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Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum... DESPITE substantial advances in the management of extensive thermal burns, the mortality remains relatively high. In some cases, even when the cutaneous lesions do well, cardiotoxic complications appear and seem to be responsible for a fatal outcome. The purpose of this investigation was to identify the factors which may be responsible for these cardiotoxic and neurotoxic complications. Several investigators have reported the presence of toxic substances in skin and blood serum of burned experimental animals or of human patients, e.g. Allgower et al., 1973, Rosenthal et al., 1972. In a previous report (Moati et al., 1977) we have described the presence of cardiotoxic and neurotoxic factors in Cohn fractions obtained from the sera of burned patients. In the present paper we describe the purification and some of the properties of a lipoprotein which possesses neurotoxic activity. The purification and the properties of a cardiotoxic substance are described separately (Moati et d., 1979). We reported previously in vivo experiments showing that injections of fraction II+ 1x1 obtained by Cohn's fractionation procedure from burn sera induced neurotoxic symptoms in rabbits, rats and mice (Moati et al., 1977). In order to investigate the nature of the neurotoxic substances, fraction IIJrIII was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

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References (12)

Publisher
Wiley
Copyright
Copyright © 1979 The Pathological Society of Great Britain and Ireland
ISSN
0022-3417
eISSN
1096-9896
DOI
10.1002/path.1711270306
pmid
469639
Publisher site
See Article on Publisher Site

Abstract

DESPITE substantial advances in the management of extensive thermal burns, the mortality remains relatively high. In some cases, even when the cutaneous lesions do well, cardiotoxic complications appear and seem to be responsible for a fatal outcome. The purpose of this investigation was to identify the factors which may be responsible for these cardiotoxic and neurotoxic complications. Several investigators have reported the presence of toxic substances in skin and blood serum of burned experimental animals or of human patients, e.g. Allgower et al., 1973, Rosenthal et al., 1972. In a previous report (Moati et al., 1977) we have described the presence of cardiotoxic and neurotoxic factors in Cohn fractions obtained from the sera of burned patients. In the present paper we describe the purification and some of the properties of a lipoprotein which possesses neurotoxic activity. The purification and the properties of a cardiotoxic substance are described separately (Moati et d., 1979). We reported previously in vivo experiments showing that injections of fraction II+ 1x1 obtained by Cohn's fractionation procedure from burn sera induced neurotoxic symptoms in rabbits, rats and mice (Moati et al., 1977). In order to investigate the nature of the neurotoxic substances, fraction IIJrIII was

Journal

The Journal of PathologyWiley

Published: Mar 1, 1979

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