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Aging and stress-induced changes in complement activation and neutrophil mobilization

Aging and stress-induced changes in complement activation and neutrophil mobilization Cannon, Joseph G., Maria A. Fiatarone, Roger A. Fielding, William J. Evans. Aging stress-induced changes in complement activation neutrophil mobilization. J. A&. Physiol. 76(6): 2616-2620, 1994.-We measured the extent of complement activation neutrophil mobilization after eccentric exercise to determine whether these responses were age dependent whether they were associated with changes in plasma creatine kinase (CK), a marker for muscle membrane integrity. Repeated forced lengthening of a muscle as it develops tension causes immediate ultrastructural damage to sarcomeres, followed by delayed-onset muscle soreness release of myocellular enzymes. This can be accomplished in quadriceps muscles by running downhill or by resisting bicycle pedals driven backward by a motor. Twelve older (61-72 yr) 9 younger (20-32 yr) subjects performed one of these activities for 45 min at an intensity of 78 k 2% of maximum heart rate. For all subjects, a median increase of 21% in plasma desArg-C3a levels occurred immediately after the protocol, circulating increased 66 t 10% by 4-6 h, plasma CK increased 135k 25%by 24 h. The peak increases in correlated with the peak increases in des-Arg-C3a (rho = 0.662, P = 0.006), the peak increases in CK correlated with the rise in (rho = 0.523, P http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Aging and stress-induced changes in complement activation and neutrophil mobilization

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Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

Cannon, Joseph G., Maria A. Fiatarone, Roger A. Fielding, William J. Evans. Aging stress-induced changes in complement activation neutrophil mobilization. J. A&. Physiol. 76(6): 2616-2620, 1994.-We measured the extent of complement activation neutrophil mobilization after eccentric exercise to determine whether these responses were age dependent whether they were associated with changes in plasma creatine kinase (CK), a marker for muscle membrane integrity. Repeated forced lengthening of a muscle as it develops tension causes immediate ultrastructural damage to sarcomeres, followed by delayed-onset muscle soreness release of myocellular enzymes. This can be accomplished in quadriceps muscles by running downhill or by resisting bicycle pedals driven backward by a motor. Twelve older (61-72 yr) 9 younger (20-32 yr) subjects performed one of these activities for 45 min at an intensity of 78 k 2% of maximum heart rate. For all subjects, a median increase of 21% in plasma desArg-C3a levels occurred immediately after the protocol, circulating increased 66 t 10% by 4-6 h, plasma CK increased 135k 25%by 24 h. The peak increases in correlated with the peak increases in des-Arg-C3a (rho = 0.662, P = 0.006), the peak increases in CK correlated with the rise in (rho = 0.523, P

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Jun 1, 1994

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