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Hongyan Xiao, Richard Kovics, V. Jackson, D. Remick (2004)
Effects of platelet inhibitors on propyl gallate-induced platelet aggregation, protein tyrosine phosphorylation, and platelet factor 3 activationBlood Coagulation & Fibrinolysis, 15
E. Arias-Salgado, S. Lizano, Sugata Sarkar, J. Brugge, M. Ginsberg, S. Shattil (2003)
Src kinase activation by direct interaction with the integrin β cytoplasmic domainProceedings of the National Academy of Sciences of the United States of America, 100
Wen-Ling Shih, H. Hsu, M. Liao, L. Lee, Hung-Jen Liu (2004)
Avian reovirus σC protein induces apoptosis in cultured cellsVirology, 321
P. Irusta, Ying-bei Chen, J. Hardwick (2003)
Viral modulators of cell death provide new links to old pathways.Current opinion in cell biology, 15 6
K. Oda, H. Arakawa, Tomoaki Tanaka, K. Matsuda, C. Tanikawa, Toshiki Mori, H. Nishimori, K. Tamai, T. Tokino, Yusuke Nakamura, Y. Taya (2000)
p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53Cell, 102
M. Hilleman (2004)
Strategies and mechanisms for host and pathogen survival in acute and persistent viral infectionsProceedings of the National Academy of Sciences of the United States of America, 101
K. Yoshida, Hanshao Liu, Y. Miki (2006)
Protein Kinase C δ Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage*Journal of Biological Chemistry, 281
AV von Knethen, D Callsen, B Brüne (1999)
NF-κB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophagesMol Cell Biol, 10
Ralph Schuster, W. Gerlich, S. Schaefer (2000)
Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblastsOncogene, 19
G. D’Orazi, Barbara Cecchinelli, T. Bruno, I. Manni, Y. Higashimoto, Shinichi Saito, M. Gostissa, S. Coen, A. Marchetti, G. Sal, G. Piaggio, M. Fanciulli, E. Appella, S. Soddu (2002)
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosisNature Cell Biology, 4
M. Murillo, Gaelle Castillo, Aránzazu Sánchez, Margarita Fernández, I. Fabregat (2005)
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytesOncogene, 24
Aitor Granja, M. Nogal, C. Hurtado, J. Salas, M. Salas, Á. Carrascosa, Y. Revilla (2004)
Modulation of p53 Cellular Function and Cell Death by African Swine Fever VirusJournal of Virology, 78
W. Shih, M. Kuo, S. Chuang, A. Cheng, S. Doong (2003)
Hepatitis B Virus X Protein Activates a Survival Signaling by Linking Src to Phosphatidylinositol 3-Kinase*Journal of Biological Chemistry, 278
R. Reinehr, S. Becker, Andrea Höngen, Dieter Haüssinger (2004)
The Src Family Kinase Yes Triggers Hyperosmotic Activation of the Epidermal Growth Factor Receptor and CD95*Journal of Biological Chemistry, 279
P. Auwaerter, H. Kaneshima, J. McCune, J. McCune, G. Wiegand, D. Griffin (1996)
Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosisJournal of Virology, 70
R. Blake, M. Broome, Xiangdong Liu, Jianming Wu, M. Gishizky, Li Sun, S. Courtneidge (2000)
SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor SignalingMolecular and Cellular Biology, 20
Klára Megyeri, Klára Megyeri, Klara Berencsi, T. Halazonetis, George Prendergast, Giorgia Gri, Stanley Plotkin, Giovanni Rovera, E. Gonczol, E. Gonczol (1999)
Involvement of a p53-dependent pathway in rubella virus-induced apoptosis.Virology, 259 1
D. Bulavin, Shinichi Saito, M. Hollander, K. Sakaguchi, C. Anderson, E. Appella, A. Fornace (1999)
Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiationThe EMBO Journal, 18
A. Knethen, D. Callsen, B. Brüne (1999)
NF-κB and AP-1 Activation by Nitric Oxide Attenuated Apoptotic Cell Death in RAW 264.7 MacrophagesMolecular Biology of the Cell, 10
C. Brooks, W. Gu (2003)
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation.Current opinion in cell biology, 15 2
B. Dix, S. O'Carroll, C. Myers, S. Edwards, A. Braithwaite (2000)
Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53.Cancer research, 60 10
Y. Tanaka, Hiroshi Kobayashi, Mika Suzuki, N. Kanayama, T. Terao (2004)
Transforming Growth Factor-β1-dependent Urokinase Up-regulation and Promotion of Invasion Are Involved in Src-MAPK-dependent Signaling in Human Ovarian Cancer Cells*Journal of Biological Chemistry, 279
L. Devireddy, Clinton Jones (1999)
Activation of Caspases and p53 by Bovine Herpesvirus 1 Infection Results in Programmed Cell Death and Efficient Virus ReleaseJournal of Virology, 73
E. Razvi, R. Welsh (1995)
Apoptosis in viral infections.Advances in virus research, 45
Martin Gs (2001)
The hunting of the Src.Nature Reviews Molecular Cell Biology, 2
P. Krammer, I. Behrmann, Peter Daniel, J. Dhein, K. Debatin (1994)
Regulation of apoptosis in the immune system.Current opinion in immunology, 6 2
Jones Rc (2000)
Avian reovirus infections.Revue scientifique et technique, 19 2
Tatosyan Ag, Mizenina Oa (2000)
Kinases of the Src family: structure and functions.Biochemistry, 65
T. Narita, T. Nishimura, K. Yoshizaki, T. Taniyama (2005)
CIN85 associates with TNF receptor 1 via Src and modulates TNF-α-induced apoptosisExperimental Cell Research, 304
A. Cuadrado, L. García-Fernández, L. González, Y. Suárez, A. Losada, Victoria Alcaide, Teresa Martínez, J. Fernandez-Sousa, J. Sánchez-Puelles, A. Muñoz (2003)
AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK*The Journal of Biological Chemistry, 278
T. Finkel, G. Tudor-Williams, N. Banda, M. Cotton, T. Curiel, C. Monks, T. Baba, R. Ruprecht, A. Kupfer (1995)
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodesNature Medicine, 1
M. Weller, J. Schulz, U. Wüllner, P. Löschmann, T. Klockgether, J. Dichgans (1997)
Developmental and genetic regulation of programmed neuronal death.Journal of neural transmission. Supplementum, 50
Catarina Bjelfman, G. Meyerson, '. Cartwright, T. Karin, Mellstrom, Ulf Hammerling, Sven Påhlman (1990)
Early activation of endogenous pp60src kinase activity during neuronal differentiation of cultured human neuroblastoma cellsMolecular and Cellular Biology, 10
Zijuan Liu, Joy Falola, Xudong Zhu, Ying Gu, L. Kim, G. Sarosi, T. Anthony, F. Nwariaku (2004)
Antiproliferative effects of Src inhibition on medullary thyroid cancer.The Journal of clinical endocrinology and metabolism, 89 7
K. Webster, Joanna Parish, Maya Pandya, P. Stern, A. Clarke, K. Gaston (2000)
The Human Papillomavirus (HPV) 16 E2 Protein Induces Apoptosis in the Absence of Other HPV Proteins and via a p53-dependent Pathway*The Journal of Biological Chemistry, 275
P. Krajcsi, W. Wold (1998)
Viral proteins that regulate cellular signalling.The Journal of general virology, 79 ( Pt 6)
Yolande Pengetnze, M. Steed, K. Roby, P. Terranova, Christopher Taylor (2003)
Src tyrosine kinase promotes survival and resistance to chemotherapeutics in a mouse ovarian cancer cell line.Biochemical and biophysical research communications, 309 2
R. De, Rosenberger Jk (1989)
In vitro and in vivo characterization of avian reoviruses. III. Host factors affecting virulence and persistence.Avian Diseases, 33
Darian Rice, A. Dobrian, S. Schriver, R. Prewitt (2002)
Src Autophosphorylation is an Early Event in Pressure-Mediated Signaling Pathways in Isolated Resistance ArteriesHypertension: Journal of the American Heart Association, 39
C. Vasant, R. Rajaram, T. Ramasami (2003)
Apoptosis of lymphocytes induced by chromium(VI/V) is through ROS-mediated activation of Src-family kinases and caspase-3.Free radical biology & medicine, 35 9
S. Parsons, J. Parsons (2004)
Src family kinases, key regulators of signal transductionOncogene, 23
Masato OkadaS, Hachiro Nakagawa (1989)
A protein tyrosine kinase involved in regulation of pp60c-src function.The Journal of biological chemistry, 264 35
Á. Carrascosa, M. Bustos, M. Nogal, G. Buitrago, Y. Revilla (2002)
Apoptosis induced in an early step of African swine fever virus entry into vero cells does not require virus replication.Virology, 294 2
E. Appella, C. Anderson (2001)
Post-translational modifications and activation of p53 by genotoxic stresses.European journal of biochemistry, 268 10
Thelma Thompson, C. Tovar, Hong Yang, D. Carvajal, B. Vu, Qunli Xu, G. Wahl, D. Heimbrook, L. Vassilev (2004)
Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis*♦Journal of Biological Chemistry, 279
M. Scheffner, Takashi Takahashi, J. Huibregtse, J. Minna, P. Howley (1992)
Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteinsJournal of Virology, 66
I. Nicoletti, G. Migliorati, M. Pagliacci, F. Grignani, C. Riccardi (1991)
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.Journal of immunological methods, 139 2
S. Courtneidge, A. Heber (1987)
An 81 kd protein complexed with middle T antigen and pp60c-src : A possible phosphatidylinositol kinaseCell, 50
C. Costas, J. Martínez-Costas, G. Bodelón, J. Benavente (2005)
The Second Open Reading Frame of the Avian Reovirus S1 Gene Encodes a Transcription-Dependent and CRM1-Independent Nucleocytoplasmic Shuttling ProteinJournal of Virology, 79
D. Keller, X. Zeng, Yun Wang, Q. Zhang, M. Kapoor, Hongjun Shu, R. Goodman, G. Lozano, Y. Zhao, Hua Lu (2001)
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.Molecular cell, 7 2
J. Perfettini, M. Castedo, R. Nardacci, F. Ciccosanti, P. Boya, T. Roumier, N. Larochette, M. Piacentini, G. Kroemer (2005)
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelopeThe Journal of Experimental Medicine, 201
R. Reinehr, S. Becker, M. Wettstein, D. Häussinger (2004)
Involvement of the Src family kinase yes in bile salt-induced apoptosis.Gastroenterology, 127 5
Vincent O'Brien (1998)
Viruses and apoptosis.The Journal of general virology, 79 ( Pt 8)
H. Yoshizato, Minoru Tanaka, N. Nakai, N. Nakao, K. Nakashima (2004)
Growth hormone (GH)-stimulated insulin-like growth factor I gene expression is mediated by a tyrosine phosphorylation pathway depending on C-terminal region of human GH receptor in human GH receptor-expressing Ba/F3 cells.Endocrinology, 145 1
John Kerr, A. Wyllie, R. Alastair, Currie (1972)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue KineticsBritish Journal of Cancer, 26
Chien-Jung Hsu, Chi-Young Wang, L. Lee, Wen-Ling Shih, Chi Chang, Hsueh-Ling Cheng, Julius Chulu, Wen Ji, Hung-Jen Liu (2006)
Development and characterization of monoclonal antibodies against avian reovirus σC protein and their application in detection of avian reovirus isolatesAvian Pathology, 35
Yang Xu (2003)
Regulation of p53 responses by post-translational modificationsCell Death and Differentiation, 10
S. Yamano, T. Tokino, M. Yasuda, M. Kaneuchi, Minoru Takahashi, Y. Niitsu, K. Fujinaga, T. Yamashita (1999)
Induction of Transformation and p53-Dependent Apoptosis by Adenovirus Type 5 E4orf6/7 cDNAJournal of Virology, 73
R. Duncan, Z. Chen, S. Walsh, S. Wu (1996)
Avian reovirus-induced syncytium formation is independent of infectious progeny virus production and enhances the rate, but is not essential, for virus-induced cytopathology and virus egress.Virology, 224 2
B. Vogelstein, K. Kinzler (1992)
p53 function and dysfunctionCell, 70
X. Wang, K. Forrester, H. Yeh, M. Feitelson, Jen-Ren Gu, C. Harris (1994)
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.Proceedings of the National Academy of Sciences of the United States of America, 91 6
Brian Webb, E. Jimenez, G. Martin (2000)
v-Src Generates a p53-Independent Apoptotic SignalMolecular and Cellular Biology, 20
Yuqiao Shen, T. Shenk (1995)
Viruses and apoptosis.Current opinion in genetics & development, 5 1
L. Labrada, G. Bodelón, J. Viñuela, J. Benavente (2002)
Avian Reoviruses Cause Apoptosis in Cultured Cells: Viral Uncoating, but Not Viral Gene Expression, Is Required for Apoptosis InductionJournal of Virology, 76
D. Dreyfus, M. Nagasawa, C. Kelleher, E. Gelfand (2000)
Stable expression of Epstein-Barr virus BZLF-1-encoded ZEBRA protein activates p53-dependent transcription in human Jurkat T-lymphoblastoid cells.Blood, 96 2
SA Courtneidge, A Heber (1987)
An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinaseCell, 50
We have previously shown that avian reovirus (ARV) S1133 and its structural protein σC cause apoptosis in cultured Vero cells through an unknown intracellular signaling pathway. This work investigates how ARV S1133 induces proapoptotic signals. Upon ARV S1133 infection and subsequent apoptosis, levels of p53 mRNA and protein, and p53 serine-46 and serine-392 phosphorylation increased. In addition, p53-driven reporter activity and levels of the p53-induced apoptotic protein bax were increased, and Src tyrosine-418 phosphorylation was elevated. UV-inactivated virus failed to activate Src, p53 or induce apoptosis. Over-expression of dominant negative p53, or treatment with tyrosine kinase inhibitor genistein protected cells from ARV S1133-induced apoptosis. Inhibition of Src by over-expression of C-terminal Src kinase (Csk) or treatment with Src family tyrosine kinase inhibitor SU-6656 diminished the ARV S1133-induced p53 expression, activation, and apoptosis. Over-expression of σC resulted in the upregulation of p53, p53 serine-46 phosphorylation, p53-driven reporter activity and accumulation of bax. σC expression during ARV S1133 infection was concomitant with the onset of apoptosis. These studies provide strong evidence that the viral gene expression is required for ARV S1133 to initiate a proapoptotic signal via Src to p53. In addition, σC was able to utilize a p53-dependent pathway to elicit apoptosis.
Apoptosis – Springer Journals
Published: Oct 17, 2006
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