Access the full text.
Sign up today, get DeepDyve free for 14 days.
Paul Moser (1991)
The effect of putative 5-HT1A receptor antagonists on 8-OH-DPAT-induced hypothermia in rats and mice.European journal of pharmacology, 193 2
(1987)
In vivo and in vitro electrophysiological studies indicate that BMY 7378 is a partial agonist at 5 - HTIA receptors in the rat dorsal raphe nucleus
(1988)
Effects of the 5-hydroxytryptamine receptor antagonist, BMY
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
(1988)
Behavioural and biochemical consequences following activation of 5-HTI-like and GABA receptors in the dorsal raphe
V. Hillegaart (1990)
Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on motor activity in the ratPhysiology & Behavior, 48
(1987)
Attenuation by electroconvulsive shock
P. Hutson, G. Sarna, M. O’Connell, G. Curzon (1989)
Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalisNeuroscience Letters, 100
J. Steinman, S. Carlton, B. Haber, W. Willis (1987)
Differential effects ofp-chlorophenylalanine on indoleamines in brainstem nuclei and spinal cord of rats. I. Biochemical and behavioral analysisBrain Research, 426
P. Hutson, C. Dourish, G. Curzon (1986)
Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors.European journal of pharmacology, 129 3
DOURISH DOURISH, HUTSON HUTSON, CURZON CURZON (1985)
Low doses of the putative serotonin agonist 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin (8‐OH‐DPAT) elicit feeding in the ratPsychopharmacology, 86
LECCI LECCI, BORSINI BORSINI, MANCINELLI MANCINELLI, D'ARANNO D'ARANNO, STASI STASI, VOLTERRA VOLTERRA, MELI MELI (1990)
Effect of serotonergic drugs on stress‐induced hyperthermia (SIH) in miceJ. Neurol Transm. (Gen Sect.), 82
(1988)
Effects of the 5 - hydroxy - tryptamine receptor antagonist , BMY 7378 , on 5 - hydroxytrypt - amine neurotransmission : electrophysiological studies in the rat central nervous system
M. O’Connell, C. Portas, G. Sarna, G. Curzon (1991)
Effect of p‐chlorophenylalanine on release of 5‐hydroxytryptamine from the rat frontal cortex in vivoBritish Journal of Pharmacology, 102
T. Sharp, S. Bramwell, D. Grahame-Smith (1989)
5‐HT1 agonists reduce 5‐hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysisBritish Journal of Pharmacology, 96
C. Dourish, P. Hutson, G. Curzon (1986)
Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nucleiTrends in Pharmacological Sciences, 7
G. Aghajanian, M. Kuhar, R. Roth (1973)
Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine.Brain research, 54
(1991)
Induction of hypothermia in the rat as a model of 5 - HTIA receptor - mediated activity : a pharmacological characterization
J. Henry, K. Yashpal (1984)
Rat brain slicer. A simple device for rapidly obtaining serial slabs of fresh brainBrain Research Bulletin, 13
D. Weissmann-Nanopoulos, Evelyne Mach, J. Magré, Y. Demassey, J. Pujol (1985)
Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brainNeurochemistry International, 7
G. Goodwin, Rosemarie Souza, A. Green (1985)
The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(DI-n-propylamino)tetralin (8-OH-DPAT) A model of presynaptic 5-HT1 functionNeuropharmacology, 24
M. Tricklebank, C. Forler, J. Fozard (1984)
The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.European journal of pharmacology, 106 2
LESCH LESCH, POTEN POTEN, SOHNLE SOHNLE, SCHULTE SCHULTE (1990a)
Pharmacology of the hypothermic response to 5‐HT 1A receptor activation in humansEur. J. Clin. Pharmacol, 39
P. Hutson, T. Donohoe, G. Curzon (1987)
Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion.European journal of pharmacology, 143 2
(1991)
Induction of hypothermia in the rat as a model of 5-HTIA receptor-mediated activity: a pharmacological characterization. Abstr. 5-HT 1991
(1990)
Further investigation of the in vivo antagonist
(1988)
The 5 - HTIA receptor agonist , 8 - OH - DPAT , preferentially activates cell body 5 - HT autorecep - tors in the rat brain in vivo
(1991)
Effect of p-chlorophenylalanine on release of 5-HT from the rat
DOURISH DOURISH, HUTSON HUTSON, CURZON CURZON (1986a)
Para‐chlorophenylalanine prevents feeding induced by the serotonin agonist 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin (8‐OH‐DPAT)Psychopharmacology, 89
D. Bill, M. Knight, E. Forster, Allan Fletcher (1991)
Direct evidence for an important species difference in the mechanism of 8‐OH‐DPAT‐induced hypothermiaBritish Journal of Pharmacology, 103
K. Wozniak, C. Aulakh, J. Hill, D. Murphy (1988)
The effect of 8-OH-DPAT on temperature in the rat and its modification by chronic antidepressant treatmentsPharmacology Biochemistry and Behavior, 30
(1989)
Effects of lesioning central 5 - HT and noradrenaline containing neurones on 8 - OH - DPAT hypothermia mydriasis and hypoacti - vity
K. Martin, D. Heal (1991)
8-OH-DPAT-Induced Hypothermia in Rodents. A Specific Model of 5-HTlA Autoreceptor Function?
The pharmacology of the behavioural and hypothermic responses of rats to 8 - hydroxy - 2 - ( din - propylamino ) - tetralin ( 8 - OH - DPAT )
J. Fozard, P. Saxena (1991)
Serotonin: Molecular Biology, Receptors and Functional Effects
Trevor Sharp, Lisa Backus, S. Hjorth, Steven Bramwell, D. Grahame-Smith (1990)
Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.European journal of pharmacology, 176 3
Takeo Deguchi, A. Sinha, Jack Barchas (1973)
BIOSYNTHESIS OF SEROTONIN IN RAPHÉ NUCLEI OF RAT BRAIN: EFFECT OF p‐CHLOROPHENYLALANINE 1Journal of Neurochemistry, 20
D. Vergé, G. Daval, A. Patey, H. Gozlan, S. Mestikawy, M. Hamon (1985)
Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype.European journal of pharmacology, 113 3
G. Higgins, A. Bradbury, B. Jones, N. Oakley (1988)
Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the ratNeuropharmacology, 27
HJORTH HJORTH (1985)
Hypothermia in the rat induced by the potent serotoninergic agent 8‐OH‐DPAT.J. Neural Transm, 61
A. Adell, G. Sarna, P. Hutson, G. Curzon (1989)
An in vivo dialysis and behavioural study of the release of 5‐HT by p‐chloroamphetamine in reserpine‐treated ratsBritish Journal of Pharmacology, 97
L. Swanson (1984)
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5Trends in Neurosciences, 7
E. Satinoff, S. Kent, H. Li, D. Megirian, J. Tomkowiak (1991)
Circadian rhythms of body temperature and drinking and responses to thermal challenge in rats after PCPAPharmacology Biochemistry and Behavior, 38
( 1 I 990 b ) . 5 - HTlA receptor function in depression : effect of chronic amitriptyline treatment
(1991)
Induction of hypothermia in the rat as a model of 5-HTIA receptor-mediated activity: a pharmacological characterization. Abstr
(1991)
Extracellular 5 - hydroxytryptamine in the raphe nuclei : basal values and the effects of ions and drugs
I. Tohyama, Masakuni Kameyama, H. Kimura (1988)
Quantitative morphometric analysis of two types of serotonin-immunoreactive nerve fibres differentially responding to p-chlorophenylalanine treatment in the rat brainNeuroscience, 26
E. Przegaliński, L. Baran, J. Siwanowicz (1990)
Repeated treatment with imipramine, amitriptyline or electroconvulsive shock does not affect the 8-OH-DPAT-induced increase in food intake in free feeding rats.Polish journal of pharmacology and pharmacy, 42 4
T. Matsuda, T. Kanda, Y. Seong, A. Baba, H. Iwata (1990)
p-chlorophenylalanine attenuates the pituitary-adrenocortical response to 5-HT1A receptor agonists in mice.European journal of pharmacology, 181 3
R. Myers (1975)
Impairment of thermoregulation, food and water intakes in the rat after hypothalamic injections of 5,6-dihydroxytryptamineBrain Research, 94
(1990)
Further investigation of the in vivo antagonist, BMY 7378
Lars-Gunnar Larsson, L. Rényi, S. Ross, Bjorn Svensson, K. Ängeby-Möller (1990)
Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPATNeuropharmacology, 29
S. Hjorth, T. Magnusson (1988)
The 5-HT1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivoNaunyn-Schmiedeberg's Archives of Pharmacology, 338
F. Yocca, D. Hyslop, D. Smith, S. Maayani (1987)
BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes.European journal of pharmacology, 137 2-3
B. Cox, R. Kerwin, T. Lee, C. Pycock (1980)
A dopamine‐5‐hydroxytryptamine link in the hypothalamic pathways which mediate heat loss in the rat.The Journal of Physiology, 303
(1987)
Differential effects of p - chlorophenylalanine on indoleamines in brainstem nuclei and spinal cord of rats I . Biochemical and behavioural analysis
HILLEGART HILLEGART (1991)
Effects of local application of 5‐HT and 8‐OH‐DPAT into the dorsal and median raphe nuclei on core temperature in the ratPsychopharmacology, 103
(1991)
Effect of p - chlorophenylalanine on release of 5 - HT from the rat frontal cortex in vivo
GOODWIN GOODWIN, SOUZA SOUZA, GREEN GREEN (1987b)
Attenuation by electroconvulsive shock and antidepressant drugs of the 5‐HT 1A receptor mediated hypothermia and serotonin syndrome produced by 8‐OH‐DPAT in the ratPsychopharmacology, 91
C. Aulakh, K. Wozniak, M. Haas, J. Hill, J. Zohar, D. Murphy (1988)
Food intake, neuroendocrine and temperature effects of 8-OHDPAT in the rat.European journal of pharmacology, 146 2-3
Y. Chaput, C. Montigny (1988)
Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system.The Journal of pharmacology and experimental therapeutics, 246 1
H. Gozlan, S. Mestikawy, L. Pichat, J. Glowinski, M. Hamon (1983)
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PATNature, 305
(1987)
The pharmacology of the behavioural and hypothermic responses of rats
1 The 5‐HT1A ligand BMY 7378 (8‐(2(4‐(2‐methoxyphenyl)‐1‐piperazinyl)ethyl)8‐azaspirol (4,5)‐decane‐7,9‐dione dihydrochloride, 0.032–2 mg kg−1, s.c.) caused hyperphagia, a response to the activation of presynaptic 5‐HT1A receptors. 2 BMY 7378 (8 mg kg−1, s.c.) and the 5‐HT1A agonist (8‐hydroxy‐2‐(di‐n‐propylamino) tetralin (8‐OH‐DPAT), 0.10 and 0.25 mg kg−1 s.c.) also caused hypothermia. This was inhibited by (−)‐pindolol (1 mg kg−1, i.p.) and not prevented by pretreatments with p‐chlorophenylalanine which grossly depleted 5‐hydroxytryptamine (5‐HT) from terminal regions. The hypothermic effects are explicable by activation of postsynaptic 5‐HT1A receptors. Infusion of BMY 7378 (8–64 μg) into the dorsal raphe was without convincing hypothermic effect. 3 BMY 7378 (8 mg kg−1, s.c.) inhibited another effect of activation of postsynaptic 5‐HT1A receptors, i.e., the induction of components of the 5‐HT syndrome by 8‐OH‐DPAT (0.5, 1.0 mg kg−1, s.c.) which suggests that BMY 7378 has antagonistic as well as agonistic effects at these sites. 4 Partial agonist properties of BMY 7378 at postsynaptic sites were also indicated by doses for hypothermia being much greater than those for hyperphagia i.e., ED50 (hypothermia) > 2 mg kg−1, ED50 (hyperphagia) = 0.010 mg kg−1. This contrasts with the similar ED50 values for both the hypothermic (ED50 = 0.08–0.10 mg kg−1) and hyperphagic (ED50 = 0.06–0.10 mg kg−1) effects of 8‐OH‐DPAT. 5 The evidence obtained for mediation of the hypothermic response to 5‐HT1A agonists by postsynaptic sites is relevant to the interpretation of the effects on it of antidepressant treatments and depressive illness.
British Journal of Pharmacology – Wiley
Published: Jul 1, 1992
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.