Access the full text.
Sign up today, get DeepDyve free for 14 days.
N. Sasaki, T. Ikawa, A. Fukuda (1991)
Orientation of mineral in bovine bone and the anisotropic mechanical properties of plexiform bone.Journal of biomechanics, 24 1
Christopher Siedlecki, R. Marchant (1998)
Atomic force microscopy for characterization of the biomaterial interface.Biomaterials, 19 4-5
A. Arsenault (1989)
A comparative electron microscopic study of apatite crystals in collagen fibrils of rat bone, dentin and calcified turkey leg tendons.Bone and mineral, 6 2
E. Katz (1969)
The kinetics of mineralization in vitro. I. The nucleation properties of 640-Å collagen at 25°Biochimica et Biophysica Acta, 194
M. McKee, A. Nanci, W. Landis, Y. Gotoh, L. Gerstenfeld, M. Glimcher (1991)
Effects of fixation and demineralization on the retention of bone phosphoprotein and other matrix components as evaluated by biochemical analyses and quantitative immunocytochemistryJournal of Bone and Mineral Research, 6
M. Glimcher (1998)
The Nature of the Mineral Phase in Bone: Biological and Clinical Implications
Robert Robinson (1952)
An electron-microscopic study of the crystalline inorganic component of bone and its relationship to the organic matrix.The Journal of bone and joint surgery. American volume, 34-A 2
W. Landis, K. Hodgens, M. Song, J. Arena, Sumiko Kiyonaga, M. Marko, Cameron Owen, B. McEwen (1996)
Mineralization of collagen may occur on fibril surfaces: evidence from conventional and high-voltage electron microscopy and three-dimensional imaging.Journal of structural biology, 117 1
Arsenault Arsenault (1988)
Crystal‐collagen relationships in calcified turkey leg tendons visualized by selected‐area dark field electron microscopyCalcif Tissue Int, 43
C. Rey, H. Kim, L. Gerstenfeld, M. Glimcher (1996)
Characterization of the apatite crystals of bone and their maturation in osteoblast cell culture: comparison with native bone crystals.Connective tissue research, 35 1-4
R. Wiesendanger (1994)
Scanning Probe Microscopy and Spectroscopy: Contents
M. Gale, M. Pollanen, P. Markiewicz, M. Goh (1995)
Sequential assembly of collagen revealed by atomic force microscopy.Biophysical journal, 68 5
Y. Bouligand, M. Giraud‐Guille (1985)
Spatial Organization of Collagen Fibrils in Skeletal Tissues: Analogies with Liquid Crystals
(1995)
Maturation of poorly crystalline apatites. Chemical and structural aspects in vivo and in vitro
G. Herring (1972)
CHAPTER 5 – The Organic Matrix of Bone
Smith Smith, Shoukri Shoukri (2000)
Diagnosis of osteoporosis (In process citation)Clin Cornerstone, 2
D. Ulrich, T. Hildebrand, B. Rietbergen, R. Müller, P. Rüegsegger (1997)
The quality of trabecular bone evaluated with micro-computed tomography, FEA and mechanical testing.Studies in health technology and informatics, 40
(1968)
The organization and structure of bone, and the mechanism of calcification
Manfred Jaschke, H. Butt (1995)
Height calibration of optical lever atomic force microscopes by simple laser interferometryReview of Scientific Instruments, 66
L. Siperko, W. Landis (1994)
Atomic force microscopic determination of substrate effects on the structure of deposited biomineral phosphatesAnalyst, 119
Elton Katz, Shu Li (1973)
The intermolecular space of reconstituted collagen fibrils.Journal of molecular biology, 73 3
C. Johnston, C. Slemenda (1992)
Diagnosis of OsteoporosisSouthern Medical Journal, 85
S. Lipson, J. Katz (1984)
The relationship between elastic properties and microstructure of bovine cortical bone.Journal of biomechanics, 17 4
A. Hodge (1989)
Molecular models illustrating the possible distributions of 'holes' in simple systematically staggered arrays of type I collagen molecules in native-type fibrils.Connective tissue research, 21 1-4
D. Wilson, K. Kump, S. Eppell, R. Marchant (1995)
Morphological restoration of atomic force microscopy imagesLangmuir, 11
M. Glimcher (1984)
Recent studies of the mineral phase in bone and its possible linkage to the organic matrix by protein-bound phosphate bonds.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 304 1121
Deepak Vashishth, J. Behiri, William Bonfield (1997)
Crack growth resistance in cortical bone: concept of microcrack toughening.Journal of biomechanics, 30 8
H. Wagner, Stephen Weiner (1992)
On the relationship between the microstructure of bone and its mechanical stiffness.Journal of biomechanics, 25 11
Hyun‐Man Kim, C. Rey, M. Glimcher (1995)
Isolation of calcium‐phosphate crystals of bone by non‐aqueous methods at low temperatureJournal of Bone and Mineral Research, 10
J. Villarrubia (1997)
Algorithms for Scanned Probe Microscope Image Simulation, Surface Reconstruction, and Tip EstimationJournal of Research of the National Institute of Standards and Technology, 102
Kim Kim, Glimcher Glimcher (1996)
X‐ray diffraction, electron microscopy and Fourier transform infrared spectroscopy of apatite crystals isolated from chiken and bovine calcified cartilageCalcif Tissue Int, 59
A. Miller (1984)
Collagen: the organic matrix of bone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 304 1121
M.D Grynpas, L. Bonar, M. Glimcher (1984)
X-ray diffraction radial distribution function studies on bone mineral and synthetic calcium phosphatesJournal of Materials Science, 19
A. Hodge, J. Petruska (1963)
Recent studies with the electron microscope on ordered aggregates of the tropocollagen macromolecule
M. Kay, R. Young, A. Posner (1964)
Crystal Structure of HydroxyapatiteNature, 204
S. White, D. Hulmes, Andrew Miller, P. Timmins (1977)
Collagen–mineral axial relationship in calcified turkey leg tendon by X-ray and neutron diffractionNature, 266
E. Katz, S. Li (1972)
The molecular packing of collagen in mineralized and non-mineralized tissues.Biochemical and biophysical research communications, 46 3
W. Landis, K. Hodgens, J. Arena, M. Song, B. McEwen (1996)
Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomographyMicroscopy Research and Technique, 33
Vivi Ziv, S. Weiner (1994)
Bone crystal sizes: a comparison of transmission electron microscopic and X-ray diffraction line width broadening techniques.Connective tissue research, 30 3
Stephen Weiner, Ha Lowenstam (1986)
Organization of extracellularly mineralized tissues: a comparative study of biological crystal growth.CRC critical reviews in biochemistry, 20 4
U. Akiva, H. Wagner, S. Weiner (1998)
Modelling the three-dimensional elastic constants of parallel-fibred and lamellar boneJournal of Materials Science, 33
W. Landis, M. Song, A. Leith, L. McEwen, B. McEwen (1993)
Mineral and organic matrix interaction in normally calcifying tendon visualized in three dimensions by high-voltage electron microscopic tomography and graphic image reconstruction.Journal of structural biology, 110 1
C. Berthet‐Colominas, A. Miller, S. White (1979)
Structural study of the calcifying collagen in turkey leg tendons.Journal of molecular biology, 134 3
C. Bustamante, D. Keller (1995)
Scanning Force Microscopy in BiologyPhysics Today, 48
Weiner Weiner, Price Price (1986)
Disaggregation of bone into crystalsCalcif Tissue Int, 39
S. Nielsen (2000)
The Fallacy of BMD: A Critical Review of the Diagnostic Use of Dual X-ray AbsorptiometryClinical Rheumatology, 19
K. Onuma, A. Ito (1998)
Cluster Growth Model for HydroxyapatiteChemistry of Materials, 10
Elton Katz, Shu-Tung Li (1973)
Structure and function of bone collagen fibrils.Journal of molecular biology, 80 1
J. Eastoe (1956)
THE ORGANIC MATRIX OF BONE
W. Bonfield, C. Li (1967)
Anisotropy of Nonelastic Flow in BoneJournal of Applied Physics, 38
J. Blair, L. Sorensen, M. Arnsdorf, R. Lal (1995)
The application of atomic force microscopy for the detection of microcrystals in synovial fluid from patients with recurrent synovitis.Seminars in arthritis and rheumatism, 24 5
Nielsen Nielsen (2000)
The fallacy of BMD. A critical review of the diagnostic use of dual X‐ray absorptiometry (In process citation)Clin Rheumatol, 19
A. Ascenzi, P. Baschieri, A. Benvenuti (1994)
The torsional properties of single selected osteons.Journal of biomechanics, 27 7
J. Moradian-Oldak, S. Weiner, L. Addadi, W. Landis, W. Traub (1991)
Electron imaging and diffraction study of individual crystals of bone, mineralized tendon and synthetic carbonate apatite.Connective tissue research, 25 3-4
Bonar Bonar, Roufosse Roufosse, Sabine Sabine, Grynpas Grynpas, Glimcher Glimcher (1983)
X‐ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated boneCalcif Tissue Unt, 35
K. Onuma, A. Ito, T. Tateishi, T. Kameyama (1995)
Growth kinetics of hydroxyapatite crystal revealed by atomic force microscopyJournal of Crystal Growth, 154
The inorganic phase of bone is comprised primarily of very small mineralites. The size and shape of these mineralites play fundamental roles in maintaining ionic homeostasis and in the biomechanical function of bone. Using atomic force microscopy, we have obtained direct three‐dimensional visual evidence of the size and shape of native protein‐free mineralites isolated from mature bovine bone. Approximately 98% of the mineralites are less than 2 nm thick displaying a plate‐like habit. Distributions of both thickness and width show single peaks. The distribution of lengths may be multimodal with distinct peaks separated by ∼6 nm. Application of our results is expected to be of use in the design of novel orthopaedic biomaterials. In addition, they provide more accurate inputs to molecular‐scale models aimed at predicting the physiological and mechanical behavior of bone. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Journal of Orthopaedic Research – Wiley
Published: Nov 1, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.