Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Freestone, K. Wolfsheimer, S. Kamerling, G. Church, J. Hamra, C. Bagwell (1991)
Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine.Equine veterinary journal, 23 3
K. Treiber, D. Kronfeld, T. Hess, R. Boston, P. Harris (2005)
Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses.American journal of veterinary research, 66 12
M. Donaldson, A. Jorgensen, J. Beech (2004)
Evaluation of suspected pituitary pars intermedia dysfunction in horses with laminitis.Journal of the American Veterinary Medical Association, 224 7
J. Cartmill, D. Thompson, W. Storer, L. Gentry, N. Huff (2003)
Endocrine responses in mares and geldings with high body condition scores grouped by high vs. low resting leptin concentrations.Journal of animal science, 81 9
R. Carter, R. Geor, W. Staniar, T. Cubitt, P. Harris (2009)
Apparent adiposity assessed by standardised scoring systems and morphometric measurements in horses and ponies.Veterinary journal, 179 2
S. Bailey, N. Menzies‐Gow, P. Harris, J. Habershon-Butcher, C. Crawford, Y. Berhane, R. Boston, J. Elliott (2007)
Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis.Journal of the American Veterinary Medical Association, 231 9
K. Treiber, D. Kronfeld, T. Hess, B. Byrd, R. Splan, W. Staniar (2006)
Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies.Journal of the American Veterinary Medical Association, 228 10
M. Zweig, G. Campbell (1993)
Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.Clinical chemistry, 39 4
M. Smithson (2000)
Statistics with confidence
G. Perkins, S. Lamb, H. Erb, B. Schanbacher, D. Nydam, T. Divers (2010)
Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide.Equine veterinary journal, 34 7
R. Hoffman, R. Boston, D. Stefanovski, D. Kronfeld, P. Harris (2003)
Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings.Journal of animal science, 81 9
K. Treiber, T. Hess, D. Kronfeld, R. Boston, R. Geor, P. Harris (2007)
Insulin resistance and compensation in laminitis-predisposed ponies characterized by the Minimal ModelPferdeheilkunde Equine Medicine, 21
K. Asplin, M. Sillence, C. Pollitt, C. McGowan (2007)
Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies.Veterinary journal, 174 3
W. Taylor, N. Unwin (2009)
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
Philip Johnson (2002)
The equine metabolic syndrome peripheral Cushing's syndrome.The Veterinary clinics of North America. Equine practice, 18 2
R. Gibson (1990)
Principles of Nutritional Assessment
S. Bailey, J. Habershon-Butcher, K. Ransom, J. Elliott, N. Menzies‐Gow (2008)
Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.American journal of veterinary research, 69 1
C. McManus, B. Fitzgerald (2000)
Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin, and metabolites in aged and young mares.Domestic animal endocrinology, 19 1
Brad Biggerstaff (2000)
Comparing diagnostic tests: a simple graphic using likelihood ratios.Statistics in medicine, 19 5
K. Alberti, P. Zimmet (1998)
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO ConsultationDiabetic Medicine, 15
N. Frank, S. Elliott, R. Boston (2008)
Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses.American journal of veterinary research, 69 1
S. Pratt, R. Geor, J. McCutcheon (2005)
Repeatability of 2 methods for assessment of insulin sensitivity and glucose dynamics in horses.Journal of veterinary internal medicine, 19 6
J. Coffman, C. Colles (1983)
Insulin tolerance in laminitic ponies.Canadian journal of comparative medicine : Revue canadienne de medecine comparee, 47 3
L. Jeffcott, J. Field, J. Mclean, K. O'dea (1986)
Glucose tolerance and insulin sensitivity in ponies and Standardbred horses.Equine veterinary journal, 18 2
Preston Buff, A. Dodds, C. Morrison, N. Whitley, E. McFadin, J. Daniel, Jean Djiane, D. Keisler (2002)
Leptin in horses: tissue localization and relationship between peripheral concentrations of leptin and body condition.Journal of animal science, 80 11
D. Henneke, G. Potter, J. Kreider, B. Yeates (1983)
Relationship between condition score, physical measurements and body fat percentage in mares.Equine veterinary journal, 15 4
N. Frank, S. Elliott, Laura Brandt, D. Keisler (2006)
Physical characteristics, blood hormone concentrations, and plasma lipid concentrations in obese horses with insulin resistance.Journal of the American Veterinary Medical Association, 228 9
J. Am. med. Ass., 285
J. Cartmill, D. Thompson, W. Storer, J. Crowley, N. Huff, C. Waller (2005)
Effect of dexamethasone, feeding time, and insulin infusion on leptin concentrations in stallions.Journal of animal science, 83 8
P. Harris, S. Bailey, J. Elliott, A. Longland (2006)
Countermeasures for pasture-associated laminitis in ponies and horses.The Journal of nutrition, 136 7 Suppl
K. Murphy, S. Bloom (2006)
Are all fats created equal?Nature Medicine, 12
M. Vick, A. Adams, B. Murphy, D. Sessions, D. Horohov, R. Cook, B. Shelton, B. Fitzgerald (2007)
Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse.Journal of animal science, 85 5
D. McFarlane, J. Beech, A. Cribb (2006)
Alpha-melanocyte stimulating hormone release in response to thyrotropin releasing hormone in healthy horses, horses with pituitary pars intermedia dysfunction and equine pars intermedia explants.Domestic animal endocrinology, 30 4
Summary Reasons for performing study: The ability to predict ponies at increased risk of laminitic episodes, when exposed to nutrient dense pasture, would facilitate management to avoid disease. Objectives: To identify variables and clinically useful cut‐off values with reproducible diagnostic accuracy for the prediction of ponies that subsequently developed laminitis when exposed to nutrient dense pasture. Methods: A cohort of predominantly Welsh and Dartmoor ponies from a closed herd was evaluated in March 2006 (n = 74) and March 2007 (n = 57). Ponies were categorised as never laminitic or previously laminitic according to reported laminitic history and as clinically laminitic (CL) if laminitis was observed within 3 months following evaluation. Body condition score (BCS), cresty neck score (CNS), girth and neck circumferences (NC), withers height, blood pressure and hoof surface temperature, and plasma insulin, glucose, triglyceride, leptin, cortisol, ACTH, uric acid and TNF‐α concentrations were measured. Analysis of sensitivity, specificity and receiver operating characteristic curves was used to evaluate the diagnostic accuracy for a variable to predict CL ponies. Results: Variables with diagnostic accuracy for the prediction of CL ponies included insulin, leptin, BCS, CNS, and NC:height ratio. Specific cut‐off values of insulin (>32 mu/l), leptin (>7.3 ng/ml), BCS (≥7), CNS (≥4) and NC:height ratio (>0.71) had reproducible diagnostic accuracy for the prediction of laminitis. Combining tests did not result in higher diagnostic accuracy than individual tests of insulin or leptin during either evaluation. Conclusions: Tests of insulin and leptin concentrations and measures of generalised (BCS) and localised (CNS or NC:height ratio) obesity were beneficial in the prediction of laminitic episodes. Potential relevance: These results highlight the importance of monitoring and reducing insulin concentration, and generalised and regional obesity in ponies to reduce risk of laminitis.
Equine Veterinary Journal – Wiley
Published: Feb 1, 2009
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.