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CD40/CD40L signaling and its implication in health and disease

CD40/CD40L signaling and its implication in health and disease CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B‐cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases. © 2009 International Union of Biochemistry and Molecular Biology, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioFactors Wiley

CD40/CD40L signaling and its implication in health and disease

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References (149)

Publisher
Wiley
Copyright
Copyright © 2009 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0951-6433
eISSN
1872-8081
DOI
10.1002/biof.62
pmid
19904719
Publisher site
See Article on Publisher Site

Abstract

CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B‐cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases. © 2009 International Union of Biochemistry and Molecular Biology, Inc.

Journal

BioFactorsWiley

Published: Nov 1, 2009

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