Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Shioji, Hajime Nakamura, H. Masutani, J. Yodoi (2003)
Redox regulation by thioredoxin in cardiovascular diseases.Antioxidants & redox signaling, 5 6
G. Warren, L. O'farrell, M. Summan, T. Hulderman, D. Mishra, M. Luster, W. Kuziel, P. Simeonova (2004)
Role of CC chemokines in skeletal muscle functional restoration after injury.American journal of physiology. Cell physiology, 286 5
P. Ralph, M. Ho, P. Litcofsky, T. Springer (1983)
Expression and induction in vitro of macrophage differentiation antigens on murine cell lines.Journal of immunology, 130 1
M. Pfaffl (2001)
A new mathematical model for relative quantification in real-time RT-PCR.Nucleic acids research, 29 9
J. Tidball, Eugene Berchenko, J. Frenette (1999)
Macrophage invasion does not contribute to muscle membrane injury during inflammationJournal of Leukocyte Biology, 65
Nadine Winn, Angelika Paul, A. Musarò, Nadia Rosenthal (2002)
Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease.Cold Spring Harbor symposia on quantitative biology, 67
(1994)
Structure, ligand-binding mechanism and signal transduction
J. Tidball (1995)
Inflammatory cell response to acute muscle injury.Medicine and science in sports and exercise, 27 7
Q. Qian, M. Jutila, N. Rooijen, Jim Cutler (1994)
Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis.Journal of immunology, 152 10
B. Pierre, J. Tidball (1994)
Macrophage activation and muscle remodeling at myotendinous junctions after modifications in muscle loading.The American journal of pathology, 145 6
C. Sunderkötter, T. Nikolić, M. Dillon, N. Rooijen, M. Stehling, D. Drevets, P. Leenen (2004)
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response1The Journal of Immunology, 172
L. Almekinders (1993)
Anti-Inflammatory Treatment of Muscular Injuries in SportSports Medicine, 28
M. Cantini, U. Carraro (1995)
Macrophage‐released Factor Stimulates Selectively Myogenic Cells in Primary Muscle CultureJournal of Neuropathology and Experimental Neurology, 54
K. Cooper, N. Duraiswamy, C. Hammerberg, E. Allen, C. Kimbrough-Green, W. Dillon, D. Thomas (1993)
Neutrophils, differentiated macrophages, and monocyte/macrophage antigen presenting cells infiltrate murine epidermis after UV injury.The Journal of investigative dermatology, 101 2
S. Orimo, E. Hiyamuta, K. Arahata, H. Sugita (1991)
Analysis of inflammatory cells and complement C3 in bupivacaine‐induced myonecrosisMuscle & Nerve, 14
M. Summan, M. McKinstry, G. Warren, T. Hulderman, D. Mishra, K. Brumbaugh, M. Luster, P. Simeonova (2003)
Inflammatory mediators and skeletal muscle injury: a DNA microarray analysis.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 23 5
Gordon Warren, T. Hulderman, N. Jensen, M. McKinstry, Michael Mishra, M. Luster, P. Simeonova (2002)
Physiological role of tumor necrosis factor α in traumatic muscle injuryThe FASEB Journal, 16
P. Popovich, Z. Guan, P. Wei, I. Huitinga, N. Rooijen, B. Stokes (1999)
Depletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord InjuryExperimental Neurology, 158
J. Fowlkes, K. Thrailkill, C. George-Nascimento, C. Rosenberg, D. Serra (1997)
Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation.Endocrinology, 138 6
N. Rooijen, A. Sanders (1997)
Elimination, blocking, and activation of macrophages: three of a kind?Journal of leukocyte biology, 62 6
L. Piali, P. Hammel, C. Uherek, F. Bachmann, R. Gisler, D. Dunon, B. Imhof, Cnrs Ura (1995)
CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endotheliumThe Journal of Cell Biology, 130
M. Wehling, M. Spencer, J. Tidball (2001)
A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx miceThe Journal of Cell Biology, 155
J. Tidball (2005)
Inflammatory processes in muscle injury and repair.American journal of physiology. Regulatory, integrative and comparative physiology, 288 2
N. Rooijen, A. Sanders (1994)
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.Journal of immunological methods, 174 1-2
Gordon Warren, T. Hulderman, D. Mishra, Xin Gao, L. Millecchia, L. O'farrell, W. Kuziel, P. Simeonova (2005)
Chemokine receptor CCR2 involvement in skeletal muscle regenerationThe FASEB Journal, 19
L. Lescaudron, E. Peltékian, J. Fontaine-Pérus, D. Paulin, M. Zampieri, L. Garcia, E. Parrish (1999)
Blood borne macrophages are essential for the triggering of muscle regeneration following muscle transplantNeuromuscular Disorders, 9
L. DiPietro (1995)
WOUND HEALING: THE ROLE OF THE MACROPHAGE AND OTHER IMMUNE CELLSShock, 4
I. McLennan (1993)
Resident macrophages (ED2- and ED3-positive) do not phagocytose degenerating rat skeletal muscle fibresCell and Tissue Research, 272
D. Sheehan, B. Hrapchak (1980)
Theory and Practice of Histotechnology
C. Mitchell, J. McGeachie, M. Grounds (1992)
Cellular differences in the regeneration of murine skeletal muscle: a quantitative histological study in SJL/J and BALB/c miceCell and Tissue Research, 269
Brenda Bondesen, S. Mills, K. Kegley, G. Pavlath (2004)
The COX-2 pathway is essential during early stages of skeletal muscle regeneration.American journal of physiology. Cell physiology, 287 2
P. Meyts, B. Wallach, C. Christoffersen, B. Ursø, K. Grønskov, L. Latus, Fumiatsu Yakushiji, M. Ilondo, R. Shymko (1994)
The Insulin-Like Growth Factor-I ReceptorHormone Research, 42
Timo Hurme, H. Kalimo (1992)
Activation of myogenic precursor cells after muscle injury.Medicine and science in sports and exercise, 24 2
C. Mendias, R. Tatsumi, R. Allen (2004)
Role of cyclooxygenase‐1 and ‐2 in satellite cell proliferation, differentiation, and fusionMuscle & Nerve, 30
V. Prisk, J. Huard (2003)
Muscle injuries and repair: the role of prostaglandins and inflammation.Histology and histopathology, 18 4
L. Sabourin, M. Rudnicki (2000)
The molecular regulation of myogenesisClinical Genetics, 57
A. Buzdin, S. Ustyugova, K. Khodosevich, I. Mamedov, Y. Lebedev, G. Hunsmann, E. Sverdlov (2003)
Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages.Genomics, 81 2
D. Lowe, Gordon Warren, C. Ingalls, D. Boorstein, R. Armstrong (1995)
Muscle function and protein metabolism after initiation of eccentric contraction-induced injury.Journal of applied physiology, 79 4
C. Daly, B. Rollins (2003)
Monocyte Chemoattractant Protein‐1 (CCL2) in Inflammatory Disease and Adaptive Immunity: Therapeutic Opportunities and ControversiesMicrocirculation, 10
F. Pixley, E. Stanley (2004)
CSF-1 regulation of the wandering macrophage: complexity in action.Trends in cell biology, 14 11
T. Robertson, M. Maley, M. Grounds, J. Papadimitriou (1993)
The role of macrophages in skeletal muscle regeneration with particular reference to chemotaxis.Experimental cell research, 207 2
M. Massimino, E. Rapizzi, M. Cantini, L. Libera, Francesco Mazzoleni, Paola Arslan, Ugo Carraro (1997)
ED2+ macrophages increase selectively myoblast proliferation in muscle cultures.Biochemical and biophysical research communications, 235 3
F. Cerignoli, C. Ambrosi, M. Mellone, I. Assimi, L. Marcotullio, A. Gulino, G. Giannini (2004)
HMGA Molecules in Neuroblastic TumorsAnnals of the New York Academy of Sciences, 1028
S. Welle, A. Brooks, J. Delehanty, Nancy Needler, C. Thornton (2003)
Gene expression profile of aging in human muscle.Physiological genomics, 14 2
The study evaluates the influence of monocytes/macrophages in the mechanisms of skeletal muscle injury using a mouse model and selective depletion of peripheral monocyte with systemic injections of liposomal clodronate (dichloromethylene bisphosphonate). This pharmacological treatment has been demonstrated to induce specific apoptotic death in monocytes and phagocytic macrophages. In the current studies, the liposomal clodronate injections resulted in a marked attenuation of the peak inflammatory response in the freeze-injured muscle in the first three days after injury. The effect was accompanied by a transient reduction (at day 1 or 3 postinjury) of the expression of several genes coding for inflammatory, as well as growth-related mediators, including TNF, monocyte chemoattractant protein (MCP)-1, thioredoxin, high-mobility group AT-hook 1, insulin-like growth factor-binding protein (IGFBP), and IGF-1. In contrast, the expression of major myogenic factors (i.e., MyoD and myogenin) directly involved in the activation/proliferation and differentiation of muscle precursor cells was not altered by the clodronate liposome treatment. The repair process in the injured muscle of clodronate liposome-treated mice was characterized by prolonged clearance of necrotic myofibers and a tendency for increased muscle fat accumulation at day 9 and 14 postinjury, respectively. In conclusion, a significant reduction of the initial monocyte/macrophage influx into the injured muscle is associated with not improved, but moderately impaired, repair processes after skeletal muscle injury. skeletal muscle injury; inflammation; myogenesis; gene expression Address for reprint requests and other correspondence: P. Simeonova, Health Effects Laboratory Div., National Institute for Occupational Safety and Health, Morgantown, WV 26505 (e-mail: PSimeonova@cdc.gov )
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Jun 1, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.