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Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation

Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and... International Journal of Obesity (2013) 37, 1386–1390 & 2013 Macmillan Publishers Limited All rights reserved 0307-0565/13 www.nature.com/ijo ORIGINAL ARTICLE Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation 1,2 1,2 1 1 1 2 M Straczkowski , M Karczewska-Kupczewska , A Adamska , E Otziomek , I Kowalska and A Niko"ajuk OBJECTIVE: Fibroblast growth factor 21 (FGF21) reduces plasma glucose and triglycerides, and increases free fatty acid oxidation in animal models of diabetes. The aim of the present study was to assess the relationships of serum FGF21 with glucose oxidation (GOx) and lipid oxidation (LOx) in the baseline and insulin-stimulated conditions in lean and obese subjects. DESIGN: Cross-sectional study. SUBJECTS: Eighty-four subjects with normal glucose tolerance, 42 lean (body mass index (BMI) o25 kg m ) and 42 overweight or obese (BMI between 25 and 40 kg m ). MEASUREMENTS: Euglycemic hyperinsulinemic clamp and indirect calorimetry in the baseline state and during last 30 min of the clamp. The change in respiratory quotient (DRQ) in response to insulin was used as a measure of metabolic flexibility. Serum FGF21 was determined in the baseline state and after the clamp. RESULTS: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Obesity Springer Journals

Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation

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References (109)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Macmillan Publishers Limited
Subject
Medicine & Public Health; Medicine/Public Health, general; Public Health; Epidemiology; Internal Medicine; Metabolic Diseases; Health Promotion and Disease Prevention
ISSN
0307-0565
eISSN
1476-5497
DOI
10.1038/ijo.2013.10
Publisher site
See Article on Publisher Site

Abstract

International Journal of Obesity (2013) 37, 1386–1390 & 2013 Macmillan Publishers Limited All rights reserved 0307-0565/13 www.nature.com/ijo ORIGINAL ARTICLE Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation 1,2 1,2 1 1 1 2 M Straczkowski , M Karczewska-Kupczewska , A Adamska , E Otziomek , I Kowalska and A Niko"ajuk OBJECTIVE: Fibroblast growth factor 21 (FGF21) reduces plasma glucose and triglycerides, and increases free fatty acid oxidation in animal models of diabetes. The aim of the present study was to assess the relationships of serum FGF21 with glucose oxidation (GOx) and lipid oxidation (LOx) in the baseline and insulin-stimulated conditions in lean and obese subjects. DESIGN: Cross-sectional study. SUBJECTS: Eighty-four subjects with normal glucose tolerance, 42 lean (body mass index (BMI) o25 kg m ) and 42 overweight or obese (BMI between 25 and 40 kg m ). MEASUREMENTS: Euglycemic hyperinsulinemic clamp and indirect calorimetry in the baseline state and during last 30 min of the clamp. The change in respiratory quotient (DRQ) in response to insulin was used as a measure of metabolic flexibility. Serum FGF21 was determined in the baseline state and after the clamp. RESULTS:

Journal

International Journal of Obesity – Springer Journals

Published: Feb 19, 2013

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