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Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC

Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or... natants from lipopolysaccharide-stimulated blood mononuclear cells (BMNCs) isolated from untrained persons 2 h after bicycle (ll), increased in vitro production of IL-l was found in trained persons after bicycle to exhaustion (17). Increased endogenous pyrogen activity in plasma after concentric was shown several years ago (4). In this study, we investigated the effects of bicycle on plasma levels of IL-la, IL-l& IL-6, TNF-ar the presence of pre-mRNA for these cytokines in BMNCs. MATERIALS METHODS induces numerous changes in the immune system (2, 15, 20). It has been clearly documented that physical , including eccentric muscle contractions, induces an increase in the levels of monokines. Increased interleukin (IL) -1p levels in muscle tissue up to 5 days after eccentric muscle work were found (3). IL-l activity increased after eccentric in plasma from untrained subjects (9). After long-distance running, increased IL-6 levels in plasma were found (19, 25), others have found increased plasma tumor necrosis factor-a (TNF-cu) levels (7). The primary mediators of the acute-phase protein synthesis are IL-l, of IL-6, TNF -CY, which IL-l TNF-cu are thought to cause muscle proteolysis (8). In support of this theory, it has been shown that injection of IL-l or TNF-cu into animals http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC

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Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

natants from lipopolysaccharide-stimulated blood mononuclear cells (BMNCs) isolated from untrained persons 2 h after bicycle (ll), increased in vitro production of IL-l was found in trained persons after bicycle to exhaustion (17). Increased endogenous pyrogen activity in plasma after concentric was shown several years ago (4). In this study, we investigated the effects of bicycle on plasma levels of IL-la, IL-l& IL-6, TNF-ar the presence of pre-mRNA for these cytokines in BMNCs. MATERIALS METHODS induces numerous changes in the immune system (2, 15, 20). It has been clearly documented that physical , including eccentric muscle contractions, induces an increase in the levels of monokines. Increased interleukin (IL) -1p levels in muscle tissue up to 5 days after eccentric muscle work were found (3). IL-l activity increased after eccentric in plasma from untrained subjects (9). After long-distance running, increased IL-6 levels in plasma were found (19, 25), others have found increased plasma tumor necrosis factor-a (TNF-cu) levels (7). The primary mediators of the acute-phase protein synthesis are IL-l, of IL-6, TNF -CY, which IL-l TNF-cu are thought to cause muscle proteolysis (8). In support of this theory, it has been shown that injection of IL-l or TNF-cu into animals

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Jul 1, 1994

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