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The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation The biological role of cyclic GMP in vascular smooth muscle regulation is a relatively new concept that had its debut at a time when the biological signifi­ cance of alterations in cellular levels of cyclic GMP was itself a controversial issue. Indeed, even today the physiological importance of this cyclic nucleotide remains unclear, although recent studies may be on the verge of providing important new insights. Information on the regulatory role of cyclic AMP, on the other hand, is far more prevalent, probably because such studies com­ menced about fifteen years prior to those on cyclic GMP, and many more investigators are presently studying cyclic AMP than are studying cyclic GMP. Progress in cyclic GMP research seems to have been thwarted somewhat because certain concepts developed in the mid-1970s no longer appear to be tenable. Due in part to the paucity of basic information on cyclic GMP at the time, incompletely tested hypotheses were forwarded that suggested that cyclic GMP might be involved in the contraction of smooth muscle, including vascular smooth muscle. This was an attractive hypothesis because other studies had suggested that cyclic AMP was involved in smooth muscle relaxa­ tion, thereby providing the intriguing concept http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

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Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.25.040185.001131
pmid
2988418
Publisher site
See Article on Publisher Site

Abstract

The biological role of cyclic GMP in vascular smooth muscle regulation is a relatively new concept that had its debut at a time when the biological signifi­ cance of alterations in cellular levels of cyclic GMP was itself a controversial issue. Indeed, even today the physiological importance of this cyclic nucleotide remains unclear, although recent studies may be on the verge of providing important new insights. Information on the regulatory role of cyclic AMP, on the other hand, is far more prevalent, probably because such studies com­ menced about fifteen years prior to those on cyclic GMP, and many more investigators are presently studying cyclic AMP than are studying cyclic GMP. Progress in cyclic GMP research seems to have been thwarted somewhat because certain concepts developed in the mid-1970s no longer appear to be tenable. Due in part to the paucity of basic information on cyclic GMP at the time, incompletely tested hypotheses were forwarded that suggested that cyclic GMP might be involved in the contraction of smooth muscle, including vascular smooth muscle. This was an attractive hypothesis because other studies had suggested that cyclic AMP was involved in smooth muscle relaxa­ tion, thereby providing the intriguing concept

Journal

Annual Review of Pharmacology and ToxicologyAnnual Reviews

Published: Apr 1, 1985

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