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Functional properties of regenerating skeletal muscle following LIF administration

Functional properties of regenerating skeletal muscle following LIF administration We tested the hypothesis that periodic systemic administration of the myogenic cytokine leukemia inhibitory factor (LIF) enhances the functional recovery of regenerating skeletal muscle following bupivacaine‐induced degeneration. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post‐injury. The results do not support exogenous administration of LIF as a treatment for acute muscle injury, but a more frequent dosing regimen should be tested. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1586–1588, 2000 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Muscle and Nerve Wiley

Functional properties of regenerating skeletal muscle following LIF administration

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References (20)

Publisher
Wiley
Copyright
Copyright © 2000 John Wiley & Sons, Inc.
ISSN
0148-639X
eISSN
1097-4598
DOI
10.1002/1097-4598(200010)23:10<1586::AID-MUS17>3.0.CO;2-A
Publisher site
See Article on Publisher Site

Abstract

We tested the hypothesis that periodic systemic administration of the myogenic cytokine leukemia inhibitory factor (LIF) enhances the functional recovery of regenerating skeletal muscle following bupivacaine‐induced degeneration. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post‐injury. The results do not support exogenous administration of LIF as a treatment for acute muscle injury, but a more frequent dosing regimen should be tested. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1586–1588, 2000

Journal

Muscle and NerveWiley

Published: Oct 1, 2000

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