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Evasion of the human innate immune system by dengue virus

Evasion of the human innate immune system by dengue virus Dengue virus is a worldwide health problem, with billions of people at risk annually. Dengue virus causes a spectrum of diseases, namely dengue fever, dengue hemorrhagic fever and dengue shock syndrome with the latter two being linked to death. Understanding how dengue is able to evade the immune system and cause enhanced severity of disease is the main topics of interest in the Fernandez-Sesma laboratory at Mount Sinai School of Medicine. Using primary human immune cells, our group investigates the contribution of dengue virus-specific proteins to the evasion of innate immunity by this virus and the host factors that the virus interacts with in order to evade immune recognition and to establish infection in humans. Here, we review recent findings from our group as well as published data from other groups regarding immune modulation by dengue virus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Immunologic Research Springer Journals

Evasion of the human innate immune system by dengue virus

Immunologic Research , Volume 54 (3) – May 9, 2012

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References (66)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Internal Medicine; Immunology; Medicine/Public Health, general; Allergology
ISSN
0257-277X
eISSN
1559-0755
DOI
10.1007/s12026-012-8334-2
pmid
22569913
Publisher site
See Article on Publisher Site

Abstract

Dengue virus is a worldwide health problem, with billions of people at risk annually. Dengue virus causes a spectrum of diseases, namely dengue fever, dengue hemorrhagic fever and dengue shock syndrome with the latter two being linked to death. Understanding how dengue is able to evade the immune system and cause enhanced severity of disease is the main topics of interest in the Fernandez-Sesma laboratory at Mount Sinai School of Medicine. Using primary human immune cells, our group investigates the contribution of dengue virus-specific proteins to the evasion of innate immunity by this virus and the host factors that the virus interacts with in order to evade immune recognition and to establish infection in humans. Here, we review recent findings from our group as well as published data from other groups regarding immune modulation by dengue virus.

Journal

Immunologic ResearchSpringer Journals

Published: May 9, 2012

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