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EVALUATION OF d2, A MICROSATELLITE MEASURE OF INBREEDING AND OUTBREEDING, IN WOLVES WITH A KNOWN PEDIGREE

EVALUATION OF d2, A MICROSATELLITE MEASURE OF INBREEDING AND OUTBREEDING, IN WOLVES WITH A KNOWN... Abstract.— We have evaluated a microsatellite measure proposed as an indicator of inbreeding and outbreeding using a captive wolf population with known inbreeding levels and founder sources. The measure, which is based on the difference in the repeat number for microsatellite alleles within an individual, was not more predictive of the known inbreeding coefficient than microsatellite heterozygosity (it was actually less predictive). We also found no support that the measure was predictive of the level of outbreeding. However, we could not determine if the measure was predictive of very low levels of inbreeding due to matings between remote relatives. Overall, it appears that the usefulness of this measure to identify individuals on the inbred‐outbred continuum beyond that of heterozygosity and identify biologically important associations with fitness‐related traits may be limited. We suggest that the measure be examined theoretically to determine when (and how much) the predictive value of the measure is different from that of heterozygosity for inbreeding or outbreeding levels in a variety of different scenarios. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Evolution Wiley

EVALUATION OF d2, A MICROSATELLITE MEASURE OF INBREEDING AND OUTBREEDING, IN WOLVES WITH A KNOWN PEDIGREE

Hedrick, Philip; Fredrickson, Richard; Ellegren, Hans
Evolution , Volume 55 (6) – Jun 1, 2001
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References (20)

Publisher
Wiley
Copyright
Copyright © 2001 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0014-3820
eISSN
1558-5646
DOI
10.1111/j.0014-3820.2001.tb00646.x
Publisher site
See Article on Publisher Site

Abstract

Abstract.— We have evaluated a microsatellite measure proposed as an indicator of inbreeding and outbreeding using a captive wolf population with known inbreeding levels and founder sources. The measure, which is based on the difference in the repeat number for microsatellite alleles within an individual, was not more predictive of the known inbreeding coefficient than microsatellite heterozygosity (it was actually less predictive). We also found no support that the measure was predictive of the level of outbreeding. However, we could not determine if the measure was predictive of very low levels of inbreeding due to matings between remote relatives. Overall, it appears that the usefulness of this measure to identify individuals on the inbred‐outbred continuum beyond that of heterozygosity and identify biologically important associations with fitness‐related traits may be limited. We suggest that the measure be examined theoretically to determine when (and how much) the predictive value of the measure is different from that of heterozygosity for inbreeding or outbreeding levels in a variety of different scenarios.

Journal

Evolution – Wiley

Published: Jun 1, 2001

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