Program from 1973 to 2006, we analyzed the demographics and survival of MCC. Results: SEER had recorded 3870 cases of MCC. The incidence was higher in men (2380 cases, 61.5%) than in women (1490 cases, 38.5%). Most patients were White (94.9%) between 60 and 85 years of age. MCC was rare in Blacks. The most common location was the head and neck. The salivary glands, nasal cavity, lip, lymph nodes, vulva, vagina and esophagus were the most common extracutaneous sites. The 10‐year relative survival rate was higher in women than men (64.8% vs. 50.5%, p < 0.001). Patients 50–69 years had the highest 10‐year relative survival rate (59.6%). Stage of disease was the best predictor of survival. Conclusions: MCC arises predominantly in the skin of head and neck in White men above 70 years of age. Cases also occurred in extracutaneous sites. Age did not predict survival, yet gender, site and tumor size revealed clear differences. The most significant predictor of survival was tumor stage.
Journal of Cutaneous Pathology – Wiley
Published: Jan 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.