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EFFECTS OF ORAL TESTOSTERONE UNDECANOATE IN HYPOGONADAL MALE PATIENTS *

EFFECTS OF ORAL TESTOSTERONE UNDECANOATE IN HYPOGONADAL MALE PATIENTS * SUMMARY Effects on plasma T, DHT, A, FSH, LH and PRL concentrations and the pituitary responsiveness to the LHRH/TRH stimulation, as well as on libido and sexual, mental and physical activities were studied in ten hypogonadal male patients undergoing therapy with oral testosterone undecanoate (TU) for 9 weeks. The daily dose of TU needed for satisfactory clinical effect was 120 mg (6 cases) and 240 mg (4 cases). There was a significant rise in circulation androgen concentrations in all patients. Mean plasma T, DHT and A increased at 9 weeks from 1.20, 0.12 and 0.36 ng/ml to 4.34 (P < 0.0004), 0.39 (P < 0.0004) and 1.24 ng/ml (P < 0.005), respectively. In hypergonadotrophic patients (N = 6) plasma FSH and LH fell progressively (P < 0.05), while in hypogonadotrophic patients (N = 4) a marked rise in plasma FSH (P < 0.05) was found, while LH tended to rise as well. Base‐line plasma PRL remained unchanged. In three out of four patients with poor PRL response to TRH, normal responses were established after TU therapy. Increase in libido and sexual activity was reported by nine patients. An increase in mental and physical activity was found in seven and two patients, respectively. Tolerance was excellent. It was concluded that oral TU is an effective form of substitution therapy in male hypogonadal patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Endocrinology Wiley

EFFECTS OF ORAL TESTOSTERONE UNDECANOATE IN HYPOGONADAL MALE PATIENTS *

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References (17)

Publisher
Wiley
Copyright
Copyright © 1978 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0300-0664
eISSN
1365-2265
DOI
10.1111/j.1365-2265.1978.tb02216.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY Effects on plasma T, DHT, A, FSH, LH and PRL concentrations and the pituitary responsiveness to the LHRH/TRH stimulation, as well as on libido and sexual, mental and physical activities were studied in ten hypogonadal male patients undergoing therapy with oral testosterone undecanoate (TU) for 9 weeks. The daily dose of TU needed for satisfactory clinical effect was 120 mg (6 cases) and 240 mg (4 cases). There was a significant rise in circulation androgen concentrations in all patients. Mean plasma T, DHT and A increased at 9 weeks from 1.20, 0.12 and 0.36 ng/ml to 4.34 (P < 0.0004), 0.39 (P < 0.0004) and 1.24 ng/ml (P < 0.005), respectively. In hypergonadotrophic patients (N = 6) plasma FSH and LH fell progressively (P < 0.05), while in hypogonadotrophic patients (N = 4) a marked rise in plasma FSH (P < 0.05) was found, while LH tended to rise as well. Base‐line plasma PRL remained unchanged. In three out of four patients with poor PRL response to TRH, normal responses were established after TU therapy. Increase in libido and sexual activity was reported by nine patients. An increase in mental and physical activity was found in seven and two patients, respectively. Tolerance was excellent. It was concluded that oral TU is an effective form of substitution therapy in male hypogonadal patients.

Journal

Clinical Endocrinology – Wiley

Published: Oct 1, 1978

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