Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Paxinos, Charles Watson (1983)
The Rat Brain in Stereotaxic Coordinates
Ramesh Arora, H. Meltzer (1989)
Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients.Life sciences, 44 11
P. Chopin, M. Briley (1987)
Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmissionTrends in Pharmacological Sciences, 8
M. Linnoila, M. Eckardt, M. Durcan, R. Lister, P. Martin (1987)
Interactions of serotonin with ethanol: clinical and animal studies.Psychopharmacology bulletin, 23 3
D. Ceulemans, M. Hoppenbrouwers, Y. Gelders, A. Reyntjens (1985)
The Influence of Ritanserin, a Serotonin Antagonist, in Anxiety Disorders: A Double-blind Placebo-controlled Study versus LorazepamPharmacopsychiatry, 18
J. Murphy (1978)
Mianserin in the treatment of depressive illness and anxiety states in general practice.British journal of clinical pharmacology, 5 Suppl 1
I. Paul, G. Duncan, K. Powell, R. Mueller, J. Hong, G. Breese (1988)
Regionally specific neural adaptation of beta adrenergic and 5-hydroxytryptamine2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment.The Journal of pharmacology and experimental therapeutics, 246 3
Á. Pazos, J. Palacios (1985)
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptorsBrain Research, 346
Importance of 5 - HT 1 , receptors in the expression of forepaw treading and head twitches in rats
A. Bjertnaes, J. Block, P. Hafstad, M. Holte, I. Otremo, T. Larsen, R. Pinder, K. Stéffensen, S. Stulemeuer (1982)
A multicentre placebo‐controlled trial comparing the efficacy of mianserin and chlordiazepoxide in general practice patients with primary anxietyActa Psychiatrica Scandinavica, 66
M. Blackshear, E. sanders-Bush (1982)
Serotonin receptor sensitivity after acute and chronic treatment with mianserin.The Journal of pharmacology and experimental therapeutics, 221 2
J. Deakin (1988)
5HT2 receptors, depression and anxietyPharmacology Biochemistry and Behavior, 29
(1988)
Autoradiography of serotonin receptors
(1990)
Downregulation of 5 - HT 2 receptors underlies anxiolytic effect produced by sustained treatment with gepirone
Stephen Peroutka, Solomon Snyder (1980)
Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.Science, 210 4465
(1989)
Action of ritanserin and DO1 on the elevated X-maze. 990-996
S. Offord, G. Ordway, A. Frazer (1988)
Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat.The Journal of pharmacology and experimental therapeutics, 244 1
D. Benjamin, H. Lal, Laurence Meyerson (1990)
The effects of 5-HT1B characterizing agents in the mouse elevated plus-maze.Life sciences, 47 3
(1989)
Increased serotonin, (5-HT,) receptor binding
C. Niemegeers, F. Colpaert, J. Leysen, F. Awouters, P. Janseen (1983)
Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonistsDrug Development Research, 3
F. Granier, M. Girard, L. Schmitt, J. Boscredon, J. Oules, M. Escande (1985)
Depression and anxiety: mianserin and nomifensine compared in a double‐blind multicentre trialActa Psychiatrica Scandinavica, 72
J. Stutzmann, B. Eon, F. Darche, M. Lucas, J. Rataud, O. Piot, J. Blanchard, P. Laduron (1991)
Are 5-HT2 antagonists endowed with anxiolytic properties in rodents?Neuroscience Letters, 128
E. sanders-Bush, M. Breeding, M. Roznoski (1987)
5HT2 binding sites after mianserin: comparison of loss of sites and brain levels of drug.European journal of pharmacology, 133 2
M. Khan, E. Bennie, S. Stulemeijer, M. Ravens (1983)
Mianserin and doxepin in the treatment of outpatient depression with anxiety.British journal of clinical pharmacology, 15 Suppl 2
S. Pellow, P. Chopin, S. File, M. Briley (1985)
Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the ratJournal of Neuroscience Methods, 14
(1989)
Pharmacological profile of CGS 18102A, a proposed anxiolytic with 5-HT, agonist and 5-HT, antagonist properties
V. Bettum, M. Sørensen, J. Jørgensen, J. Viby-Mogensen, G. Dunbar, K. Stéffensen (1985)
A double‐blind group comparative study using the new anti‐depressant Org 3770, placebo and diazepam in patients with expected insomnia and anxiety before elective gynaecological surgeryActa Psychiatrica Scandinavica, 71
R. Kahn, D. Mcnair, R. Lipman, R. Lipman, L. Covi, K. Rickels, R. Downing, S. Fisher, S. Fisher, L. Frankenthaler (1986)
Imipramine and chlordiazepoxide in depressive and anxiety disorders. II. Efficacy in anxious outpatients.Archives of general psychiatry, 43 1
A. Reyntjens, Y. Gelders, M. Hoppenbrouwers, G. Bussche (1986)
Thymosthenic effects of ritanserin (R 55667), a centrally acting serotonin‐S2 receptor blockerDrug Development Research, 8
D. Mckenna, C. Mathis, A. Shulgin, T. Sargent, J. Saavedra (1987)
Autoradiographic localization of binding sites for 125I-DOI, a new psychotomimetic radioligand, in the rat brain.European journal of pharmacology, 137 2-3
A. Schotte, J. Leysen (1989)
Identification of 5-HT2 receptors, alpha 1-adrenoceptors and amine release sites in rat brain by autoradiography with [125I]7-amino-8-iodo-ketanserin.European journal of pharmacology, 172 2
Several agents that downregulate 5‐HT2 receptors produce anxiolytic effects in humans, but the role of 5‐HT2 receptor downregulation has been difficult to assess because of their other actions. To test the effects of pharmacological downregulation of 5‐HT2 receptors on exploratory behavior in the mouse, mianserin, a drug known to downregulate 5‐HT2 receptors after a single dose, was administered 30 min, 48 hr, or 18 days prior to testing in the elevated plus‐maze. Following testing in the elevated maze, the head‐shake response to 4‐iodo‐R‐(—)‐2,5‐dimethoxyphenylisopropylamine (DOI), a selective 5‐HT2/5‐HT1C agonist was assessed, and in a separate group of animals 5‐HT1A, 5‐HT1B, 5‐HT1C, β1,β2, and 5‐HT2 agonist and antagonist binding was quantified autoradiographically. Mianserin pretreatment resulted in a significant dose‐related anxiolytic effect in the elevated plus maze evidenced by increases in the percentage of entries to, and time spent on the open arms. Head‐shakes induced by DOI were also dose‐dependently decreased as a result of mianserin pretreatment. At this time, the binding of the 5‐HT2 receptor antagonist, 7‐amino‐8(125I)ketanserin was decreased by 50%. Binding of DOI to 5‐HT2 receptors was decreased by 46%, and to 5‐HT1C receptors was decreased by 53%, but no other changes were found in any of the other receptor types examined. These findings demonstrate that the 5‐HT2 receptor plays at least a permissive role in anxiety‐like behaviors, since an intact 5‐HT2 system is necessary for the full expression of the anxiety‐like response, but the role of 5‐HT1C receptor downregulation in the effects of mianserin cannot be ruled out at this time. © 1992 Wiley‐Liss, Inc.
Drug Development Research – Wiley
Published: Jan 1, 1992
Keywords: serotonin; anxiety; 5‐HT 1C ; receptors; autoradiography
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.