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E. Benveniste, V. Nguyen, D. Wesemann (2004)
Molecular regulation of CD40 gene expression in macrophages and microgliaBrain, Behavior, and Immunity, 18
E. Lutgens, D. Lievens, Linda Beckers, M. Donners, M. Daemen (2007)
CD40 and its ligand in atherosclerosis.Trends in cardiovascular medicine, 17 4
A. Mocali, Sabrina Cedrola, N. Malva, M. Bontempelli, Vicente Mitidieri, A. Bavazzano, Roberto Comolli, Francesco Paoletti, C. Porta (2004)
Increased plasma levels of soluble CD40, together with the decrease of TGFβ1, as possible differential markers of Alzheimer diseaseExperimental Gerontology, 39
S. Stamm, S. Ben‐Ari, I. Rafalska, Yesheng Tang, Zhaiyi Zhang, D. Toiber, T. Thanaraj, H. Soreq (2004)
Function of Alternative Splicing
S. Beinke, S. Ley (2004)
Functions of NF-?B1 and NF-?B2 in immune cell biologyBiochemical Journal
A. Basok, A. Shnaider, Limor Man, C. Chaimovitz, A. Douvdevani (2001)
CD40 is expressed on human peritoneal mesothelial cells and upregulates the production of interleukin-15 and RANTES.Journal of the American Society of Nephrology : JASN, 12 4
A. Aljada, J. Friedman, H. Ghanim, P. Mohanty, D. Hofmeyer, A. Chaudhuri, P. Dandona (2006)
Glucose ingestion induces an increase in intranuclear nuclear factor κB, a fall in cellular inhibitor κB, and an increase in tumor necrosis factor α messenger RNA by mononuclear cells in healthy human subjectsMetabolism-clinical and Experimental, 55
C. Larsen, E. Elwood, D. Alexander, S. Ritchie, R. Hendrix, C. Tucker-Burden, H. Cho, A. Aruffo, D. Hollenbaugh, P. Linsley, K. Winn, T. Pearson (1996)
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathwaysNature, 381
P. Dullforce, D. Sutton, A. Heath (1998)
Enhancement of T cell-independent immune responses in vivo by CD40 antibodiesNature Medicine, 4
Soluble CD40 may inhibit CD40/CD40L signalling by binding to the membrane CD40 and formatting, thus, a nonfunctional dimer, which is then degraded intracellularly
C. Contin, V. Pitard, Yahsou Delmas, N. Pelletier, T. Defrance, J. Moreau, P. Merville, J. Déchanet-Merville (2003)
Potential role of soluble CD40 in the humoral immune response impairment of uraemic patientsImmunology, 110
M. Yellin, S. Winikoff, S. Fortune, D. Baum, M. Crow, S. Lederman, L. Chess (1995)
Ligation of CD40 on fibroblasts induces CD54 (ICAM‐1) and CD106 (VCAM‐1) up‐regulation and IL‐6 production and proliferationJournal of Leukocyte Biology, 58
S. Ferrari, S. Giliani, A. Insalaco, A. Al-ghonaium, A. Soresina, M. Loubser, M. Avanzini, M. Marconi, R. Badolato, A. Ugazio, Y. Lévy, Nadia Catalan, A. Durandy, A. Tbakhi, L. Notarangelo, A. Plebani (2001)
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgMProceedings of the National Academy of Sciences of the United States of America, 98
M. Rolph, S. Kaufmann (2001)
CD40 Signaling Converts a Minimally Immunogenic Antigen into a Potent Vaccine Against the Intracellular Pathogen Listeria monocytogenesThe Journal of Immunology, 166
R. Baker, D. Wagner, K. Haskins (2008)
CD40 on NOD CD4 T cells contributes to their activation and pathogenicity.Journal of autoimmunity, 31 4
I. Berberich, G. Shu, F. Siebelt, J. Woodgett, J. Kyriakis, E. Clark (1996)
Cross‐linking CD40 on B cells preferentially induces stress‐activated protein kinases rather than mitogen‐activated protein kinases.The EMBO Journal, 15
B. Mosheimer, N. Kaneider, C. Feistritzer, A. Djanani, D. Sturn, J. Patsch, C. Wiedermann (2005)
CD40-ligand-dependent induction of COX-2 gene expression in endothelial cells by activated platelets: inhibitory effects of atorvastatinBlood Coagulation & Fibrinolysis, 16
(2002)
Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages
H. Qin, Cynthia Wilson, Sun Lee, E. Benveniste (2006)
IFN- (cid:1) -induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia
K. Garton, Peter Gough, Elaine Raines (2006)
Emerging roles for ectodomain shedding in the regulation of inflammatory responsesJournal of Leukocyte Biology, 79
R. Phipps, L. Koumas, E. Leung, S. Reddy, T. Blieden, J. Kaufman (2001)
The CD40-CD40 ligand system: a potential therapeutic target in atherosclerosis.Current opinion in investigational drugs, 2 6
J. Laman, M. Boer, B. Hart (1998)
CD40 in Clinical Inflammation: From Multiple Sclerosis to AtherosclerosisDevelopmental Immunology, 6
M. Tone, Y. Tone, J. Babik, Chun-Yen Lin, H. Waldmann (2002)
The Role of Sp1 and NF-κB in Regulating CD40 Gene Expression*The Journal of Biological Chemistry, 277
R. Phipps (2000)
Atherosclerosis: the emerging role of inflammation and the CD40-CD40 ligand system.Proceedings of the National Academy of Sciences of the United States of America, 97 13
Yali Chen, Jianjun Chen, Yanbao Xiong, Q. Da, Youli Xu, Xuejun Jiang, Hong Tang (2006)
Internalization of CD40 regulates its signal transduction in vascular endothelial cells.Biochemical and biophysical research communications, 345 1
(2002)
CD40 triggered human monocyte-derived 481
U. author., P. Libby (2001)
The CD40/CD154 receptor/ligand dyadRID="†"ID="†" ReviewCellular and Molecular Life Sciences CMLS, 58
Debra Miller, R. Yaron, M. Yellin (1998)
CD40L‐CD40 interactions regulate endothelial cell surface tissue factor and thrombomodulin expressionJournal of Leukocyte Biology, 63
G. Bishop, B. Hostager, K. Brown (2002)
Mechanisms of TNF receptor‐associated factor (TRAF) regulation in B lymphocytesJournal of Leukocyte Biology, 72
J. Karras, Z. Wang, L. Huo, D. Frank, T. Rothstein (1997)
Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement.Journal of immunology, 159 9
M. Melter, M. Reinders, M. Sho, S. Pal, C. Geehan, M. Denton, D. Mukhopadhyay, D. Briscoe (2000)
Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo.Blood, 96 12
A. Siwkowski, Leila Malik, Christine Esau, M. Maier, E. Wancewicz, Klaus Albertshofer, B. Monia, C. Bennett, A. Eldrup (2004)
Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing.Nucleic acids research, 32 9
B. Hart, H. Brok, S. Amor, R. Bontrop (2001)
The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levelsHuman Immunology, 62
U. Shu, M. Kiniwa, Chang‐you Wu, C. Maliszewski, N. Vezzio, J. Hakimi, M. Gately, G. Delespesse (1995)
Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interactionEuropean Journal of Immunology, 25
G. Ait-Ghezala, L. Abdullah, C. Volmar, D. Paris, C. Luis, A. Quadros, Benoit Mouzon, M. Mullan, A. Keegan, Julia Parrish, F. Crawford, V. Mathura, M. Mullan (2008)
Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease.Cytokine, 44 2
K. Siepmann, J. Skok, D. Essen, M. Harnett, D. Gray (2001)
Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory poolImmunology, 102
C. Kooten, Claude Gaillard, J. Galizzi, P. Hermann, F. Fossiez, J. Banchereau, D. Blanchard (1994)
B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40European Journal of Immunology, 24
Y. Inoue, T. Otsuka, H. Niiro, S. Nagano, Y. Arinobu, E. Ogami, M. Akahoshi, K. Miyake, I. Ninomiya, S. Shimizu, H. Nakashima, M. Harada (2004)
Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human MonocytesThe Journal of Immunology, 172
I. Grewal, R. Flavell (1996)
A central role of CD40 ligand in the regulation of CD4+ T-cell responses.Immunology today, 17 9
Changyi Chen, H. Chai, Xinwen Wang, Jun Jiang, M. Jamaluddin, D. Liao, Yuqing Zhang, Hao Wang, U. Bharadwaj, S. Zhang, Min Li, P. Lin, Q. Yao (2008)
Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells.Blood, 112 8
The type II CD40 mRNA isoform, a product of alternative splicing, is mainly responsible for the production of sCD40 (type I mRNA isoform encodes for the transmembrane CD40)
K. Hristov, K. Knox, V. Mitev (2005)
Regulation of tyrosine phosphorylation during the CD40-mediated rescue of Ramos-BL B cells from BCR-triggered apoptosis.International journal of molecular medicine, 16 5
D. Hollenbaugh, N. Mischel-Petty, C. Edwards, J. Simon, R. Denfeld, P. Kiener, A. Aruffo (1995)
Expression of functional CD40 by vascular endothelial cellsThe Journal of Experimental Medicine, 182
S. Chakrabarti, S. Varghese, O. Vitseva, K. Tanriverdi, J. Freedman (2005)
CD40 Ligand Influences Platelet Release of Reactive Oxygen IntermediatesArteriosclerosis, Thrombosis, and Vascular Biology, 25
A. Craxton, G. Shu, J. Graves, J. Saklatvala, E. Krebs, E. Clark (1998)
p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes.Journal of immunology, 161 7
M. Rizvi, Didi Pathak, J. Freedman, S. Chakrabarti (2008)
CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease.Trends in molecular medicine, 14 12
B. Hock, J. McKenzie, N. Patton, M. Drayson, K. Taylor, C. Wakeman, H. Kantarjian, F. Giles, M. Albitar (2006)
Circulating levels and clinical significance of soluble CD40 in patients with hematologic malignanciesCancer, 106
N. Holler, T. Kataoka, J. Bodmer, P. Romero, J. Romero, D. Deperthes, J. Engel, J. Tschopp, P. Schneider (2000)
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors.Journal of immunological methods, 237 1-2
D. Waid, R. Wagner, A. Putnam, G. Vaitaitis, N. Pennock, D. Calverley, P. Gottlieb, D. Wagner (2007)
A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes.Clinical immunology, 124 2
F. Mach, U. Schönbeck, R. Fabunmi, C. Murphy, Elizabeth Atkinson, J. Bonnefoy, P. Graber, P. Libby (1999)
T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: implications for tubule formation.The American journal of pathology, 154 1
K. Büchner, V. Henn, M. Gräfe, O. Boer, A. Becker, R. Kroczek (2003)
CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40–CD40L signalling in atherosclerosisThe Journal of Pathology, 201
C. Contin, V. Pitard, Toshimitsu Itai, S. Nagata, J. Moreau, J. Déchanet-Merville (2003)
Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling.The Journal of biological chemistry, 278 35
S. Maruo, M. Oh‐hora, H. Ahn, S. Ono, M. Wysocka, Y. Kaneko, H. Yagita, K. Okumura, H. Kikutani, T. Kishimoto, M. Kobayashi, T. Hamaoka, G. Trinchieri, H. Fujiwara (1997)
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.Journal of immunology, 158 1
K. Shiraki, K. Sugimoto, H. Okano, H. Wagayama, K. Fujikawa, T. Yamanaka, Takeshi Ito, S. Ohmori, Takahisa Sakai, K. Takase, T. Nakano (2006)
CD40 expression in HCV-associated chronic liver diseases.International journal of molecular medicine, 18 4
R. Vonderheide (2007)
Prospect of Targeting the CD40 Pathway for Cancer TherapyClinical Cancer Research, 13
A. Tedgui, Z. Mallat (2006)
Cytokines in atherosclerosis: pathogenic and regulatory pathways.Physiological reviews, 86 2
M. Hayden, S. Ghosh (2004)
Signaling to NF-kappaB.Genes & development, 18 18
V. Nguyen, E. Benveniste (2002)
Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.The Journal of biological chemistry, 277 16
D. Waid, G. Vaitaitis, D. Wagner (2004)
Peripheral CD4loCD40+ auto‐aggressive T cell expansion during insulin‐dependent diabetes mellitusEuropean Journal of Immunology, 34
M. Yellin, J. Brett, D. Baum, A. Matsushima, M. Szabolcs, David Stern, L. Chess (1995)
Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signalsThe Journal of Experimental Medicine, 182
R. Costello, J. Gastaut, D. Olive (1999)
What is the real role of CD40 in cancer immunotherapy?Immunology today, 20 11
E. Toubi, Y. Shoenfeld (2004)
The Role of CD40–CD154 Interactions in Autoimmunity and the Benefit of Disrupting this PathwayAutoimmunity, 37
D. Wagner, G. Vaitaitis, R. Sanderson, M. Poulin, Cathleen Dobbs, K. Haskins (2002)
Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetesProceedings of the National Academy of Sciences of the United States of America, 99
B. Werneburg, Stephen Zoog, Thu Dang, M. Kehry, J. Crute (2001)
Molecular Characterization of CD40 Signaling Intermediates*The Journal of Biological Chemistry, 276
David Parker, Dale Greiner, N. Phillips, Michael Appel, A. Steele, F. Durie, R. Noelle, J. Mordes, Aldo Rossini (1995)
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.Proceedings of the National Academy of Sciences of the United States of America, 92 21
Jinchuan Yan, Zonggui Wu, Jinming Chen, Li Li, Xiantao Kong (2004)
Upregulation of CD40--CD40 ligand system in patients with diabetes mellitus.Clinica chimica acta; international journal of clinical chemistry, 339 1-2
P. Lapchak, M. Melter, S. Pal, J. Flaxenburg, C. Geehan, M. Frank, D. Mukhopadhyay, D. Briscoe (2004)
CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island.American journal of physiology. Renal physiology, 287 3
C. Kooten, J. Banchereau (2000)
CD40‐CD40 ligandJournal of Leukocyte Biology, 67
J. Myśliwiec, Magdalena Okłota, A. Nikołajuk, D. Waligórski, M. Górska (2007)
Serum CD40/CD40L System in Graves' Disease and Hashimoto's Thyroiditis Related to Soluble Fas, FasL and Humoral Markers of Autoimmune ResponseImmunological Investigations, 36
C. Larsen, D. Alexander, D. Hollenbaugh, E. Elwood, S. Ritchie, A. Aruffo, R. Hendrix, T. Pearson (1996)
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.Transplantation, 61 1
U. Schönbeck, P. Libby (2001)
CD40 Signaling and Plaque InstabilityCirculation Research: Journal of the American Heart Association, 89
M. Poggi, J. Jager, O. Paulmyer‐Lacroix, F. Peiretti, T. Grémeaux, M. Verdier, M. Grino, A. Stépanian, Simon Msika, R. Burcelin, D. Prost, J. Tanti, M. Alessi (2009)
The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytesDiabetologia, 52
K. Komura, M. Fujimoto, T. Matsushita, K. Yanaba, M. Kodera, Ayako Kawasuji, M. Hasegawa, K. Takehara, S. Sato (2007)
Increased serum soluble CD40 levels in patients with systemic sclerosis.The Journal of rheumatology, 34 2
S. Smola‐Hess, Rolf Schnitzler, D. Hadaschik, H. Smola, C. Mauch, T. Krieg, H. Pfister (2001)
CD40L induces matrix-metalloproteinase-9 but not tissue inhibitor of metalloproteinases-1 in cervical carcinoma cells: imbalance between NF-kappaB and STAT3 activation.Experimental cell research, 267 2
J. Naismith, S. Sprang (1998)
Modularity in the TNF-receptor family.Trends in biochemical sciences, 23 2
Silva Hanissian, R. Geha (1997)
Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells.Immunity, 6 4
M. Luomala, Hannu Päivä, R. Laaksonen, K. Thelen, D. Lütjohann, N. Peltonen, T. Lehtimäki (2006)
Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemiaScandinavian Cardiovascular Journal, 40
A. Grammer, J. Swantek, R. McFarland, Y. Miura, T. Geppert, P. Lipsky (1998)
TNF receptor-associated factor-3 signaling mediates activation of p38 and Jun N-terminal kinase, cytokine secretion, and Ig production following ligation of CD40 on human B cells.Journal of immunology, 161 3
M. Tone, Y. Tone, P. Fairchild, M. Wykes, H. Waldmann (2001)
Regulation of CD40 function by its isoforms generated through alternative splicing.Proceedings of the National Academy of Sciences of the United States of America, 98 4
R. Black (2002)
Tumor necrosis factor-alpha converting enzyme.The international journal of biochemistry & cell biology, 34 1
V. Nguyen, E. Benveniste (2002)
Critical Role of Tumor Necrosis Factor-α and NF-κB in Interferon-γ-induced CD40 Expression in Microglia/Macrophages*The Journal of Biological Chemistry, 277
J. Pound, A. Challa, M. Holder, R. Armitage, Steven Dower, W. Fanslow, Hitoshi Kikutani, Staffan Paulie, Christopher Gregory, John Gordon (1999)
Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells.International immunology, 11 1
sCD40 has an antagonistic role to CD40/CD40L interaction: it preserves the ability of binding to CD40L but does not activate the CD40/CD40L pathway (working as a blocker of the CD40/CD40L pathway)
G. Mierlo, A. Boer, J. Medema, E. Voort, M. Fransen, R. Offringa, C. Melief, R. Toes (2002)
CD40 stimulation leads to effective therapy of CD40− tumors through induction of strong systemic cytotoxic T lymphocyte immunityProceedings of the National Academy of Sciences of the United States of America, 99
(2003)
Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction
C. Salmaso, D. Olive, G. Pesce, M. Bagnasco (2002)
Costimulatory Molecules and Autoimmune Thyroid DiseasesAutoimmunity, 35
C. Karp, A. Boxel-Dezaire, A. Byrnes, L. Nagelkerken (2001)
Interferon-beta in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10?Current opinion in neurology, 14 3
C. Reyes-Moreno, J. Girouard, R. Lapointe, A. Darveau, W. Mourad (2004)
CD40/CD40 Homodimers Are Required for CD40-induced Phosphatidylinositol 3-Kinase-dependent Expression of B7.2 by Human B Lymphocytes*Journal of Biological Chemistry, 279
G. Bonizzi, M. Karin (2004)
The two NF-kappaB activation pathways and their role in innate and adaptive immunity.Trends in immunology, 25 6
M. Munroe, G. Bishop (2006)
A Costimulatory Function for T Cell CD40
Pluvinet (2004)
RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cellsBlood, 104
Harald Wajant, F. Henkler, P. Scheurich (2001)
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.Cellular signalling, 13 6
A. Chatzigeorgiou, P. Lembessis, C Mylona-Karagianni, E. Tsouvalas, E. Diamanti-Kandarakis, E. Kamper (2009)
CD40 expression and its association with low-grade inflammation in a Greek population of type 1 diabetic juveniles: evidence for differences in CD40 mRNA isoforms expressed by peripheral blood mononuclear cells.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 118 1
N. Lee, Soo Lee (2002)
Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs).Journal of biochemistry and molecular biology, 35 1
J. Laman, B. Hart, H. Brok, M. Meurs, M. Schellekens, A. Kasran, L. Boon, J. Bauer, M. Boer, J. Ceuppens (2002)
Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12)European Journal of Immunology, 32
J. Laman, B. Smet, Arjen Schoneveld, M. Meurs (1997)
CD40-CD40L interactions in atherosclerosis.Immunology today, 18 6
B. Balasa, T. Krahl, G. Patstone, Jae Lee, R. Tisch, H. Mcdevitt, Nora Sarvetnick (1997)
CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.Journal of immunology, 159 9
Sten Braesch-Andersen, Staffan Paulie, H. Koho, H. Nika, P. Aspenström, P. Perlmann (1989)
Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40.Journal of immunology, 142 2
A. Davidson, Xiaobo Wang, M. Mihara, M. Ramanujam, Wei-qing Huang, L. Schiffer, Jayashree Sinha (2003)
Co‐Stimulatory Blockade in the Treatment of Murine Systemic Lupus Erythematosus (SLE)Annals of the New York Academy of Sciences, 987
G. Deng, Lixin Zheng, F. Chan, M. Lenardo (2005)
Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptorsNature Medicine, 11
C. Reyes-Moreno, Ehssan Sharif-Askari, J. Girouard, C. Léveillé, Malek Jundi, A. Akoum, R. Lapointe, A. Darveau, W. Mourad (2007)
Requirement of Oxidation-dependent CD40 Homodimers for CD154/CD40 Bidirectional Signaling*Journal of Biological Chemistry, 282
H. Qin, Cynthia Wilson, Sun Lee, Xueyan Zhao, E. Benveniste (2005)
LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia.Blood, 106 9
Meenu Sharma, M. Moraes, F. Zavala, C. Pontoux, M. Papiernik, M. Papiernik (1998)
Induction and inhibition of CD40-CD40 ligand interactions: a new strategy underlying host-virus relationships.Journal of immunology, 161 10
A. Eliopoulos, Maria Stack, C. Dawson, K. Kaye, Liz Hodgkin, S. Sihota, M. Rowe, L. Young (1997)
Epstein – Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factorsOncogene, 14
Peder Buchhave, S. Janciauskiene, H. Zetterberg, K. Blennow, L. Minthon, O. Hansson (2009)
Elevated plasma levels of soluble CD40 in incipient Alzheimer's diseaseNeuroscience Letters, 450
A. Aljada, J. Friedman, H. Ghanim, P. Mohanty, D. Hofmeyer, A. Chaudhuri, P. Dandona (2006)
Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects.Metabolism: clinical and experimental, 55 9
S. Beinke, S. Ley (2004)
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology.The Biochemical journal, 382 Pt 2
Cd154-activated Endothelial Cells Rnai-mediated Silencing of Cd40 Prevents Leukocyte Adhesion On
K. Kotowicz, G. Dixon, N. Klein, Mark Peters, R. Callard (2000)
Biological function of CD40 on human endothelial cells: costimulation with CD40 ligand and interleukin‐4 selectively induces expression of vascular cell adhesion molecule‐1 and P‐selectin resulting in preferential adhesion of lymphocytesImmunology, 100
M. Säemann, P. Kelemen, M. Zeyda, G. Böhmig, G. Staffler, G. Zlabinger (2002)
CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited.Transplantation proceedings, 34 5
J. Myśliwiec, D. Waligórski, A. Nikołajuk, M. Górska (2007)
Soluble CD40 and its ligand CD154 in patients with Graves' ophthalmopathy during combined therapy with corticosteroids and teleradiotherapy.Advances in medical sciences, 52
U. Schönbeck, G. Sukhova, K. Shimizu, F. Mach, P. Libby (2000)
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice.Proceedings of the National Academy of Sciences of the United States of America, 97 13
V. Henn, J. Slupsky, M. Gräfe, I. Anagnostopoulos, R. Förster, G. Müller‐Berghaus, R. Kroczek (1998)
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cellsNature, 391
K. Karmann, C. Hughes, J. Schechner, W. Fanslow, J. Pober (1995)
CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.Proceedings of the National Academy of Sciences of the United States of America, 92 10
F. Chiarelli, C. Giannini, Alberto Verrotti, Andrea Mezzetti, A. Mohn (2008)
Increased concentrations of soluble CD40 ligand may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuriaDiabetes/Metabolism Research and Reviews, 24
F. Mach, U. Schönbeck, G. Sukhova, T. Bourcier, J. Bonnefoy, J. Pober, P. Libby (1997)
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America, 94 5
G. Bishop, Carissa Moore, P. Xie, L. Stunz, Zachary Kraus (2007)
TRAF proteins in CD40 signaling.Advances in experimental medicine and biology, 597
T. Masunaga, K. Yamashita, Hideyasu Sakihama, Taku Hashimoto, Nan Hua, A. Imai, M. Inobe, T. Miyazaki, S. Todo, T. Uede (2005)
Dimeric but not Monomeric Soluble CD40 Prolongs Allograft Survival and Generates Regulatory T Cells that Inhibit CTL FunctionTransplantation, 80
E. Battaglia, L. Biancone, A. Resegotti, G. Emanuelli, G. Fronda, G. Camussi (1999)
Expression of CD40 and its ligand, CD40L, in intestinal lesions of Crohn's diseaseAmerican Journal of Gastroenterology, 94
H. Qin, Cynthia Wilson, Sun Lee, E. Benveniste (2006)
IFN‐β‐induced SOCS‐1 negatively regulates CD40 gene expression in macrophages and microgliaThe FASEB Journal, 20
E. Lutgens, M. Daemen (2002)
CD40-CD40L interactions in atherosclerosis.Trends in cardiovascular medicine, 12 1
sCD40 is excreted by the kidneys and thus is present both in plasma and urine
C. Caux, C. Massacrier, atrice Vanbervliet, B. Dubois, C. Kooten, I. Durand, J. Banchereau (1994)
Activation of human dendritic cells through CD40 cross-linkingThe Journal of Experimental Medicine, 180
R. French, H. Chan, A. Tutt, M. Glennie (1999)
CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell helpNature Medicine, 5
K. Macdonald, Y. Nishioka, P. Lipsky, Ranjeny Thomas (1997)
Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.The Journal of clinical investigation, 100 9
K. Gerritse, J. Laman, R. Noelle, A. Aruffo, J. Ledbetter, W. Boersma, E. Claassen (1996)
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America, 93 6
U. Thienel, J. Loike, M. Yellin (1999)
CD154 (CD40L) induces human endothelial cell chemokine production and migration of leukocyte subsets.Cellular immunology, 198 2
R. Siegel, J. Frederiksen, D. Zacharias, F. Chan, Michele Johnson, D. Lynch, R. Tsien, M. Lenardo (2000)
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.Science, 288 5475
M. Tone, Y. Tone, J. Babik, Chun-Yen Lin, H. Waldmann (2002)
The role of Sp1 and NF-kappa B in regulating CD40 gene expression.The Journal of biological chemistry, 277 11
V. Nguyen, E. Benveniste (2000)
Involvement of STAT-1 and Ets Family Members in Interferon-γ Induction of CD40 Transcription in Microglia/Macrophages*The Journal of Biological Chemistry, 275
S. Chakrabarti, Price Blair, J. Freedman (2007)
CD40-40L Signaling in Vascular Inflammation*Journal of Biological Chemistry, 282
G. Bonizzi, M. Karin (2004)
The two NF-κB activation pathways and their role in innate and adaptive immunityTrends in Immunology, 25
H. Schmilovitz-Weiss, A. Belinki, O. Pappo, J. Sulkes, E. Melzer, E. Kaganovski, B. Kfir, R. Tur-kaspa, T. Klein, Z. Ben‐Ari (2004)
Role of circulating soluble CD40 as an apoptotic marker in liver diseaseApoptosis, 9
N. Kenyon, M. Chatzipetrou, M. Masetti, A. Ranuncoli, Maria Oliveira, Joseph Wagner, A. Kirk, D. Harlan, L. Burkly, C. Ricordi (1999)
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.Proceedings of the National Academy of Sciences of the United States of America, 96 14
Schwabe Rf, H. Engelmann, S. Hess, H. Fricke (1999)
Soluble CD40 in the serum of healthy donors, patients with chronic renal failure, haemodialysis and chronic ambulatory peritoneal dialysis (CAPD) patientsClinical & Experimental Immunology, 117
J. Purkerson, D. Parker (1998)
Differential coupling of membrane Ig and CD40 to the extracellularly regulated kinase signaling pathway.Journal of immunology, 160 5
Hong-hui Shen, Hong-yan Sun, Jing-min Zhao, J. Hou, B. Bai, Yan Hu, W. Kong, P. Mao (2008)
[Level and clinical significance of soluble CD40 in patients with chronic hepatitis B].Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 22 5
D. Eshel, A. Toporik, Tali Efrati, S. Nakav, Aviva Chen, A. Douvdevani (2008)
Characterization of natural human antagonistic soluble CD40 isoforms produced through alternative splicing.Molecular immunology, 46 2
H. Jabara, R. Buckley, J. Roberts, G. Lefranc, J. Loiselet, G. Khalil, R. Geha (1998)
Role of JAK3 in CD40-mediated signaling.Blood, 92 7
Jun-ichiro Inoue, Takaomi Ishida, Nobuo Tsukamoto, N. Kobayashi, A. Naito, S. Azuma, Tadashi Yamamoto (2000)
Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling.Experimental cell research, 254 1
M. Tsuzuki, I. Morishima, T. Yoshida, Yuzo Hayashi, Manabu Miura, Toshihisa Hirai, T. Asai, Y. Numaguchi, T. Sone, H. Matsui, K. Okumura, T. Murohara (2005)
Inverse correlation between soluble CD40 ligand and soluble CD40 is absent in patients with unstable anginaHeart and Vessels, 20
C. Dallman, Peter Johnson, Graham Packham (2004)
Differential regulation of cell survival by CD40Apoptosis, 8
H. Chai, Shaoyu Yan, Hao Wang, Rongxin Zhang, P. Lin, Q. Yao, Changyi Chen (2006)
CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells.Surgery, 140 2
Juswinder Singh, E. Garber, H. Vlijmen, M. Karpusas, Y. Hsu, Zhongli Zheng, David Thomas, J. Naismith (1998)
The role of polar interactions in the molecular recognition of CD40L with its receptor CD40Protein Science, 7
F. Santilli, S. Basili, P. Ferroni, G. Davı̀ (2007)
CD40/CD40L system and vascular diseaseInternal and Emergency Medicine, 2
H. Qin, Cynthia Wilson, Sun Lee, Xueyan Zhao, E. Benveniste (2005)
LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microgliaBlood, 106
U. Schönbeck, F. Mach, G. Sukhova, Elizabeth Atkinson, E. Levesque, M. Herman, P. Graber, P. Basset, P. Libby (1999)
Expression of Stromelysin-3 in Atherosclerotic Lesions: Regulation via CD40–CD40 Ligand Signaling In Vitro and In VivoThe Journal of Experimental Medicine, 189
T. Town, Jun Tan, M. Mullan (2001)
CD40 signaling and Alzheimer's disease pathogenesisNeurochemistry International, 39
C. Contin, L. Couzi, J. Moreau, J. Déchanet-Merville, P. Merville (2004)
[Immune dysfuntion of uremic patients: potential role for the soluble form of CD40].Nephrologie, 25 4
CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B‐cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
BioFactors – Wiley
Published: Nov 1, 2009
Keywords: ; ; ;
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