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D. CARTEE, DOUGLAS A. YOUNG, MARK D. SLEEPER, JULEEN ZIERATH, WALLBERG-HENRIKSSON, AND JOHN 0. HOLLOSZY of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 CARTEE, GREGORY D., DOUGLAS A. YOUNG, MARK D. SLEEPER, JULEEN ZIERATH, HARRIET WALLBERG-HENRIKSSON, AND JOHN 0. HOLLOSZY. Prolonged increase in insulinstimulated in . Am. J. rats (23, 25). uptake by in the presence of submaximal insulin levels is higher in 1) d, fasted rats -18 h than in resting controls (l4), and 2) in fat-fed rather than in carbohydrate-fed Physiol. 256 (Endocrinol. Metab. 19): E494-E499, 1989.-Exrats -18 h (8). However, these studies ercise can induce short-term increasesin the sensitivity and provided no information regarding whether the enhanced responsiveness skeletal to insulin. of The purpose of this study was to determine the effect of uptake 18 h is due to an additive carbohydrate deprivation on the persistenceof insu- effect of insulin and a persistent -induced inlin sensitivity and responsiveness a bout of .Three crease in permeability, to insulin sensitivity, hours a bout of , epitrochlearis s from to insulin responsiveness, or to a combination carbohydrate-deprived (fat fed) rats showed a 25% greater of these possibilities (8, 14, 23). This question is of increasein
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Apr 1, 1989
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