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Tolerance and selective cross-tolerance to the motivational effects of opioids

Tolerance and selective cross-tolerance to the motivational effects of opioids 213 96 96 1 1 T. S. Shippenberg M. W. Emmett-Oglesby F. J. Ayesta A. Herz Department of Neuropharmacology Max-Planck Institute for Psychiatry Am Klopferspitz 18a D-8033 Planegg-Martinsried Federal Republic of Germany Department of Pharmacology Texas College of Osteopathic Medicine 3516 Camp Bowie Boulevard 76107 Forth Worth TX USA Abstract The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the μ-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the κ-opioid agonist, U-69593 produced conditioned place aversions. Non-contingent administration of morphine (5.0 mg/kg/12 h) for 4 days prior to conditioning resulted in tolerance to its reinforcing effects, and cross-tolerance to the effects of fentanyl. No cross-tolerance to the motivational effects of the psychostimulant d -amphetamine or the κ-opioid agonist U-69593 was observed. Chronic administration of U-69593 prior to conditioning produced tolerance to its aversive effects. This treatment did not, however, modify the reinforcement produced by morphine. These data demonstrate that tolerance develops to both the reinforcing and aversive properties of opioids and suggest that differential cross-tolerance may provide a useful method for determining the pharmacological basis underlying drug-induced motivational effects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Tolerance and selective cross-tolerance to the motivational effects of opioids

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References (37)

Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02431542
Publisher site
See Article on Publisher Site

Abstract

213 96 96 1 1 T. S. Shippenberg M. W. Emmett-Oglesby F. J. Ayesta A. Herz Department of Neuropharmacology Max-Planck Institute for Psychiatry Am Klopferspitz 18a D-8033 Planegg-Martinsried Federal Republic of Germany Department of Pharmacology Texas College of Osteopathic Medicine 3516 Camp Bowie Boulevard 76107 Forth Worth TX USA Abstract The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the μ-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the κ-opioid agonist, U-69593 produced conditioned place aversions. Non-contingent administration of morphine (5.0 mg/kg/12 h) for 4 days prior to conditioning resulted in tolerance to its reinforcing effects, and cross-tolerance to the effects of fentanyl. No cross-tolerance to the motivational effects of the psychostimulant d -amphetamine or the κ-opioid agonist U-69593 was observed. Chronic administration of U-69593 prior to conditioning produced tolerance to its aversive effects. This treatment did not, however, modify the reinforcement produced by morphine. These data demonstrate that tolerance develops to both the reinforcing and aversive properties of opioids and suggest that differential cross-tolerance may provide a useful method for determining the pharmacological basis underlying drug-induced motivational effects.

Journal

Psychopharmacology – Springer Journals

Published: Sep 1, 1988

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