Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Cilla, E. Perez-trallero, M. Iturriza, A. Carcedo, J. Echeverría (1992)
Maternal-infant transmission of hepatitis C virus infection.The Pediatric infectious disease journal, 11 5
P. Mohan, C. Colvin, C. Glymph, Roma Chandra, D. Kleiner, K. Patel, N. Luban, H. Alter (2007)
Clinical spectrum and histopathologic features of chronic hepatitis C infection in children.The Journal of pediatrics, 150 2
D. Culver, M. Alter, R. Mullan, H. Margolis (2000)
Evaluation of the effectiveness of targeted lookback for HCV infection in the United States—interim resultsTransfusion, 40
L. Seeff, F. Hollinger, H. Alter, E. Wright, Casey Cain, Zelma Buskell, K. Ishak, F. Iber, D. Toro, A. Samanta, R. Koretz, R. Perrillo (2001)
Long‐term mortality and morbidity of transfusion‐associated non‐A, non‐B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative studyHepatology, 33
G. Armstrong, M. Alter, G. Mcquillan, H. Margolis (2000)
The past incidence of hepatitis C virus infection: Implications for the future burden of chronic liver disease in the United StatesHepatology, 31
R. Knodell, K. Ishak, W. Black, Thomas Chen, R. Craig, N. Kaplowitz, T. Kiernan, J. Wollman (1981)
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitisHepatology, 1
M. Jonas (2002)
Children with hepatitis CHepatology, 36
J. Lefrère, R. Girot, F. Lefrère, N. Guillaume, J. Lerable, N. Marrec, F. Bouchardeau, S. Laperche (2004)
Complete or partial seroreversion in immunocompetent individuals after self‐limited HCV infection: consequences for transfusionTransfusion, 44
J. Callum, P. Pinkerton, A. Coovadia, A. Thomson, Frankie Dewsbury (2000)
An evaluation of the process and costs associated with targeted lookbacks for HCV and general notification of transfusion recipientsTransfusion, 40
Miriam Alter, D. Kruszon-Moran, O. Nainan, G. Mcquillan, Fengxiang Gao, L. Moyer, Richard Kaslow, H. Margolis (1999)
The prevalence of hepatitis C virus infection in the United States, 1988 through 1994.The New England journal of medicine, 341 8
L. Seeff, Richard Miller, C. Rabkin, Z. Buskell‐Bales, Kelle Straley-Eason, B. Smoak, Leslye Johnson, Stephen Lee, E. Kaplan (2000)
45-Year Follow-up of Hepatitis C Virus Infection in Healthy Young AdultsAnnals of Internal Medicine, 132
C. Conry-Cantilena, M. Vanraden, J. Gibble, J. Melpolder, A. Shakil, L. Viladomiu, L. Cheung, A. Dibisceglie, J. Hoofnagle, J. Shih, R. Kaslow, P. Ness, H. Alter (1996)
Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection.The New England journal of medicine, 334 26
S. Bowker, L. Smith, R. Rosychuk, J. Preiksaitis (2004)
A review of general hepatitis C virus lookbacks in CanadaVox Sanguinis, 86
E. Vamvakas, R. Goldstein (2002)
Four‐year survival of transfusion recipients identified by hepatitis C lookbackTransfusion, 42
E. Murphy, S. Bryzman, Williams Ae (1999)
Prevalence of hepatitis C virus infection in the United States.The New England journal of medicine, 341 27
M. Alter, H. Margolis (1998)
Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease
W. Fierson, E. Palmer, A. Biglan, J. Flynn, R. Petersen, D. Phelps (1998)
Retinopathy of prematurity guidelines.Ophthalmology, 105 6
N. Halsey, J. Abramson, P. Chesney, M. Fisher, M. Gerber, D. Gromisch, S. Kohl, S. Marcy, D. Murray, G. Overturf, R. Whitley, R. Yogev (1998)
Hepatitis C Virus InfectionPediatrics, 101
A. Davoren, Annette Dillon, J. Power, J. Donnellan, J. Quinn, Joe Willis, Emer Lawlor, J. O’Riordan (2002)
Outcome of an optional HCV screening program for blood transfusion recipients in IrelandTransfusion, 42
J. Langley, S. Squires, D. MacDonald, D. Anderson, K. Peltekian, J. Scott (2001)
Evaluation of the notification of hepatitis C risk to children who received unscreened blood or blood products.Communicable disease and public health, 4 4
Melody Cunningham, E. Macklin, E. Neufeld, A. Cohen (2004)
Complications of beta-thalassemia major in North America.Blood, 104 1
R. Aach, R. Yomtovian, M. Hack (2000)
Neonatal and Pediatric Posttransfusion Hepatitis C: A Look Back and a Look ForwardPediatrics, 105
K. Batts, J. Ludwig (1995)
Chronic hepatitis. An update on terminology and reporting.The American journal of surgical pathology, 19 12
S. Cesaro, M. Petris, F. Rossetti, R. Cusinato, C. Pipan, M. Guido, L. Masiero, G. Botta, G. Meloni, L. Zanesco (1997)
Chronic hepatitis C virus infection after treatment for pediatric malignancy.Blood, 90 3
Mohan (2000)
Clinical spectrum and natural history of hepatitis C (HCV) infection in childrenPediatr Res, 47
N. Heddle, J. Kelton, F. Smaill, K. Foss, J. Everson, Cynthia Janzen, Chris Walker, Mark Jones, Debby Hammons (1997)
A Canadian hospital-based HIV/hepatitis C look-back notification program.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 157 2
S. Castellino, S. Lensing, C. Riely, S. Rai, Rene Davila, R. Hayden, J. Fleckenstein, M. Levstik, Shari Taylor, P. Dean, Sarah Kippenbrock, J. Pope, J. Carr, D. Strickland, M. Hudson (2004)
The epidemiology of chronic hepatitis C infection in survivors of childhood cancer: an update of the St Jude Children's Research Hospital hepatitis C seropositive cohort.Blood, 103 7
M. Aricò, G. Maggiore, E. Silini, F. Bono, C. Viganó, A. Cerino, M. Mondelli (1994)
Hepatitis C virus infection in children treated for acute lymphoblastic leukemia.Blood, 84 9
J. Barrio, M. García-Bengoechea, J. Emparanza, J. Arenas (1998)
[The prevalence of hepatitis C virus infection].Gastroenterologia y hepatologia, 21 5
M. Casiraghi, M. Paschale, L. Romanò, R. Biffi, A. Assi, G. Binelli, A. Zanetti (2004)
Long‐term outcome (35 years) of hepatitis C after acquisition of infection through mini transfusions of blood given at birthHepatology, 39
L. Seeff (2002)
Natural history of chronic hepatitis CHepatology, 36
P. Mohan, R. Chandra, D. Kleiner, N. Luban (2003)
An unusual presentation of perinatally transmitted hepatitis CArchives of Disease in Childhood, 88
H. Alter, L. Seeff (2000)
Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term OutcomeSEMINARS IN LIVER DISEASE, Volume 20
J. Schwimmer, W. Balistreri (2000)
Transmission, Natural History, and Treatment of Hepatitis C Virus Infection in the Pediatric PopulationSEMINARS IN LIVER DISEASE, Volume 20
M. Vogt, F. Mühlbauer, S. Braun, T. Lang, R. Busch, R. Lange, G. Frösner, J. Hess (2004)
Prevalence and Risk Factors of Hepatitis C Infection after Cardiac Surgery in Childhood before and after Blood Donor ScreeningInfection, 32
S. Nelson, M. Jonas (1996)
Hepatitis C infection in children who received extracorporeal membrane oxygenation.Journal of pediatric surgery, 31 5
BACKGROUND: Children transfused with blood and blood products before 1992 are at risk for chronic hepatitis C virus (HCV) infection. To determine the prevalence of HCV infection and risks associated with acquisition of HCV, a single‐institution lookback study was performed. STUDY DESIGN AND METHODS: A total of 5473 infants and children who received transfusions between 1982 and 1992 were identified. A control population of 600 age‐, sex‐, race‐ and zip code–matched children who did not receive transfusions with the same exclusions provided background seroprevalence data. Patients were tested for antibodies to HCV, confirmed with second generation recombinant immunoblot assay (RIBA) and when appropriate quantitative and qualitative HCV RNA by reverse transcription polymerase chain reaction (PCR). Viral persistence was assessed by serial PCR determinations for HCV RNA. RESULTS: Of the 5473 eligible patients, 4726 were locatable and 2758 were tested. Forty‐three children (1.6%) were persistently anti‐HCV enzyme immunoassay (EIA)–positive, confirmed by RIBA; 39 were positive for the presence of HCV RNA. Four cleared their virus as assessed by two negative HCV PCRs 6 months apart. There was a borderline higher number of children with HCV who received fresh whole blood than those who tested HCV‐negative. CONCLUSION: Because HCV infection is generally asymptomatic, children are not identified unless they are specifically tested. We identified, enrolled, tested, and confirmed a new diagnosis of HCV infection in 43 patients. As HCV treatments become increasingly effective, it is important to identify silently infected individuals, particularly when the infection was iatrogenically induced.
Transfusion – Wiley
Published: Apr 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.