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H. Wachter, D. Fuchs, A. Hausen, C. Huber, O. Knosp, G. Reibnegger, T. Spira (1983)
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Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.Science, 216 4544
Be Huber, Mathias Merkenschlager, Claus Gattringer, Ivor Royston, Ulrich Fink, Herbert Braunsteiner (1982)
Human autologous mixed lymphocyte reactivity is primarily specific for xenoprotein determinants adsorbed to antigen-presenting cells during rosette formation with sheep erythrocytesThe Journal of Experimental Medicine, 155
G. Reibnegger, V. Boonpucknavig, D. Fuchs, A. Hausen, E. Schmutzhard, H. Wachter (1984)
Urinary neopterin is elevated in patients with malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene, 78 4
(1983)
Neopterin (N) as a new biochemical marker for diagnosis of ailograft rejection: experience based upon evaluation of 100 consecutive cases
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Neopterin evaluation in patients with pulmonary tuberculosis
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INTERFERON-~. STIMULATES NEOPTERIN RELEASE FROM MACROPHAGES
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Erh6hte Ausscheidung von Neopterin im Harn yon Patienten mit malignen Tumoren und mit Viruserkrankungen
C. Huber, D. Fuchs, A. Hausen, R. Margreiter, G. Reibnegger, M. Spielberger, H. Wachter (1983)
Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants.Journal of immunology, 130 3
C. Huber, U. Fink, W. Leibold, F. Schmalzl, P. Peterson, L. Klareskog, H. Braunsteiner (1981)
The role of adherent HLA-DR+ mononuclear cells in autologous and allogeneic MLR.Journal of immunology, 127 2
D. Niederwieser, C. Huber, A. Gratwohl, P. Bannerth, D. Speck, D. Fuchs, A. Hausen, G. Reibnegger, H. Wachter (1983)
NEOPTERIN EXCRETION DURING ALLOGENEIC, SYNGENEIC AND AUTOLOGOUS BONE MARROW TRANSPLANTATION
S. Kaufman, S. Berlow, G. Summer, S. Milstien, J. Schulman, S. Orloff, S. Spielberg, S. Pueschel (1978)
Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria.The New England journal of medicine, 299 13
E. Destefano, R. Friedman, A. Friedman-kien, J. Goedert, D. Henriksen, O. Preble, J. Sonnabend, J. Vilček (1982)
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A. Hausen, D. Fuchs, G. Reibnegger, H. Wachter, D. Egg, R. Günther (1983)
NEOPTERIN AS INDEX FOR ACTIVITY OF DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS NEOPTERIN AS INDEX FOR ACTIVITY OF DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS
A. Hausen, D. Fuchs, K. König, H. Wachter (1982)
Determination of neopterine in human urine by reversed-phase high-performance liquid chromatography.Journal of chromatography, 227 1
Neopterin, a compound derived from GTP, represents a precursor molecule of biopterin that is an essential cofactor in neurotransmitter synthesis. We have recently reported that in vivo as well as in vitro immune responses are accompanied by an increased release of neopterin and that this phenomenon can be used for the biochemical monitoring of diseases accompanied by hyperimmune stimulation. This article deals with the cellular origin and the control of this immune response-associated neopterin release in vitro. Using highly purified or monoclonal cellular reagents we demonstrate that macrophages (M phi) stimulated with supernatants from activated T cells release large amounts of neopterin into culture supernatants. Further experiments involving induction of neopterin release from M phi with various human recombinant interferons (IFNs) or neutralization of the effect of T cell supernatants with various monoclonal anti-IFN antibodies revealed immune IFN as the active principle. It thus appears that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
The Journal of Experimental Medicine – Rockefeller University Press
Published: Jul 1, 1984
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