Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Linnen, J. Wages, Z. Zhang-Keck, K. Fry, K. Krawczyński, H. Alter, E. Koonin, M. Gallagher, M. Alter, S. Hadziyannis, P. Karayiannis, K. Fung, Y. Nakatsuji, J. Shih, L. Young, M. Piatak, Cameron Hoover, John Fernandez, Stacie Chen, Jian-Chao Zou, T. Morris, K. Hyams, S. Ismay, J. Lifson, G. Hess, S. Foung, H. Thomas, D. Bradley, H. Margolis, J. Kim (1996)
Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible AgentScience, 271
V. Thiers, F. Lunel, D. Valla, N. Azar, C. Fretz, L. Frangeul, J. Huraux, P. Opolon, C. Bréchot (1993)
Post-transfusional anti-HCV-negative non-A non-B hepatitis (II) serological and polymerase chain reaction analysis for hepatitis C and hepatitis B viruses.Journal of hepatology, 18 1
Simons, T. Leary, G. Dawson, T. PILOT-MATIAS, A., Scott Muerhoff, George, G., Schlauder, Suresh, M., Desai, Isa (1995)
Isolation of novel virus-like sequences associated with human hepatitisNature Medicine, 1
R., Boom, '. SOL, C. Jansen, '. WERTHEIM-vAN, Dillen, J., van der, '. Noordaa (1990)
Rapid and simple method for purification of nucleic acidsJournal of Clinical Microbiology, 28
S. Heringlake, Sabine Osterkamp, C. Trautwein, H. Tillmann, Klaus Böker, Scott Muerhoff, Isah Mushahwar, G. Hunsmann, M. Manns (1996)
Association between fulminant hepatic failure and a strain of GBV virus CThe Lancet, 348
V. Schlueter, S. Schmolke, Klaus Stark, Georg Hess, B. Ofenloch-Haehnle, Alfred Engel (1996)
Reverse transcription-PCR detection of hepatitis G virusJournal of Clinical Microbiology, 34
Jin‐Town Wang, F. Tsai, Cha-Ze Lee, Pei-Jer Chen, J. Sheu, Teh‐Hong Wang, Ding-Shinn Chen (1996)
A prospective study of transfusion-transmitted GB virus C infection: similar frequency but different clinical presentation compared with hepatitis C virus.Blood, 88 5
M. Tacke, K. Kiyosawa, K. Stark, V. Schlueter, B. Ofenloch-Haehnle, G. Hess, A. Engel (1997)
Detection of antibodies to a putative hepatitis G virus envelope proteinThe Lancet, 349
M. Bogard, C. Buffet‐Janvresse, J. Cantaloube, P. Biagini, G. Duverlie, S. Castelain, J. Izopet, M. Dubois, C. Defer, I. Lepot, J. Coste, P. Marcellin, M. Martinot-Peignoux, P. Halfon, V. Gérolami, L. Frangeul, J. Pawlotsky, F. Roudot-thoraval, E. Dussaix, P. Loiseau, N. Ravera, P. Lewin, J. Lamoril, J. Lerable, P. Lebon (1997)
GEMHEP multicenter quality control study of PCR detection of GB virus C/hepatitis G virus RNA in serumJournal of Clinical Microbiology, 35
Y. Sugai, H. Nakayama, M. Fukuda, N. Sawada, Takeshi Tanaka, F. Tsuda, H. Okamoto, Y. Miyakawa, M. Mayumi (1997)
Infection with GB virus C in patients with chronic liver diseaseJournal of Medical Virology, 51
N. Azar, D. Valla, F. Lunel, C. Fretz, A. Mallet, D. Jaulmes, J. Fournel, C. Blanc, M. Perrin, C. Amiel (1993)
Post-transfusional anti-HCV-negative, non-A, non-B hepatitis. (I) a prospective clinical and epidemiological survey.Journal of hepatology, 18 1
H. Alter, Y. Nakatsuji, J. Melpolder, J. Wages, R. Wesley, J. Shih, J. Kim (1997)
The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease.The New England journal of medicine, 336 11
F. Lunel, H. Agut, C. Robert, J. Huraux, N. Azar, D. Valla, P. Opolon, C. Fretz, J. Fournel (1991)
Is human herpes virus 6 (HHV‐6) infection associated with posttransfusion hepatitis?Transfusion, 31
G. Dawson, G. Schlauder, T. Pilot-matias, D. Thiele, T. Leary, P. Murphy, J. Rosenblatt, J. Simons, F. Martinson, R. Gutierrez, J. Lentino, C. Pachucki, A. Muerhoff, A. Widell, G. Tegtmeier, S. Desai, I. Mushahwar (1996)
Prevalence studies of GB Virus‐C infection using reverse transcriptase‐polymerase chain reactionJournal of Medical Virology, 50
BACKGROUND: Despite blood donor screening, there are still cases of transfusion‐associated hepatitis. From 1988 to 1992, a prospective study was conducted on the incidence of non‐A, non‐B posttransfusion hepatitis (PTH). STUDY DESIGN: The present investigation was designed to determine if transfusion recipients with PTH who are negative for hepatitis C virus (HCV) were positive for hepatitis G virus (HGV). Patients admitted for surgery who had normal liver tests and no transfusions during the previous 6 months were enrolled. Alanine amino transferase levels were determined monthly for 6 months after surgery and for 1 year in the case of PTH (defined as alanine aminotranferase twice the upper limit of normal in two consecutive assays). HGV RNA and E2 antibodies were tested for in samples from transfusion recipients with or without PTH and from nontransfused patients. RESULTS: Of the 308 blood recipients who were enrolled in the study, 21 (6.8%) had PTH. HGV RNA was detected at the onset of hepatitis in 3 patients with PTH (14%), 2 of whom were also anti‐HCV and HCV RNA positive. One patient developed E2 antibodies without detectable HGV RNA. Three (10.7%) of 28 recipients of an allogeneic transfusion without PTH developed HGV infection. HGV RNA was also found in two nontransfused patients, which suggests nosocomial transmission of HGV. CONCLUSION: Some cases of PTH are associated with HGV; most cases of postoperative HGV infection are not associated with liver abnormalities; and most PTH cases are not associated with known hepatotropic viruses.
Transfusion – Wiley
Published: Nov 12, 1998
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.