Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Bar, G. Saldanha, A. Kennedy, P. Facer, Rolfe Birch, T. Carlstedt, Praveen Anand (1998)
GDNF and its receptor component Ret in injured human nerves and dorsal root gangliaNeuroReport, 9
P. Naveilhan, W. ElShamy, P. Ernfors (1997)
Differential Regulation of mRNAs for GDNF and its Receptors Ret and GDNFRα After Sciatic Nerve Lesion in the MouseEuropean Journal of Neuroscience, 9
S. Pshenichkin, Anna Szekely, B. Wise (1994)
Transcriptional and Posttranscriptional Mechanisms Involved in the Interleukin‐1, Steroid, and Protein Kinase C Regulation of Nerve Growth Factor in Cortical AstrocytesJournal of Neurochemistry, 63
Tan (1994)
Fibroblast growth factor and cyclic AMP (AMP) synergistically activate gene expression at a cAMP response elementMol Cell Biol, 14
L.-F. Lin, D. Doherty, J. Lile, S. Bektesh, F. Collins (1993)
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.Science, 260 5111
Bishop (1995)
Effects of elevated ntracellular calcium on GDNF expressionSoc Neurosci Abstr, 21
D. Gash, Zhiming Zhang, Aliza Ovadia, W. Cass, Ai Yi, L. Simmerman, D. Russell, David Martin, P. Lapchak, F. Collins, B. Hoffer, Greg Gerhard (1996)
Functional recovery in parkinsonian monkeys treated with GDNFNature, 380
Cecilia Kearns, D. Gash (1995)
GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivoBrain Research, 672
D. Lindholm, E. Castrén, B. Hengerer, F. Zafra, B. Berninger, H. Thoenen (1992)
Differential Regulation of Nerve Growth Factor (NGF) Synthesis in Neurons and Astrocytes by Glucocorticoid HormonesEuropean Journal of Neuroscience, 4
Lin (1996)
Glial cell line-derived neurotrophic factor (GDNF): A comprehensive reviewNeural Notes, 11
C. Suter-Crazzolara, K. Unsicker (1996)
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.Brain research. Molecular brain research, 41 1-2
J. Springer, J. Seeburger, H. Jin, Ana Gabrea, E. Blankenhorn, L. Bergman (1995)
cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscleExperimental Neurology, 131
Yi Tan, J. Rouse, '. AihuaZhang, Sophia Cariatil, Philip Cohen, Michael Combl (1996)
FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.The EMBO Journal, 15
Brooks Jw, Mizel Sb (1994)
Interleukin-1 signal transduction.European Cytokine Network, 5
R. Kolesnick, D. Golde (1994)
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalingCell, 77
Dale Scharr, B. Sieber, C. Dreyfus, I. Black (1993)
Regional and Cell-Specific Expression of GDNF in Rat BrainExperimental Neurology, 124
J. Rogers, S. Webster, L. Lue, L. Brachova, W. Civin, M. Emmerling, B. Shivers, D. Walker, P. Mcgeer (1996)
Inflammation and Alzheimer's disease pathogenesisNeurobiology of Aging, 17
Y. Tan, K. Low, C. Boccia, J. Grossman, M. Comb (1994)
Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response elementMolecular and Cellular Biology, 14
X. Vigé, Binwu Tang, B. Wise (1992)
Cortical neurons inhibit basal and interleukin-1-stimulated astroglial cell secretion of nerve growth factorBrain Research, 591
Angela Ho, A. Gore, C. Weickert, Mariann Blum (1995)
Glutamate regulation of GDNF gene expression in the striatum and primary striatal astrocytes.Neuroreport, 6 10
G. Liberatore, J. Wong, M. Porritt, G. Donnan, D. Howells (1997)
Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum.Neuroreport, 8 14
H. Sauer, C. Rosenblad, A. Björklund (1995)
Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion.Proceedings of the National Academy of Sciences of the United States of America, 92 19
J. Pichel, Liya Shen, H. Sheng, A. Granholm, J. Drago, A. Grinberg, Eric Lee, S. Huang, M. Saarma, B. Hoffer, H. Sariola, H. Westphal (1996)
Defects in enteric innervation and kidney development in mice lacking GDNFNature, 382
Howard Mount, Deyrick Dean, Jordi Alberch, C. Dreyfus, Ira Black (1995)
Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells.Proceedings of the National Academy of Sciences of the United States of America, 92 20
J. Scully, U. Otten (1995)
Neurotrophin expression modulated by glucocorticoids and oestrogen in immortalized hippocampal neurons.Brain research. Molecular brain research, 31 1-2
R. Heller, M. Krönke (1994)
Tumor necrosis factor receptor-mediated signaling pathwaysThe Journal of Cell Biology, 126
K. Beck, J. Valverde, T. Alexi, K. Poulsen, B. Moffat, R. Vandlen, A. Rosenthal, F. Hefti (1995)
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brainNature, 373
C. Suter-Crazzolara, K. Unsicker (1994)
GDNF is expressed in two forms in many tissues outside the CNS.Neuroreport, 5 18
Fan Zhang, S. Endo, L. Cleary, A. Eskin, J. Byrne (1997)
Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in AplysiaScience, 275
E. Appel, O. Kolman, G. Kazimirsky, P. Blumberg, C. Brodie (1997)
Regulation of GDNF expression in cultured astrocytes by inflammatory stimuliNeuroReport, 8
D. Choi-Lundberg, Q. Lin, Yung-Nien Chang, Y. Chiang, Carl Hay, H. Mohajeri, B. Davidson, M. Bohn (1997)
Dopaminergic Neurons Protected from Degeneration by GDNF Gene TherapyScience, 275
P. Naveilhan, I. Neveu, D. Wion, P. Brachet (1996)
1,25‐Dihydroxyvitamin D3, an inducer of glial cell line‐derived neurotrophic factorNeuroReport, 7
T. Janet, G. Lüdecke, U. Otten, K. Unsicker (1995)
Heterogeneity of human neuroblastoma cell lines in their proliferative responses to basic FGF, NGF, and EGF: Correlation with expression of growth factors and growth factor receptorsJournal of Neuroscience Research, 40
C. Henderson, H. Phillips, R. Pollock, A. Davies, C. Lemeulle, M. Armanini, L. Simmons, B. Moffet, R. Vandlen, L. Simmons, V. Koliatsos, A. Rosenthal (1994)
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.Science, 266 5187
C. Nosrat, A. Tomac, E. Lindqvist, S. Lindskog, C. Humpel, I. Strömberg, T. Ebendal, B. Hoffer, L. Olson (1996)
Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous systemCell and Tissue Research, 286
Coleman (1994)
Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypesPharmacol Rev, 46
Miles Trupp, E. Arenas, M. Fainzilber, A. Nilsson, B. Sieber, M. Grigoriou, C. Kilkenny, E. Salazar-Grueso, V. Pachnis, U. Arumäe, H. Sariola, M. Saarma, C. Ibáñez (1996)
Functional receptor for GDNF encoded by the c-ret proto-oncogeneNature, 381
J. Treanor, L. Goodman, F. Sauvage, D. Stone, K. Poulsen, C. Beck, C. Gray, M. Armanini, R. Pollock, F. Hefti, H. Phillips, A. Goddard, M. Moore, A. Buj‐Bello, A. Davies, N. Asai, Masahide Takahashi, R. Vandlen, C. Henderson, A. Rosenthal (1996)
Characterization of a multicomponent receptor for GDNFNature, 382
G. Guy, S. Chua, N. Wong, S. Ng, Y. Tan (1991)
Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts.The Journal of biological chemistry, 266 22
I. Neveu, N. Barbot, F. Jehan, D. Wion, P. Brachet (1991)
Antagonistic effects of dexamethasone and 1,25-dihydroxyvitamin D3 on the synthesis of nerve growth factorMolecular and Cellular Endocrinology, 78
M. Lindner, S. Winn, E. Baetge, J. Hammang, F. Gentile, E. Doherty, P. Mcdermott, B. Frydel, M. Ullman, T. Schallert, D. Emerich (1995)
Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptomsExperimental Neurology, 132
N. Pochon, A. Menoud, J. Tseng, A. Zurn, Patrick Aebischer (1997)
Neuronal GDNF Expression in the Adult Rat Nervous System Identified By In Situ HybridizationEuropean Journal of Neuroscience, 9
I. Strömberg, L. Björklund, M. Johansson, A. Tomac, F. Collins, L. Olson, B. Hoffer, C. Humpel (1993)
Glial Cell Line-Derived Neurotrophic Factor Is Expressed in the Developing but Not Adult Striatum and Stimulates Developing Dopamine Neurons in VivoExperimental Neurology, 124
A. Verity, T. Wyatt, B. Hajos, R. Eglen, P. Baecker, Randolph Johnson (1998)
Regulation of Glial Cell Line‐Derived Neurotrophic Factor Release from Rat C6 Glioblastoma CellsJournal of Neurochemistry, 70
Dirk Schindelhauer, Simone Schuffenhauer, T. Gasser, A. Steinkasserer, T. Meitinger (1995)
The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1.Genomics, 28 3
E. Davis, D. Morris (1991)
Medicinal uses of licorice through the millennia: The good and plenty of itMolecular and Cellular Endocrinology, 78
P. Durbec, Lena Larsson-Blomberg, A. Schuchardt, F. Costantini, V. Pachnis (1996)
Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.Development, 122 1
Andreas Blochl, H. Thoenen (1995)
Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated PathwayEuropean Journal of Neuroscience, 7
K. Pierce, D. Gil, D. Woodward, J. Regan (1995)
Cloning of human prostanoid receptors.Trends in pharmacological sciences, 16 8
D. Woodbury, D. Schaar, Lakshmi Ramakrishnan, I. Black (1998)
Novel structure of the human GDNF geneBrain Research, 803
R. Rush, R. Mayo, C. Zettler (1995)
The regulation of nerve growth factor synthesis and delivery to peripheral neurons.Pharmacology & therapeutics, 65 1
Moller (1997)
Localization of epitope-tagged nerve growth factor and neurotrophin-3 to dense core granules in neuroendocrine cellsSoc Neurosci Abs, 23
P. Durbec, C. Marcos-Gutierrez, C. Kilkenny, M. Grigoriou, Kirmo Wartiowaara, P. Suvanto, Darrin Smith, B. Ponder, F. Costantini, M. Saarma, H. Sariola, V. Pachnis (1996)
GDNF signalling through the Ret receptor tyrosine kinaseNature, 381
Leu‐Fen Lin, T. Zhang, F. Collins, L. Armes (1994)
Purification and Initial Characterization of Rat B49 Glial Cell Line‐Derived Neurotrophic FactorJournal of Neurochemistry, 63
D. Molliver, D. Wright, M. Leitner, A. Parsadanian, K. Doster, D. Wen, Q. Yan, W. Snider (1997)
IB4-Binding DRG Neurons Switch from NGF to GDNF Dependence in Early Postnatal LifeNeuron, 19
Vige (1991)
Mechansim of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytesMol Pharm, 40
K. Bowenkamp, A. Hoffman, G. Gerhardt, M. Henry, P. Biddle, B. Hoffer, A. Granholm (1995)
Glial cell line‐derived neurotrophic factor supports survival of injured midbrain dopaminergic neuronsJournal of Comparative Neurology, 355
N. Lehming, D. Thanos, J. Brickman, Jun Ma, T. Maniatis, M. Ptashne (1994)
An HMG-like protein that can switch a transcriptional activator to a repressorNature, 371
R. Coleman, W. Smith, S. Narumiya (1994)
VIII. International union of pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypesPharmacological Reviews, 46
Christian Humpel, Barry Hoffer, Ingrid Strömberg, S. Bektesh, Frank Collins, Lars Olson (1994)
Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger rna in response to kainate-induced excitationNeuroscience, 59
Marina Sánchez, I. Silos-santiago, J. Frisén, Bin He, S. Lira, M. Barbacid (1996)
Renal agenesis and the absence of enteric neurons in mice lacking GDNFNature, 382
Miles Trupp, M. Rydén, H. Jörnvall, H. Funakoshi, T. Timmusk, E. Arenas, C. Ibáñez (1995)
Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neuronsThe Journal of Cell Biology, 130
Shoei Furukawa, Y. Furukawa, E. Satoyoshi, Kyozo Hayashi (1987)
Synthesis/secretion of nerve growth factor is associated with cell growth in cultured mouse astroglial cells.Biochemical and biophysical research communications, 142 2
M. Moore, R. Klein, I. Fariñas, H. Sauer, M. Armanini, H. Phillips, L. Reichardt, A. Ryan, K. Carver-Moore, A. Rosenthal (1996)
Renal and neuronal abnormalities in mice lacking GDNFNature, 382
A. Zurn, E. Baetge, J. Hammang, S. Tan, Patrick Aebischer (1994)
Glial cell line‐derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneuronesNeuroReport, 6
D. Choi-Lundberg, Martha Bohn (1995)
Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat.Brain research. Developmental brain research, 85 1
H. Thoenen (1995)
Neurotrophins and Neuronal PlasticityScience, 270
B. Lu, M. Yokoyama, C. Dreyfus, I. Black (1991)
NGF gene expression in actively growing brain glia, 11
J. Heymach, A. Krüttgen, U. Suter, E. Shooter (1996)
The Regulated Secretion and Vectorial Targeting of Neurotrophins in Neuroendocrine and Epithelial Cells*The Journal of Biological Chemistry, 271
A. Buj‐Bello, V. Buchman, A. Horton, A. Rosenthal, A. Davies (1995)
GDNF is an age-specific survival factor for sensory and autonomic neuronsNeuron, 15
D. Schaar, B. Sieber, A. Sherwood, D. Dean, Grace Mendoza, Lakshmi Ramakrishnan, C. Dreyfus, I. Black (1994)
Multiple Astrocyte Transcripts Encode Nigral Trophic Factors in Rat and HumanExperimental Neurology, 130
A. Tomac, E. Lindqvist, L.-F. Lin, S. Ögren, D. Young, B. Hoffer, L. Olson (1995)
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivoNature, 373
D. Lindholm, R. Heumann, B. Hengerer, H. Thoenen (1988)
Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.The Journal of biological chemistry, 263 31
Henheik (1997)
Co-release of GDNF and TGF-β accounts for the neurotrophic activity of chromaffin granule proteinSoc Neurosci Abs, 23
R. Schmidt-Kastner, A. Tomac, B. Hoffer, S. Bektesh, B. Rosenzweig, L. Olson (1994)
Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats.Brain research. Molecular brain research, 26 1-2
A. Schuchardt, V. D’Agati, Lena Larsson-Blomberg, F. Costantini, V. Pachnis (1994)
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor RetNature, 367
Human SK‐N‐AS neuroblastoma and U‐87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line–derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines differentially regulated GDNF release. A 24‐hr exposure to tumor necrosis factor‐α (TNFα; 10 ng/ml) or interleukin‐1β (IL‐1β; 10 ng/ml) induced GDNF release in U‐87MG cells, but repressed GDNF release from SK‐N‐AS cells. Fibroblast growth factors (FGF)‐1, ‐2, and ‐9 (50 ng/ml), the prostaglandins PGA2, PGE2, and PGI2 (10 μM), phorbol 12,13‐didecanoate (PDD; 10 nM), okadaic acid (10 nM), dexamethasone (1 μM), and vitamin D3 (1 μm) also differentially effected GDNF release from U‐87MG and SK‐N‐AS cells. A result shared by both cell lines, was a two‐ to threefold increase in GDNF release by db‐cAMP (1 mM), or forskolin (10 μM). In general, analysis of steady‐state GDNF mRNA levels correlated with changes in extracellular GDNF levels in U‐87MG cells but remained static in SK‐N‐AS cells. The data suggest that human GDNF synthesis/release can be regulated by numerous facto, signaling through multiple and diverse secondary messenger systems. Furthermore, we provide evidence of differential regulation of human GDNF synthesis/release in cells of glial (U‐87MG) and neuronal (SK‐N‐AS) origin. J. Neurosci. Res. 55:187–197, 1999. © 1999 Wiley‐Liss, Inc.
Journal of Neuroscience Research – Wiley
Published: Jan 15, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.